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Vitamin C supplementation influences the antioxidant response and nitric oxide handling of erythrocytes and lymphocytes to diving apnea.
Eur J Clin Nutr. 2006 Jul; 60(7):838-46.EJ

Abstract

OBJECTIVE

We have investigated the influence of vitamin C diet supplementation on the antioxidant response and nitrite levels in lymphocytes and erythrocytes during diving apnea.

SUBJECTS

Seven male professional apnea divers participated in a double blind crossover study. Divers were randomly assigned to either vitamin C supplemented or placebo groups. The subjects did not take any other supplements than the ones provided for this study.

INTERVENTION

One group was supplemented with vitamin C capsules (1 g per day) for 7 days while the other group took a placebo composed of lactose. The usual dietary habits of participants were assessed using a self-reported 7-days 24-h recall before the day of the study. Blood samples were taken under basal conditions, immediately after diving apnea for 4 h and after 1 h of recovery.

RESULTS

Catalase activity increased in erythrocytes (23%) and superoxide dismutase increased in lymphocytes (35%) during the recovery only in the placebo group. Lymphocyte ascorbate levels increased in the supplemented group after diving (85%) and maintained high at recovery. Plasma nitrite levels increased about twofold in both groups during the recovery. Erythrocyte nitrite levels increased after diving (50%) and about twofold during the recovery in the supplemented group. Nitrite levels and iNOS levels in lymphocytes were higher in the placebo group than in the supplemented during the recovery. Erythrocyte carbonyl derivates were unchanged in all situations.

CONCLUSIONS

Vitamin C supplementation influenced the antioxidant response and NO handling in erythrocytes and lymphocytes to the oxidative stress induced by hypoxia-reoxygenation.

Authors+Show Affiliations

Laboratori de Ciències de l'Activitat Física, Departament de Biologia Fonamental i Ciències de la Salut, Universitat de les Illes Balears, Spain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16482080

Citation

Sureda, A, et al. "Vitamin C Supplementation Influences the Antioxidant Response and Nitric Oxide Handling of Erythrocytes and Lymphocytes to Diving Apnea." European Journal of Clinical Nutrition, vol. 60, no. 7, 2006, pp. 838-46.
Sureda A, Batle JM, Tauler P, et al. Vitamin C supplementation influences the antioxidant response and nitric oxide handling of erythrocytes and lymphocytes to diving apnea. Eur J Clin Nutr. 2006;60(7):838-46.
Sureda, A., Batle, J. M., Tauler, P., Ferrer, M. D., Tur, J. A., & Pons, A. (2006). Vitamin C supplementation influences the antioxidant response and nitric oxide handling of erythrocytes and lymphocytes to diving apnea. European Journal of Clinical Nutrition, 60(7), 838-46.
Sureda A, et al. Vitamin C Supplementation Influences the Antioxidant Response and Nitric Oxide Handling of Erythrocytes and Lymphocytes to Diving Apnea. Eur J Clin Nutr. 2006;60(7):838-46. PubMed PMID: 16482080.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vitamin C supplementation influences the antioxidant response and nitric oxide handling of erythrocytes and lymphocytes to diving apnea. AU - Sureda,A, AU - Batle,J M, AU - Tauler,P, AU - Ferrer,M D, AU - Tur,J A, AU - Pons,A, Y1 - 2006/02/15/ PY - 2006/2/17/pubmed PY - 2006/12/9/medline PY - 2006/2/17/entrez SP - 838 EP - 46 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 60 IS - 7 N2 - OBJECTIVE: We have investigated the influence of vitamin C diet supplementation on the antioxidant response and nitrite levels in lymphocytes and erythrocytes during diving apnea. SUBJECTS: Seven male professional apnea divers participated in a double blind crossover study. Divers were randomly assigned to either vitamin C supplemented or placebo groups. The subjects did not take any other supplements than the ones provided for this study. INTERVENTION: One group was supplemented with vitamin C capsules (1 g per day) for 7 days while the other group took a placebo composed of lactose. The usual dietary habits of participants were assessed using a self-reported 7-days 24-h recall before the day of the study. Blood samples were taken under basal conditions, immediately after diving apnea for 4 h and after 1 h of recovery. RESULTS: Catalase activity increased in erythrocytes (23%) and superoxide dismutase increased in lymphocytes (35%) during the recovery only in the placebo group. Lymphocyte ascorbate levels increased in the supplemented group after diving (85%) and maintained high at recovery. Plasma nitrite levels increased about twofold in both groups during the recovery. Erythrocyte nitrite levels increased after diving (50%) and about twofold during the recovery in the supplemented group. Nitrite levels and iNOS levels in lymphocytes were higher in the placebo group than in the supplemented during the recovery. Erythrocyte carbonyl derivates were unchanged in all situations. CONCLUSIONS: Vitamin C supplementation influenced the antioxidant response and NO handling in erythrocytes and lymphocytes to the oxidative stress induced by hypoxia-reoxygenation. SN - 0954-3007 UR - https://www.unboundmedicine.com/medline/citation/16482080/Vitamin_C_supplementation_influences_the_antioxidant_response_and_nitric_oxide_handling_of_erythrocytes_and_lymphocytes_to_diving_apnea_ L2 - https://doi.org/10.1038/sj.ejcn.1602388 DB - PRIME DP - Unbound Medicine ER -