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The effects of t10,c12 CLA isomer compared with c9,t11 CLA isomer on lipid metabolism and body composition in hamsters.
J Nutr Biochem. 2006 Sep; 17(9):597-603.JN

Abstract

The objective of the present study was to examine the effects of two different isomers of conjugated linoleic acid (CLA), c9,t11 CLA and t10,c12 CLA, compared with linoleic acid (LA) used as control, on body composition, lipoprotein profile, hepatic lipids and fecal fat content in hamsters. Animals were assigned to the three diet groups (n=15) during 28 days. The diet was composed of 2% of the experimental fat, and throughout the experimental protocol, the hamsters experienced similar food intake. No significant differences were noted in body weight gain among the three diet groups. However, the t10,c12 CLA-fed animals showed higher low-density lipoprotein cholesterol (LDL-C) concentrations (0.9+/-0.1 mmol/L) than those who ingested either LA (0.6+/-0.1 mmol/L) or c9,t11 CLA isomer (0.7+/-0.1 mmol/L), although the t10,c12 CLA consumption decreased hepatic cholesterol and triglycerides and increased fecal fat content compared with the other two groups. Under the present experimental conditions, the dietary c9,t11 CLA isomer showed no positive beneficial effect on plasma lipids. Furthermore, the t10,c12 CLA isomer induced undesirable higher LDL-C, although it reduced hepatic lipids and fat digestibility in hamsters.

Authors+Show Affiliations

Department of Food Science and Nutrition, Laval University, Quebec, Canada.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16481156

Citation

Bissonauth, Vishnee, et al. "The Effects of T10,c12 CLA Isomer Compared With C9,t11 CLA Isomer On Lipid Metabolism and Body Composition in Hamsters." The Journal of Nutritional Biochemistry, vol. 17, no. 9, 2006, pp. 597-603.
Bissonauth V, Chouinard Y, Marin J, et al. The effects of t10,c12 CLA isomer compared with c9,t11 CLA isomer on lipid metabolism and body composition in hamsters. J Nutr Biochem. 2006;17(9):597-603.
Bissonauth, V., Chouinard, Y., Marin, J., Leblanc, N., Richard, D., & Jacques, H. (2006). The effects of t10,c12 CLA isomer compared with c9,t11 CLA isomer on lipid metabolism and body composition in hamsters. The Journal of Nutritional Biochemistry, 17(9), 597-603.
Bissonauth V, et al. The Effects of T10,c12 CLA Isomer Compared With C9,t11 CLA Isomer On Lipid Metabolism and Body Composition in Hamsters. J Nutr Biochem. 2006;17(9):597-603. PubMed PMID: 16481156.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effects of t10,c12 CLA isomer compared with c9,t11 CLA isomer on lipid metabolism and body composition in hamsters. AU - Bissonauth,Vishnee, AU - Chouinard,Yvan, AU - Marin,Johanne, AU - Leblanc,Nadine, AU - Richard,Denis, AU - Jacques,Hélène, Y1 - 2005/11/17/ PY - 2005/07/22/received PY - 2005/10/07/revised PY - 2005/10/17/accepted PY - 2006/2/17/pubmed PY - 2006/10/5/medline PY - 2006/2/17/entrez SP - 597 EP - 603 JF - The Journal of nutritional biochemistry JO - J Nutr Biochem VL - 17 IS - 9 N2 - The objective of the present study was to examine the effects of two different isomers of conjugated linoleic acid (CLA), c9,t11 CLA and t10,c12 CLA, compared with linoleic acid (LA) used as control, on body composition, lipoprotein profile, hepatic lipids and fecal fat content in hamsters. Animals were assigned to the three diet groups (n=15) during 28 days. The diet was composed of 2% of the experimental fat, and throughout the experimental protocol, the hamsters experienced similar food intake. No significant differences were noted in body weight gain among the three diet groups. However, the t10,c12 CLA-fed animals showed higher low-density lipoprotein cholesterol (LDL-C) concentrations (0.9+/-0.1 mmol/L) than those who ingested either LA (0.6+/-0.1 mmol/L) or c9,t11 CLA isomer (0.7+/-0.1 mmol/L), although the t10,c12 CLA consumption decreased hepatic cholesterol and triglycerides and increased fecal fat content compared with the other two groups. Under the present experimental conditions, the dietary c9,t11 CLA isomer showed no positive beneficial effect on plasma lipids. Furthermore, the t10,c12 CLA isomer induced undesirable higher LDL-C, although it reduced hepatic lipids and fat digestibility in hamsters. SN - 0955-2863 UR - https://www.unboundmedicine.com/medline/citation/16481156/The_effects_of_t10c12_CLA_isomer_compared_with_c9t11_CLA_isomer_on_lipid_metabolism_and_body_composition_in_hamsters_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0955-2863(05)00273-1 DB - PRIME DP - Unbound Medicine ER -