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Urinary excretion of black raspberry (Rubus occidentalis) anthocyanins and their metabolites.
J Agric Food Chem. 2006 Feb 22; 54(4):1467-72.JA

Abstract

Anthocyanins are the most abundant phenolic compounds, widely distributed in fruits and vegetables, and exhibit potent antioxidant capacity. Humans ingest a significant amount of anthocyanins in the daily diet. The objective of the current study was to examine human absorption and metabolism of black raspberry anthocyanins when administered at high doses (2.69 +/- 0.085 g/day). Ten healthy men consumed 45 g of freeze-dried black raspberries daily for 1 week. Urine samples were collected over a 12 h period in 4 h intervals at day 1 and day 7. Urinary anthocyanins were analyzed by high-performance liquid chromatography coupled to a photodiode array detector and a tandem mass spectrometer using precursor ion and product ion analyses. Anthocyanins were excreted in intact forms and metabolized into methylated derivatives in human urine. The urinary excretion of anthocyanins reached a maximum concentration (1091.8 +/- 1081.3 pmol/L, n = 10) during the 4-8 h period after black raspberry ingestion. As compared to the anthocyanin distribution in black raspberries, urinary cyanidin 3-xylosylrutinoside was detected at a higher concentration than that of cyanidin-3-rutinoside.

Authors+Show Affiliations

Tian Q
Department of Food Science and Technology, The Ohio State University, 2015 Fyffe Road, Columbus, Ohio 43210, USA.
Giusti MM
No affiliation info available
Stoner GD
No affiliation info available
Schwartz SJ
No affiliation info available

MeSH

AbsorptionAdultAnthocyaninsChromatography, High Pressure LiquidFruitHumansMaleMass SpectrometryRosaceae

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16478275

Citation

Tian, Qingguo, et al. "Urinary Excretion of Black Raspberry (Rubus Occidentalis) Anthocyanins and Their Metabolites." Journal of Agricultural and Food Chemistry, vol. 54, no. 4, 2006, pp. 1467-72.
Tian Q, Giusti MM, Stoner GD, et al. Urinary excretion of black raspberry (Rubus occidentalis) anthocyanins and their metabolites. J Agric Food Chem. 2006;54(4):1467-72.
Tian, Q., Giusti, M. M., Stoner, G. D., & Schwartz, S. J. (2006). Urinary excretion of black raspberry (Rubus occidentalis) anthocyanins and their metabolites. Journal of Agricultural and Food Chemistry, 54(4), 1467-72.
Tian Q, et al. Urinary Excretion of Black Raspberry (Rubus Occidentalis) Anthocyanins and Their Metabolites. J Agric Food Chem. 2006 Feb 22;54(4):1467-72. PubMed PMID: 16478275.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Urinary excretion of black raspberry (Rubus occidentalis) anthocyanins and their metabolites. AU - Tian,Qingguo, AU - Giusti,M Monica, AU - Stoner,Gary D, AU - Schwartz,Steven J, PY - 2006/2/16/pubmed PY - 2006/4/7/medline PY - 2006/2/16/entrez SP - 1467 EP - 72 JF - Journal of agricultural and food chemistry JO - J Agric Food Chem VL - 54 IS - 4 N2 - Anthocyanins are the most abundant phenolic compounds, widely distributed in fruits and vegetables, and exhibit potent antioxidant capacity. Humans ingest a significant amount of anthocyanins in the daily diet. The objective of the current study was to examine human absorption and metabolism of black raspberry anthocyanins when administered at high doses (2.69 +/- 0.085 g/day). Ten healthy men consumed 45 g of freeze-dried black raspberries daily for 1 week. Urine samples were collected over a 12 h period in 4 h intervals at day 1 and day 7. Urinary anthocyanins were analyzed by high-performance liquid chromatography coupled to a photodiode array detector and a tandem mass spectrometer using precursor ion and product ion analyses. Anthocyanins were excreted in intact forms and metabolized into methylated derivatives in human urine. The urinary excretion of anthocyanins reached a maximum concentration (1091.8 +/- 1081.3 pmol/L, n = 10) during the 4-8 h period after black raspberry ingestion. As compared to the anthocyanin distribution in black raspberries, urinary cyanidin 3-xylosylrutinoside was detected at a higher concentration than that of cyanidin-3-rutinoside. SN - 0021-8561 UR - https://www.unboundmedicine.com/medline/citation/16478275/Urinary_excretion_of_black_raspberry__Rubus_occidentalis__anthocyanins_and_their_metabolites_ DB - PRIME DP - Unbound Medicine ER -