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Percentage fall in FVC at the provocative concentration of methacholine causing a 20% fall in FEV1 in symptomatic asthma and clinical remission during adolescence.
Chest. 2006 Feb; 129(2):272-7.Chest

Abstract

BACKGROUND

Many children with asthma go into long-term clinical remission at adolescence, but bronchial hyperresponsiveness (BHR) persists in approximately one half of these subjects. BHR is usually assessed by measuring the provocative concentration of methacholine causing a 20% fall in FEV1 (PC20). The percentage fall in FVC at the PC20 (deltaFVC) has been suggested to be a more useful index of disease severity in asthma than PC20.

STUDY OBJECTIVE

The aim of this study was to determine whether deltaFVC is higher in adolescents with symptomatic asthma than in those with clinical remission.

PATIENTS AND METHODS

Forty adolescents with symptomatic asthma and 80 adolescents with asthma remission underwent methacholine challenge testing. DeltaFVC and PC20 were measured on the methacholine dose-response curve.

RESULTS

The mean (95% confidence interval [CI]) deltaFVC (15.5% [95% CI, 14.1 to 16.9%]) in the symptomatic group (n = 40) was significantly higher (p = 0.017) than that (12.8% [95% CI, 11.5 to 14.1%]) in the BHR-positive (PC20 < 16 mg/mL) remission group (n = 44) or that (11.5% [95% CI, 10.2 to 12.8%]) of the BHR-negative remission group (n = 36), with no difference between the two latter groups (p = 0.581). No significant correlation was found between deltaFVC and PC20 in the symptomatic group (r = -0.156, p = 0.336) or in the whole remission group (r = -0.187, p = 0.097).

CONCLUSIONS

Adolescents with symptomatic asthma had a higher deltaFVC than those with clinical remission, irrespective of the presence of BHR in the latter group. This finding suggests that deltaFVC may serve as an adjunct marker for differentiating between asthma persistence and remission during adolescence.

Authors+Show Affiliations

Department of Pediatrics, Korea University Anam Hospital, Seoul, Korea.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16478841

Citation

Yoo, Young, et al. "Percentage Fall in FVC at the Provocative Concentration of Methacholine Causing a 20% Fall in FEV1 in Symptomatic Asthma and Clinical Remission During Adolescence." Chest, vol. 129, no. 2, 2006, pp. 272-7.
Yoo Y, Yu J, Kim DK, et al. Percentage fall in FVC at the provocative concentration of methacholine causing a 20% fall in FEV1 in symptomatic asthma and clinical remission during adolescence. Chest. 2006;129(2):272-7.
Yoo, Y., Yu, J., Kim, D. K., & Koh, Y. Y. (2006). Percentage fall in FVC at the provocative concentration of methacholine causing a 20% fall in FEV1 in symptomatic asthma and clinical remission during adolescence. Chest, 129(2), 272-7.
Yoo Y, et al. Percentage Fall in FVC at the Provocative Concentration of Methacholine Causing a 20% Fall in FEV1 in Symptomatic Asthma and Clinical Remission During Adolescence. Chest. 2006;129(2):272-7. PubMed PMID: 16478841.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Percentage fall in FVC at the provocative concentration of methacholine causing a 20% fall in FEV1 in symptomatic asthma and clinical remission during adolescence. AU - Yoo,Young, AU - Yu,Jinho, AU - Kim,Do Kyun, AU - Koh,Young Yull, PY - 2006/2/16/pubmed PY - 2006/3/23/medline PY - 2006/2/16/entrez SP - 272 EP - 7 JF - Chest JO - Chest VL - 129 IS - 2 N2 - BACKGROUND: Many children with asthma go into long-term clinical remission at adolescence, but bronchial hyperresponsiveness (BHR) persists in approximately one half of these subjects. BHR is usually assessed by measuring the provocative concentration of methacholine causing a 20% fall in FEV1 (PC20). The percentage fall in FVC at the PC20 (deltaFVC) has been suggested to be a more useful index of disease severity in asthma than PC20. STUDY OBJECTIVE: The aim of this study was to determine whether deltaFVC is higher in adolescents with symptomatic asthma than in those with clinical remission. PATIENTS AND METHODS: Forty adolescents with symptomatic asthma and 80 adolescents with asthma remission underwent methacholine challenge testing. DeltaFVC and PC20 were measured on the methacholine dose-response curve. RESULTS: The mean (95% confidence interval [CI]) deltaFVC (15.5% [95% CI, 14.1 to 16.9%]) in the symptomatic group (n = 40) was significantly higher (p = 0.017) than that (12.8% [95% CI, 11.5 to 14.1%]) in the BHR-positive (PC20 < 16 mg/mL) remission group (n = 44) or that (11.5% [95% CI, 10.2 to 12.8%]) of the BHR-negative remission group (n = 36), with no difference between the two latter groups (p = 0.581). No significant correlation was found between deltaFVC and PC20 in the symptomatic group (r = -0.156, p = 0.336) or in the whole remission group (r = -0.187, p = 0.097). CONCLUSIONS: Adolescents with symptomatic asthma had a higher deltaFVC than those with clinical remission, irrespective of the presence of BHR in the latter group. This finding suggests that deltaFVC may serve as an adjunct marker for differentiating between asthma persistence and remission during adolescence. SN - 0012-3692 UR - https://www.unboundmedicine.com/medline/citation/16478841/Percentage_fall_in_FVC_at_the_provocative_concentration_of_methacholine_causing_a_20_fall_in_FEV1_in_symptomatic_asthma_and_clinical_remission_during_adolescence_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0012-3692(15)38746-8 DB - PRIME DP - Unbound Medicine ER -