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Plant sterol or stanol consumption does not affect erythrocyte osmotic fragility in patients on statin treatment.
Eur J Clin Nutr. 2006 Aug; 60(8):985-90.EJ

Abstract

OBJECTIVE

To assess the effects of plant sterol or stanol ester consumption on their incorporation into erythrocytes and their effects on osmotic fragility of red blood cells.

DESIGN

Double-blind, randomized, placebo-controlled intervention trial.

SUBJECTS AND INTERVENTION

Forty-one subjects on stable statin treatment - who already have increased serum plant sterol and stanol concentrations - first received for 4 weeks a control margarine. For the next 16 weeks, subjects were randomly assigned to one of three possible interventions. Eleven subjects continued with control margarine, 15 subjects with plant sterol ester enriched and 15 subjects with plant stanol ester-enriched margarine. Daily plant sterol or stanol intake was 2.5 g. Erythrocyte haemolysis was measured spectrophotometrically at five different saline concentrations.

RESULTS

Despite significant (P = 0.004) increases of, respectively, 42 and 59% in cholesterol-standardized serum sitosterol and campesterol concentrations in the plant sterol group as compared to the control group, campesterol levels in the red blood cells did not change (P = 0.196). Osmotic fragility did not change significantly (P = 0.757) in the plant sterol and plant stanol groups as compared to the control group.

CONCLUSION

We conclude that plant sterol and stanol ester consumption for 16 weeks does not change osmotic fragility of erythrocytes in statin-treated patients.

SPONSORSHIP

Netherlands Organisation for Health Research and Development (Program Nutrition: Health, Safety and Sustainability, Grant 014-12-010).

Authors+Show Affiliations

Department of Human Biology, Maastricht University, Maastricht, The Netherlands. na.dejong@hb.unimaas.nlNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16482072

Citation

de Jong, A, et al. "Plant Sterol or Stanol Consumption Does Not Affect Erythrocyte Osmotic Fragility in Patients On Statin Treatment." European Journal of Clinical Nutrition, vol. 60, no. 8, 2006, pp. 985-90.
de Jong A, Plat J, Mensink RP. Plant sterol or stanol consumption does not affect erythrocyte osmotic fragility in patients on statin treatment. Eur J Clin Nutr. 2006;60(8):985-90.
de Jong, A., Plat, J., & Mensink, R. P. (2006). Plant sterol or stanol consumption does not affect erythrocyte osmotic fragility in patients on statin treatment. European Journal of Clinical Nutrition, 60(8), 985-90.
de Jong A, Plat J, Mensink RP. Plant Sterol or Stanol Consumption Does Not Affect Erythrocyte Osmotic Fragility in Patients On Statin Treatment. Eur J Clin Nutr. 2006;60(8):985-90. PubMed PMID: 16482072.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Plant sterol or stanol consumption does not affect erythrocyte osmotic fragility in patients on statin treatment. AU - de Jong,A, AU - Plat,J, AU - Mensink,R P, Y1 - 2006/02/15/ PY - 2006/2/17/pubmed PY - 2006/12/9/medline PY - 2006/2/17/entrez SP - 985 EP - 90 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 60 IS - 8 N2 - OBJECTIVE: To assess the effects of plant sterol or stanol ester consumption on their incorporation into erythrocytes and their effects on osmotic fragility of red blood cells. DESIGN: Double-blind, randomized, placebo-controlled intervention trial. SUBJECTS AND INTERVENTION: Forty-one subjects on stable statin treatment - who already have increased serum plant sterol and stanol concentrations - first received for 4 weeks a control margarine. For the next 16 weeks, subjects were randomly assigned to one of three possible interventions. Eleven subjects continued with control margarine, 15 subjects with plant sterol ester enriched and 15 subjects with plant stanol ester-enriched margarine. Daily plant sterol or stanol intake was 2.5 g. Erythrocyte haemolysis was measured spectrophotometrically at five different saline concentrations. RESULTS: Despite significant (P = 0.004) increases of, respectively, 42 and 59% in cholesterol-standardized serum sitosterol and campesterol concentrations in the plant sterol group as compared to the control group, campesterol levels in the red blood cells did not change (P = 0.196). Osmotic fragility did not change significantly (P = 0.757) in the plant sterol and plant stanol groups as compared to the control group. CONCLUSION: We conclude that plant sterol and stanol ester consumption for 16 weeks does not change osmotic fragility of erythrocytes in statin-treated patients. SPONSORSHIP: Netherlands Organisation for Health Research and Development (Program Nutrition: Health, Safety and Sustainability, Grant 014-12-010). SN - 0954-3007 UR - https://www.unboundmedicine.com/medline/citation/16482072/Plant_sterol_or_stanol_consumption_does_not_affect_erythrocyte_osmotic_fragility_in_patients_on_statin_treatment_ L2 - https://doi.org/10.1038/sj.ejcn.1602409 DB - PRIME DP - Unbound Medicine ER -