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Do recommended high-risk adults benefit from a first influenza vaccination?

Abstract

It is unknown whether a first influenza vaccination protects high-risk adults from severe morbidity and mortality during influenza epidemics. As part of the PRISMA nested case-control study, we aimed to evaluate the effectiveness of first-time and repeat influenza vaccinations in adult persons recommended for vaccination aged between 18 and 64 years during the 1999-2000 influenza A epidemic. After adjustments, 69% of hospitalizations for acute respiratory or cardiovascular disease or death were prevented in first-time vaccinees (95% percent confidence interval [95% CI]: 8-90%). The corresponding figure in persons who were vaccinated before was 85% (95% CI: 36-96%). Adult persons with high-risk medical conditions can substantially benefit from a first and repeat influenza vaccination prior to an epidemic.

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  • Authors+Show Affiliations

    ,

    Julius Center for Health Sciences and Primary Health Care, University Medical Center Utrecht, HP 6.139, P.O. Box 85060, 3508 AB Utrecht, The Netherlands. e.hak@med.uu.nl

    , ,

    Source

    Vaccine 24:15 2006 Apr 05 pg 2799-802

    MeSH

    Adult
    Case-Control Studies
    Cohort Studies
    Disease Outbreaks
    Female
    Hospitalization
    Humans
    Influenza Vaccines
    Influenza, Human
    Male
    Middle Aged
    Respiratory Tract Infections
    Risk Factors

    Pub Type(s)

    Clinical Trial
    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    16480796

    Citation

    Hak, E, et al. "Do Recommended High-risk Adults Benefit From a First Influenza Vaccination?" Vaccine, vol. 24, no. 15, 2006, pp. 2799-802.
    Hak E, Buskens E, Nichol KL, et al. Do recommended high-risk adults benefit from a first influenza vaccination? Vaccine. 2006;24(15):2799-802.
    Hak, E., Buskens, E., Nichol, K. L., & Verheij, T. J. (2006). Do recommended high-risk adults benefit from a first influenza vaccination? Vaccine, 24(15), pp. 2799-802.
    Hak E, et al. Do Recommended High-risk Adults Benefit From a First Influenza Vaccination. Vaccine. 2006 Apr 5;24(15):2799-802. PubMed PMID: 16480796.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Do recommended high-risk adults benefit from a first influenza vaccination? AU - Hak,E, AU - Buskens,E, AU - Nichol,K L, AU - Verheij,T J M, Y1 - 2006/01/18/ PY - 2005/09/22/received PY - 2005/12/20/revised PY - 2006/01/02/accepted PY - 2006/2/17/pubmed PY - 2006/10/27/medline PY - 2006/2/17/entrez SP - 2799 EP - 802 JF - Vaccine JO - Vaccine VL - 24 IS - 15 N2 - It is unknown whether a first influenza vaccination protects high-risk adults from severe morbidity and mortality during influenza epidemics. As part of the PRISMA nested case-control study, we aimed to evaluate the effectiveness of first-time and repeat influenza vaccinations in adult persons recommended for vaccination aged between 18 and 64 years during the 1999-2000 influenza A epidemic. After adjustments, 69% of hospitalizations for acute respiratory or cardiovascular disease or death were prevented in first-time vaccinees (95% percent confidence interval [95% CI]: 8-90%). The corresponding figure in persons who were vaccinated before was 85% (95% CI: 36-96%). Adult persons with high-risk medical conditions can substantially benefit from a first and repeat influenza vaccination prior to an epidemic. SN - 0264-410X UR - https://www.unboundmedicine.com/medline/citation/16480796/Do_recommended_high_risk_adults_benefit_from_a_first_influenza_vaccination L2 - https://linkinghub.elsevier.com/retrieve/pii/S0264-410X(06)00015-6 DB - PRIME DP - Unbound Medicine ER -