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Could a federal program to promote influenza vaccination among elders be cost-effective?
Prev Med. 2006 Mar; 42(3):240-6.PM

Abstract

BACKGROUND

Influenza-related mortality predominately and disproportionately impacts the elderly. Rates of annual influenza vaccination among the elderly are approximately 65%, far below the Healthy People 2010 target of 90%. We estimated the cost-effectiveness of a 10-year federal program to promote influenza vaccine, intended to increase vaccination rates among persons > or = 65 years old.

METHODS

Published estimates regarding influenza-associated mortality rates and vaccine efficacy among the US elderly were used to calculate the number needed to vaccinate (NNV) to prevent one all-cause death due to influenza, as well as the mortality reduction expected from increased vaccination rates. The costs per life-year saved were estimated for a hypothetical federal promotional campaign, patterned after a direct-to-consumer (DTC) advertising program (2006-2015). The base case scenario presumed a 25-percentage-point increase in vaccination rates to 90%; in sensitivity analyses, we examined programs that increased rates by 10-20 points.

RESULTS

The base case NNV was 1116 (95% CI: 993-1348). Over the 10-year DTC-style influenza vaccine promotion program, 6516 (5576-7435) elderly lives would be saved. The incremental cost-effectiveness (C/E) of the program was dollar 16,300 (dollar 11,347-dollar 25,174) per life-year saved in 2006 and increased to dollar 199,906 (dollar 138,613-dollar 307,423) per life-year saved by 2015. Overall, the C/E for the 10-year program was dollar 37,621 (dollar 32,644-dollar 43,939) per life-year saved. Programs that yielded a 15-percentage-point increase or less in vaccination rates would have C/E values exceeding dollar 50,000 per life-year saved and save fewer than 4000 total lives.

CONCLUSIONS

DTC-style promotional campaigns for influenza vaccine among elders may represent a cost-effective strategy for the federal government to pursue as a means of increasing elders' vaccination rates and reducing influenza-related mortality.

Authors+Show Affiliations

University of Michigan Medical School, Ann Arbor, MI 48109-0456, USA.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16480761

Citation

Patel, Mitesh S., and Matthew M. Davis. "Could a Federal Program to Promote Influenza Vaccination Among Elders Be Cost-effective?" Preventive Medicine, vol. 42, no. 3, 2006, pp. 240-6.
Patel MS, Davis MM. Could a federal program to promote influenza vaccination among elders be cost-effective? Prev Med. 2006;42(3):240-6.
Patel, M. S., & Davis, M. M. (2006). Could a federal program to promote influenza vaccination among elders be cost-effective? Preventive Medicine, 42(3), 240-6.
Patel MS, Davis MM. Could a Federal Program to Promote Influenza Vaccination Among Elders Be Cost-effective. Prev Med. 2006;42(3):240-6. PubMed PMID: 16480761.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Could a federal program to promote influenza vaccination among elders be cost-effective? AU - Patel,Mitesh S, AU - Davis,Matthew M, Y1 - 2006/02/15/ PY - 2005/08/29/received PY - 2005/12/02/revised PY - 2005/12/10/accepted PY - 2006/2/17/pubmed PY - 2007/1/31/medline PY - 2006/2/17/entrez SP - 240 EP - 6 JF - Preventive medicine JO - Prev Med VL - 42 IS - 3 N2 - BACKGROUND: Influenza-related mortality predominately and disproportionately impacts the elderly. Rates of annual influenza vaccination among the elderly are approximately 65%, far below the Healthy People 2010 target of 90%. We estimated the cost-effectiveness of a 10-year federal program to promote influenza vaccine, intended to increase vaccination rates among persons > or = 65 years old. METHODS: Published estimates regarding influenza-associated mortality rates and vaccine efficacy among the US elderly were used to calculate the number needed to vaccinate (NNV) to prevent one all-cause death due to influenza, as well as the mortality reduction expected from increased vaccination rates. The costs per life-year saved were estimated for a hypothetical federal promotional campaign, patterned after a direct-to-consumer (DTC) advertising program (2006-2015). The base case scenario presumed a 25-percentage-point increase in vaccination rates to 90%; in sensitivity analyses, we examined programs that increased rates by 10-20 points. RESULTS: The base case NNV was 1116 (95% CI: 993-1348). Over the 10-year DTC-style influenza vaccine promotion program, 6516 (5576-7435) elderly lives would be saved. The incremental cost-effectiveness (C/E) of the program was dollar 16,300 (dollar 11,347-dollar 25,174) per life-year saved in 2006 and increased to dollar 199,906 (dollar 138,613-dollar 307,423) per life-year saved by 2015. Overall, the C/E for the 10-year program was dollar 37,621 (dollar 32,644-dollar 43,939) per life-year saved. Programs that yielded a 15-percentage-point increase or less in vaccination rates would have C/E values exceeding dollar 50,000 per life-year saved and save fewer than 4000 total lives. CONCLUSIONS: DTC-style promotional campaigns for influenza vaccine among elders may represent a cost-effective strategy for the federal government to pursue as a means of increasing elders' vaccination rates and reducing influenza-related mortality. SN - 0091-7435 UR - https://www.unboundmedicine.com/medline/citation/16480761/Could_a_federal_program_to_promote_influenza_vaccination_among_elders_be_cost_effective L2 - https://linkinghub.elsevier.com/retrieve/pii/S0091-7435(05)00239-2 DB - PRIME DP - Unbound Medicine ER -