Tags

Type your tag names separated by a space and hit enter

Involvement of IL-31 on scratching behavior in NC/Nga mice with atopic-like dermatitis.
Exp Dermatol. 2006 Mar; 15(3):161-7.ED

Abstract

Pruritus is an important symptom in atopic dermatitis (AD), but the major pruritogen has not been identified. NC/Nga mice, spontaneously develop an eczematous AD-like skin lesion when kept under conventional conditions, but not under specific pathogen-free (SPF) conditions, have been thought to be an animal model for AD. In this study, to determine whether newly identified cytokine, IL-31, may be involved in pruritus of AD, we examined the IL-31 expression in spontaneous dermatitis model which showed itch-associated long-lasting (over 1.5 s duration) scratching behavior and compared with that of hapten-induced contact dermatitis model without itch-associated long-lasting scratching behavior, using NC/Nga mice. In NC/Nga mice cohabited with NC/Nga mice which developed severe dermatitis for 2 weeks (conventional NC/Nga mice), the numbers of long-lasting scratching counts were significantly increased. Yet in 2,4,6-trinitrochlorobenzene (TNCB)-sensitized and challenged mice (TNCB-applied NC/Nga mice), no significant increase in long-lasting scratching counts was observed. In conventional NC/Nga mice with long-lasting scratching behavior, expression of IL-31 mRNA was increased, while in TNCB-applied NC/Nga mice without long-lasting scratching behavior, the expression of IL-31 mRNA were unchanged. There was a good correlation between the scratching counts and expression of IL-31 mRNA in conventional NC/Nga mice, but not so in TNCB-applied NC/Nga mice. These results suggest that IL-31 causes the itch-associated scratching behavior in conventional NC/Nga mice, an experimental animal model for AD.

Authors+Show Affiliations

Medicinal Pharmacology Laboratory, Taisho Pharmaceutical Co. Ltd, 1-403 Yoshino-cho, Kita-ku, Saitama 331-9530, Japan. a.takaoka@po.rd.taisho.co.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16480423

Citation

Takaoka, A, et al. "Involvement of IL-31 On Scratching Behavior in NC/Nga Mice With Atopic-like Dermatitis." Experimental Dermatology, vol. 15, no. 3, 2006, pp. 161-7.
Takaoka A, Arai I, Sugimoto M, et al. Involvement of IL-31 on scratching behavior in NC/Nga mice with atopic-like dermatitis. Exp Dermatol. 2006;15(3):161-7.
Takaoka, A., Arai, I., Sugimoto, M., Honma, Y., Futaki, N., Nakamura, A., & Nakaike, S. (2006). Involvement of IL-31 on scratching behavior in NC/Nga mice with atopic-like dermatitis. Experimental Dermatology, 15(3), 161-7.
Takaoka A, et al. Involvement of IL-31 On Scratching Behavior in NC/Nga Mice With Atopic-like Dermatitis. Exp Dermatol. 2006;15(3):161-7. PubMed PMID: 16480423.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Involvement of IL-31 on scratching behavior in NC/Nga mice with atopic-like dermatitis. AU - Takaoka,A, AU - Arai,I, AU - Sugimoto,M, AU - Honma,Y, AU - Futaki,N, AU - Nakamura,A, AU - Nakaike,S, PY - 2006/2/17/pubmed PY - 2006/6/6/medline PY - 2006/2/17/entrez SP - 161 EP - 7 JF - Experimental dermatology JO - Exp Dermatol VL - 15 IS - 3 N2 - Pruritus is an important symptom in atopic dermatitis (AD), but the major pruritogen has not been identified. NC/Nga mice, spontaneously develop an eczematous AD-like skin lesion when kept under conventional conditions, but not under specific pathogen-free (SPF) conditions, have been thought to be an animal model for AD. In this study, to determine whether newly identified cytokine, IL-31, may be involved in pruritus of AD, we examined the IL-31 expression in spontaneous dermatitis model which showed itch-associated long-lasting (over 1.5 s duration) scratching behavior and compared with that of hapten-induced contact dermatitis model without itch-associated long-lasting scratching behavior, using NC/Nga mice. In NC/Nga mice cohabited with NC/Nga mice which developed severe dermatitis for 2 weeks (conventional NC/Nga mice), the numbers of long-lasting scratching counts were significantly increased. Yet in 2,4,6-trinitrochlorobenzene (TNCB)-sensitized and challenged mice (TNCB-applied NC/Nga mice), no significant increase in long-lasting scratching counts was observed. In conventional NC/Nga mice with long-lasting scratching behavior, expression of IL-31 mRNA was increased, while in TNCB-applied NC/Nga mice without long-lasting scratching behavior, the expression of IL-31 mRNA were unchanged. There was a good correlation between the scratching counts and expression of IL-31 mRNA in conventional NC/Nga mice, but not so in TNCB-applied NC/Nga mice. These results suggest that IL-31 causes the itch-associated scratching behavior in conventional NC/Nga mice, an experimental animal model for AD. SN - 0906-6705 UR - https://www.unboundmedicine.com/medline/citation/16480423/Involvement_of_IL_31_on_scratching_behavior_in_NC/Nga_mice_with_atopic_like_dermatitis_ L2 - https://doi.org/10.1111/j.1600-0625.2006.00405.x DB - PRIME DP - Unbound Medicine ER -