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Two-year prospective study of the humoral immune response of patients with severe acute respiratory syndrome.
J Infect Dis. 2006 Mar 15; 193(6):792-5.JI

Abstract

In a cohort study of 56 convalescent patients with severe acute respiratory syndrome (SARS), titers of immunoglobulin G (IgG) antibodies and neutralizing antibodies (NAbs) against SARS-associated coronavirus were assessed at regular intervals (at 1, 4, 7, 10, 16, and 24 months after the onset of disease) by use of enzyme-linked immunosorbent assay and neutralization assay. IgG antibody and NAb titers were highly correlated, peaking at month 4 after the onset of disease and decreasing thereafter. IgG antibodies remained detectable in all patients until month 16, and they became undetectable in 11.8% of patients at month 24. The finding that NAbs remained detectable throughout follow-up is reassuring in terms of protection provided against reinfection; however, NAb titers decreased markedly after month 16.

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Authors+Show Affiliations

Liu W
Beijing Institute of Microbiology and Epidemiology, State Key Laboratory of Pathogen and Biosecurity, Beijing, People's Republic of China.
Fontanet A
No affiliation info available
Zhang PH
No affiliation info available
Zhan L
No affiliation info available
Xin ZT
No affiliation info available
Baril L
No affiliation info available
Tang F
No affiliation info available
Lv H
No affiliation info available
Cao WC
No affiliation info available

MeSH

Antibodies, ViralAntibody FormationCohort StudiesHumansImmunoglobulin GNeutralization TestsProspective StudiesSevere acute respiratory syndrome-related coronavirusSevere Acute Respiratory Syndrome

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16479513

Clinical Trial Links

Immune Responses to COVID-19; Isolation of Neutralizing Antibodies for Therapeutics and Vaccine.
Professional's Health in Epidemiological Crisis Covid-19

Citation

Liu, Wei, et al. "Two-year Prospective Study of the Humoral Immune Response of Patients With Severe Acute Respiratory Syndrome." The Journal of Infectious Diseases, vol. 193, no. 6, 2006, pp. 792-5.
Liu W, Fontanet A, Zhang PH, et al. Two-year prospective study of the humoral immune response of patients with severe acute respiratory syndrome. J Infect Dis. 2006;193(6):792-5.
Liu, W., Fontanet, A., Zhang, P. H., Zhan, L., Xin, Z. T., Baril, L., Tang, F., Lv, H., & Cao, W. C. (2006). Two-year prospective study of the humoral immune response of patients with severe acute respiratory syndrome. The Journal of Infectious Diseases, 193(6), 792-5.
Liu W, et al. Two-year Prospective Study of the Humoral Immune Response of Patients With Severe Acute Respiratory Syndrome. J Infect Dis. 2006 Mar 15;193(6):792-5. PubMed PMID: 16479513.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Two-year prospective study of the humoral immune response of patients with severe acute respiratory syndrome. AU - Liu,Wei, AU - Fontanet,Arnaud, AU - Zhang,Pan-He, AU - Zhan,Lin, AU - Xin,Zhong-Tao, AU - Baril,Laurence, AU - Tang,Fang, AU - Lv,Hui, AU - Cao,Wu-Chun, Y1 - 2006/02/09/ PY - 2005/07/04/received PY - 2005/09/15/accepted PY - 2006/2/16/pubmed PY - 2006/6/7/medline PY - 2006/2/16/entrez SP - 792 EP - 5 JF - The Journal of infectious diseases JO - J Infect Dis VL - 193 IS - 6 N2 - In a cohort study of 56 convalescent patients with severe acute respiratory syndrome (SARS), titers of immunoglobulin G (IgG) antibodies and neutralizing antibodies (NAbs) against SARS-associated coronavirus were assessed at regular intervals (at 1, 4, 7, 10, 16, and 24 months after the onset of disease) by use of enzyme-linked immunosorbent assay and neutralization assay. IgG antibody and NAb titers were highly correlated, peaking at month 4 after the onset of disease and decreasing thereafter. IgG antibodies remained detectable in all patients until month 16, and they became undetectable in 11.8% of patients at month 24. The finding that NAbs remained detectable throughout follow-up is reassuring in terms of protection provided against reinfection; however, NAb titers decreased markedly after month 16. SN - 0022-1899 UR - https://www.unboundmedicine.com/medline/citation/16479513/Two_year_prospective_study_of_the_humoral_immune_response_of_patients_with_severe_acute_respiratory_syndrome_ DB - PRIME DP - Unbound Medicine ER -