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Synergism between paracetamol and nonsteroidal anti-inflammatory drugs in experimental acute pain.
Pain. 2006 Mar; 121(1-2):22-8.PAIN

Abstract

The antinociception induced by the intraperitoneal coadministration of combinations of paracetamol with the nonsteroidal anti-inflammatory drugs (NSAIDs) diclofenac, ibuprofen, ketoprofen, meloxicam, metamizol, naproxen, nimesulide, parecoxib and piroxicam was studied by isobolographic analysis in the acetic acid abdominal constriction test of mice (writhing test). The effective dose that produced 50% antinociception (ED50) was calculated from the log dose-response curves of fixed ratio combinations of paracetamol with each NSAID. By isobolographic analysis, this ED50 was compared to the theoretical additive ED50 calculated from the ED(50) of paracetamol and of each NSAID alone obtained from ED50 dose-response curves. As shown by isobolographic analysis, all the combinations were synergistic, the experimental ED50s being significantly smaller than the theoretically calculated ED50s. The results of this study demonstrate potent interactions between paracetamol and NSAIDs and validate the clinical use of combinations of these drugs in the treatment of pain conditions.

Authors+Show Affiliations

Pharmacology Program, ICBM, Faculty of Medicine, University of Chile, Clasificador 70.000, Santiago 7, Chile. hmiranda@med.uchile.clNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16480830

Citation

Miranda, Hugo F., et al. "Synergism Between Paracetamol and Nonsteroidal Anti-inflammatory Drugs in Experimental Acute Pain." Pain, vol. 121, no. 1-2, 2006, pp. 22-8.
Miranda HF, Puig MM, Prieto JC, et al. Synergism between paracetamol and nonsteroidal anti-inflammatory drugs in experimental acute pain. Pain. 2006;121(1-2):22-8.
Miranda, H. F., Puig, M. M., Prieto, J. C., & Pinardi, G. (2006). Synergism between paracetamol and nonsteroidal anti-inflammatory drugs in experimental acute pain. Pain, 121(1-2), 22-8.
Miranda HF, et al. Synergism Between Paracetamol and Nonsteroidal Anti-inflammatory Drugs in Experimental Acute Pain. Pain. 2006;121(1-2):22-8. PubMed PMID: 16480830.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Synergism between paracetamol and nonsteroidal anti-inflammatory drugs in experimental acute pain. AU - Miranda,Hugo F, AU - Puig,Margarita M, AU - Prieto,Juan Carlos, AU - Pinardi,Gianni, Y1 - 2006/02/09/ PY - 2005/06/09/received PY - 2005/11/03/revised PY - 2005/11/21/accepted PY - 2006/2/17/pubmed PY - 2006/6/3/medline PY - 2006/2/17/entrez SP - 22 EP - 8 JF - Pain JO - Pain VL - 121 IS - 1-2 N2 - The antinociception induced by the intraperitoneal coadministration of combinations of paracetamol with the nonsteroidal anti-inflammatory drugs (NSAIDs) diclofenac, ibuprofen, ketoprofen, meloxicam, metamizol, naproxen, nimesulide, parecoxib and piroxicam was studied by isobolographic analysis in the acetic acid abdominal constriction test of mice (writhing test). The effective dose that produced 50% antinociception (ED50) was calculated from the log dose-response curves of fixed ratio combinations of paracetamol with each NSAID. By isobolographic analysis, this ED50 was compared to the theoretical additive ED50 calculated from the ED(50) of paracetamol and of each NSAID alone obtained from ED50 dose-response curves. As shown by isobolographic analysis, all the combinations were synergistic, the experimental ED50s being significantly smaller than the theoretically calculated ED50s. The results of this study demonstrate potent interactions between paracetamol and NSAIDs and validate the clinical use of combinations of these drugs in the treatment of pain conditions. SN - 0304-3959 UR - https://www.unboundmedicine.com/medline/citation/16480830/Synergism_between_paracetamol_and_nonsteroidal_anti_inflammatory_drugs_in_experimental_acute_pain_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0304-3959(05)00596-8 DB - PRIME DP - Unbound Medicine ER -