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Hydroxyurea induced perimalleolar ulcers.
J Korean Med Sci. 2006 Feb; 21(1):177-9.JK

Abstract

Hydroxyurea (HU) is an antineoplastic drug commonly used to treat chronic myeloproliferative disorders. Common dermatological side effects include hyperpigmentation, scaling, erythema, alopecia, desquamation of face and hands. Leg ulceration following HU therapy is less common and very few cases have been reported so far. Objective of this paper is to increase the awareness of hydroxyurea induced leg ulcers which will aid in the early diagnosis and appropriate treatment. The first case was a chronic myeloid leukemia (CML) patient on HU 1.5 g/day for 5 yr, who had bilateral painful perimalleolar ulcers for 6 months. The second case was a CML patient on HU 1.5 g/day for 3 yr who developed bilateral lateral malleolar ulcers. Third case was a polycythemia vera (PV) patient on HU 1 g/day for 5 yr who presented with painful medial malleolar ulcer of 2 months. The last case of our report was an elderly PV patient on HU 1.5 g/day for 2 yr and presented with lateral malleolar ulcer which persisted on reducing the dose of HU. In all the 4 cases the ulcers healed on stopping HU. Our report confirms the association of chronic hydroxyurea therapy and perimalleolar ulcers which respond promptly after discontinuation of the drug. The heightened awareness among the physicians will promote early diagnosis and prompt relief from the agonizing ulcers.

Authors+Show Affiliations

Department of Medicine, Kasturba Medical College, Manipal, India. kavithasaravu@yahoo.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

16479088

Citation

Saravu, Kavitha, et al. "Hydroxyurea Induced Perimalleolar Ulcers." Journal of Korean Medical Science, vol. 21, no. 1, 2006, pp. 177-9.
Saravu K, Velappan P, Lakshmi N, et al. Hydroxyurea induced perimalleolar ulcers. J Korean Med Sci. 2006;21(1):177-9.
Saravu, K., Velappan, P., Lakshmi, N., Shastry, B. A., & Thomas, J. (2006). Hydroxyurea induced perimalleolar ulcers. Journal of Korean Medical Science, 21(1), 177-9.
Saravu K, et al. Hydroxyurea Induced Perimalleolar Ulcers. J Korean Med Sci. 2006;21(1):177-9. PubMed PMID: 16479088.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hydroxyurea induced perimalleolar ulcers. AU - Saravu,Kavitha, AU - Velappan,Praveen, AU - Lakshmi,Naik, AU - Shastry,Barkur Ananthakrishna, AU - Thomas,Joseph, PY - 2006/2/16/pubmed PY - 2006/4/11/medline PY - 2006/2/16/entrez SP - 177 EP - 9 JF - Journal of Korean medical science JO - J Korean Med Sci VL - 21 IS - 1 N2 - Hydroxyurea (HU) is an antineoplastic drug commonly used to treat chronic myeloproliferative disorders. Common dermatological side effects include hyperpigmentation, scaling, erythema, alopecia, desquamation of face and hands. Leg ulceration following HU therapy is less common and very few cases have been reported so far. Objective of this paper is to increase the awareness of hydroxyurea induced leg ulcers which will aid in the early diagnosis and appropriate treatment. The first case was a chronic myeloid leukemia (CML) patient on HU 1.5 g/day for 5 yr, who had bilateral painful perimalleolar ulcers for 6 months. The second case was a CML patient on HU 1.5 g/day for 3 yr who developed bilateral lateral malleolar ulcers. Third case was a polycythemia vera (PV) patient on HU 1 g/day for 5 yr who presented with painful medial malleolar ulcer of 2 months. The last case of our report was an elderly PV patient on HU 1.5 g/day for 2 yr and presented with lateral malleolar ulcer which persisted on reducing the dose of HU. In all the 4 cases the ulcers healed on stopping HU. Our report confirms the association of chronic hydroxyurea therapy and perimalleolar ulcers which respond promptly after discontinuation of the drug. The heightened awareness among the physicians will promote early diagnosis and prompt relief from the agonizing ulcers. SN - 1011-8934 UR - https://www.unboundmedicine.com/medline/citation/16479088/Hydroxyurea_induced_perimalleolar_ulcers_ DB - PRIME DP - Unbound Medicine ER -