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Transcranial magnetic stimulation screening for cord compression in cervical spondylosis.
J Neurol Sci. 2006 May 15; 244(1-2):17-21.JN

Abstract

OBJECTIVE

Cervical spondylosis (CS) often results in various degrees of cord compression, which can be evaluated functionally with transcranial magnetic stimulation (TMS). We investigate the use of TMS as a screening tool for myelopathy in CS.

METHODS

We prospectively studied 231 patients classified into Groups 1 to 4 based on MRI grading of severity of cord compromise. TMS elicited central motor conduction times and motor evoked potential (MEP) amplitudes in all 4 limbs. The results were compared with those from 45 healthy controls.

RESULTS

TMS showed 98% sensitivity and 98% specificity for cord abnormality using MRI as reference standard.

CONCLUSIONS

MEP abnormalities are useful for electrophysiological evaluation of cord compression in CS. While TMS is not a substitute for MRI, it is of value as a rapid, inexpensive and non-invasive technique for screening patients before MRI studies.

Authors+Show Affiliations

Lo YL
Department of Neurology, National Neuroscience Institute, Singapore General Hospital, Singapore 169608, Singapore. gnrlyl@sgh.com.sg
Chan LL
No affiliation info available
Lim W
No affiliation info available
Tan SB
No affiliation info available
Tan CT
No affiliation info available
Chen JL
No affiliation info available
Fook-Chong S
No affiliation info available
Ratnagopal P
No affiliation info available

MeSH

AdultAgedCervical VertebraeElectromyographyEvoked Potentials, MotorFemaleHumansMaleMass ScreeningMiddle AgedNeural ConductionPredictive Value of TestsProspective StudiesPyramidal TractsRadiculopathySpinal CordSpinal Cord CompressionSpinal OsteophytosisTranscranial Magnetic Stimulation

Pub Type(s)

Controlled Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16478626

Citation

Lo, Y L., et al. "Transcranial Magnetic Stimulation Screening for Cord Compression in Cervical Spondylosis." Journal of the Neurological Sciences, vol. 244, no. 1-2, 2006, pp. 17-21.
Lo YL, Chan LL, Lim W, et al. Transcranial magnetic stimulation screening for cord compression in cervical spondylosis. J Neurol Sci. 2006;244(1-2):17-21.
Lo, Y. L., Chan, L. L., Lim, W., Tan, S. B., Tan, C. T., Chen, J. L., Fook-Chong, S., & Ratnagopal, P. (2006). Transcranial magnetic stimulation screening for cord compression in cervical spondylosis. Journal of the Neurological Sciences, 244(1-2), 17-21.
Lo YL, et al. Transcranial Magnetic Stimulation Screening for Cord Compression in Cervical Spondylosis. J Neurol Sci. 2006 May 15;244(1-2):17-21. PubMed PMID: 16478626.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Transcranial magnetic stimulation screening for cord compression in cervical spondylosis. AU - Lo,Y L, AU - Chan,L L, AU - Lim,W, AU - Tan,S B, AU - Tan,C T, AU - Chen,J L T, AU - Fook-Chong,S, AU - Ratnagopal,P, Y1 - 2006/02/14/ PY - 2005/02/04/received PY - 2005/10/28/revised PY - 2005/12/12/accepted PY - 2006/2/16/pubmed PY - 2006/7/29/medline PY - 2006/2/16/entrez SP - 17 EP - 21 JF - Journal of the neurological sciences JO - J Neurol Sci VL - 244 IS - 1-2 N2 - OBJECTIVE: Cervical spondylosis (CS) often results in various degrees of cord compression, which can be evaluated functionally with transcranial magnetic stimulation (TMS). We investigate the use of TMS as a screening tool for myelopathy in CS. METHODS: We prospectively studied 231 patients classified into Groups 1 to 4 based on MRI grading of severity of cord compromise. TMS elicited central motor conduction times and motor evoked potential (MEP) amplitudes in all 4 limbs. The results were compared with those from 45 healthy controls. RESULTS: TMS showed 98% sensitivity and 98% specificity for cord abnormality using MRI as reference standard. CONCLUSIONS: MEP abnormalities are useful for electrophysiological evaluation of cord compression in CS. While TMS is not a substitute for MRI, it is of value as a rapid, inexpensive and non-invasive technique for screening patients before MRI studies. SN - 0022-510X UR - https://www.unboundmedicine.com/medline/citation/16478626/Transcranial_magnetic_stimulation_screening_for_cord_compression_in_cervical_spondylosis_ DB - PRIME DP - Unbound Medicine ER -