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[Pharmacokinetics of breviscapine in dogs and rabbits following single intravenous administration].
Zhong Yao Cai. 2005 Oct; 28(10):913-6.ZY

Abstract

OBJECTIVE

To study pharmacokinetics of breviscapine in dogs and rabbits after iv. single dose.

METHODS

Lc/Lc extract was used to prepare test samples and HPLC was used to determine breviscapine.

RESULTS

Breviscaplin was fitted to double-department model in dogs and rabbits after iv. single dose. The main parameters in dogs were: A = 56.93 +/- 23.14, B = 1.61 +/- 1.11, alpha = 0.2328 +/- 0.1321 min, beta = 0.0255 +/- 0.0187 min(-1), t(1/2alpha) = 2.98 +/- 1.42 min, t(1/2beta) = 27.14 +/- 14.35 min, K21 = 0.10312 +/- 0.0112 min(-1), K10 = 0.1904 +/- 0.1319 min(-1), K12 = 0.0367 +/- 0.0306 min(-1), CL = 39.41 +/- 20.44 ml x min(-1), AUC = 3074 +/- 1055 mg x min x L(-1), respectively. The main parameters in rabbits were:A = 2.64 +/- 1.12, B = 0.28 +/- 0.12, alpha = 0.1439 +/- 0.0681 min(-1), beta = 0.0162 +/- 0.0456 min(-1), t1/2alpha = 4.82 +/- 1.65 min, th1/2beta = 42.66 +/- 18.77 min, K21 = 0.0285 +/- 0.0147 min(-1), K10 = 0.0820 +/- 0.00378 min(-1), K12 = 0.0496 +/- 0.0241 min, CL = 337.05 +/- 156.48ml x min(-1), AUC = 356 +/- 114 mg x min x L(-1), respectively.

CONCLUSION

Breviscapine has short half-life after intravenous administration to dogs and rabbits,which show breviscapine is eliminated rapidly and has short action time.

Authors+Show Affiliations

Liu Q
Institute of Material Medica, Tsinghua University, Beijing 100084.
Luo G
No affiliation info available
Wang Y
No affiliation info available
Ma Y
No affiliation info available
Zhang R
No affiliation info available

MeSH

AnimalsArea Under CurveChromatography, High Pressure LiquidDogsDrug StabilityDrugs, Chinese HerbalErigeronFemaleFlavonoidsHalf-LifeInjections, IntravenousMaleMethanolPlants, Medicinal

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

16479930

Citation

Liu, Qingfei, et al. "[Pharmacokinetics of Breviscapine in Dogs and Rabbits Following Single Intravenous Administration]." Zhong Yao Cai = Zhongyaocai = Journal of Chinese Medicinal Materials, vol. 28, no. 10, 2005, pp. 913-6.
Liu Q, Luo G, Wang Y, et al. [Pharmacokinetics of breviscapine in dogs and rabbits following single intravenous administration]. Zhong Yao Cai. 2005;28(10):913-6.
Liu, Q., Luo, G., Wang, Y., Ma, Y., & Zhang, R. (2005). [Pharmacokinetics of breviscapine in dogs and rabbits following single intravenous administration]. Zhong Yao Cai = Zhongyaocai = Journal of Chinese Medicinal Materials, 28(10), 913-6.
Liu Q, et al. [Pharmacokinetics of Breviscapine in Dogs and Rabbits Following Single Intravenous Administration]. Zhong Yao Cai. 2005;28(10):913-6. PubMed PMID: 16479930.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Pharmacokinetics of breviscapine in dogs and rabbits following single intravenous administration]. AU - Liu,Qingfei, AU - Luo,Guoan, AU - Wang,Yiming, AU - Ma,Yuhui, AU - Zhang,Rongli, PY - 2006/2/17/pubmed PY - 2006/10/14/medline PY - 2006/2/17/entrez SP - 913 EP - 6 JF - Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials JO - Zhong Yao Cai VL - 28 IS - 10 N2 - OBJECTIVE: To study pharmacokinetics of breviscapine in dogs and rabbits after iv. single dose. METHODS: Lc/Lc extract was used to prepare test samples and HPLC was used to determine breviscapine. RESULTS: Breviscaplin was fitted to double-department model in dogs and rabbits after iv. single dose. The main parameters in dogs were: A = 56.93 +/- 23.14, B = 1.61 +/- 1.11, alpha = 0.2328 +/- 0.1321 min, beta = 0.0255 +/- 0.0187 min(-1), t(1/2alpha) = 2.98 +/- 1.42 min, t(1/2beta) = 27.14 +/- 14.35 min, K21 = 0.10312 +/- 0.0112 min(-1), K10 = 0.1904 +/- 0.1319 min(-1), K12 = 0.0367 +/- 0.0306 min(-1), CL = 39.41 +/- 20.44 ml x min(-1), AUC = 3074 +/- 1055 mg x min x L(-1), respectively. The main parameters in rabbits were:A = 2.64 +/- 1.12, B = 0.28 +/- 0.12, alpha = 0.1439 +/- 0.0681 min(-1), beta = 0.0162 +/- 0.0456 min(-1), t1/2alpha = 4.82 +/- 1.65 min, th1/2beta = 42.66 +/- 18.77 min, K21 = 0.0285 +/- 0.0147 min(-1), K10 = 0.0820 +/- 0.00378 min(-1), K12 = 0.0496 +/- 0.0241 min, CL = 337.05 +/- 156.48ml x min(-1), AUC = 356 +/- 114 mg x min x L(-1), respectively. CONCLUSION: Breviscapine has short half-life after intravenous administration to dogs and rabbits,which show breviscapine is eliminated rapidly and has short action time. SN - 1001-4454 UR - https://www.unboundmedicine.com/medline/citation/16479930/[Pharmacokinetics_of_breviscapine_in_dogs_and_rabbits_following_single_intravenous_administration]_ DB - PRIME DP - Unbound Medicine ER -