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Is there an association between pre-existing sleep apnoea and the development of glaucoma?

Abstract

AIM

To determine if sleep apnoea is associated with an increased risk of developing glaucoma.

METHODS

This was a nested case-control study. Patients seen at the Veterans Affairs Medical Center (BVAMC) in Birmingham, Alabama, with newly diagnosed glaucoma (cases) between 1997 through 2001 were selected (n = 667) and age matched with non-glaucomatous controls (n = 6667). Patient information was extracted from the BVAMC data files containing demographic, clinical, and medication information. An index date was assigned to the glaucoma subjects corresponding to the time of diagnosis. Patients who had a glaucoma diagnosis before the observation period of the study were excluded. 10 controls were randomly selected for each case and matched on age (plus or minus 1 year) and an encounter on or before the index date of the matched case. Ihe main outcome measures were crude and adjusted relative risks for the association between the previous diagnosis of sleep apnoea and the development glaucoma. Adjustment was performed for the associations of diabetes, lipid metabolism disorders, hypertension, cardiovascular disease, cerebrovascular disease, arterial disease, and migraines.

RESULTS

Individuals who developed glaucoma were more likely to have a previous sleep apnoea diagnosis relative to control subjects. However, this finding was of borderline significance at an alpha of 0.05 (p value = 0.06, odds ratio = 2.20, 95% confidence intervals 0.967 to 5.004). Following adjustment for other potential risk factors, no significant difference was seen (p value = 0.18, odds ratio = 1.80, 95% confidence interval 0.76 to 4.23).

CONCLUSIONS

This nested case-control study does not support a large impact of sleep apnoea on the eventual development of glaucoma relative to other putative risk factors.

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  • Authors+Show Affiliations

    ,

    UAB Department of Ophthalmology, 1800 University Blvd, EFH 609, Birmingham, AL 35294-0009, USA. cgirkin@uab.edu

    , ,

    Source

    The British journal of ophthalmology 90:6 2006 Jun pg 679-81

    MeSH

    Aged
    Alabama
    Case-Control Studies
    Glaucoma
    Humans
    Male
    Middle Aged
    Risk Factors
    Sleep Apnea Syndromes

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Extramural
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    16481379

    Citation

    Girkin, C A., et al. "Is There an Association Between Pre-existing Sleep Apnoea and the Development of Glaucoma?" The British Journal of Ophthalmology, vol. 90, no. 6, 2006, pp. 679-81.
    Girkin CA, McGwin G, McNeal SF, et al. Is there an association between pre-existing sleep apnoea and the development of glaucoma? Br J Ophthalmol. 2006;90(6):679-81.
    Girkin, C. A., McGwin, G., McNeal, S. F., & Owsley, C. (2006). Is there an association between pre-existing sleep apnoea and the development of glaucoma? The British Journal of Ophthalmology, 90(6), pp. 679-81.
    Girkin CA, et al. Is There an Association Between Pre-existing Sleep Apnoea and the Development of Glaucoma. Br J Ophthalmol. 2006;90(6):679-81. PubMed PMID: 16481379.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Is there an association between pre-existing sleep apnoea and the development of glaucoma? AU - Girkin,C A, AU - McGwin,G,Jr AU - McNeal,S F, AU - Owsley,C, Y1 - 2006/02/15/ PY - 2006/2/17/pubmed PY - 2006/6/14/medline PY - 2006/2/17/entrez SP - 679 EP - 81 JF - The British journal of ophthalmology JO - Br J Ophthalmol VL - 90 IS - 6 N2 - AIM: To determine if sleep apnoea is associated with an increased risk of developing glaucoma. METHODS: This was a nested case-control study. Patients seen at the Veterans Affairs Medical Center (BVAMC) in Birmingham, Alabama, with newly diagnosed glaucoma (cases) between 1997 through 2001 were selected (n = 667) and age matched with non-glaucomatous controls (n = 6667). Patient information was extracted from the BVAMC data files containing demographic, clinical, and medication information. An index date was assigned to the glaucoma subjects corresponding to the time of diagnosis. Patients who had a glaucoma diagnosis before the observation period of the study were excluded. 10 controls were randomly selected for each case and matched on age (plus or minus 1 year) and an encounter on or before the index date of the matched case. Ihe main outcome measures were crude and adjusted relative risks for the association between the previous diagnosis of sleep apnoea and the development glaucoma. Adjustment was performed for the associations of diabetes, lipid metabolism disorders, hypertension, cardiovascular disease, cerebrovascular disease, arterial disease, and migraines. RESULTS: Individuals who developed glaucoma were more likely to have a previous sleep apnoea diagnosis relative to control subjects. However, this finding was of borderline significance at an alpha of 0.05 (p value = 0.06, odds ratio = 2.20, 95% confidence intervals 0.967 to 5.004). Following adjustment for other potential risk factors, no significant difference was seen (p value = 0.18, odds ratio = 1.80, 95% confidence interval 0.76 to 4.23). CONCLUSIONS: This nested case-control study does not support a large impact of sleep apnoea on the eventual development of glaucoma relative to other putative risk factors. SN - 0007-1161 UR - https://www.unboundmedicine.com/medline/citation/16481379/Is_there_an_association_between_pre_existing_sleep_apnoea_and_the_development_of_glaucoma L2 - http://bjo.bmj.com/cgi/pmidlookup?view=long&pmid=16481379 DB - PRIME DP - Unbound Medicine ER -