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Association of C-reactive protein with the metabolic risk factors among young and middle-aged Koreans.
Metabolism. 2006 Mar; 55(3):415-21.M

Abstract

We investigated the relationship between the clustering of risk factors for metabolic syndrome and the plasma C-reactive protein (CRP) concentration as measured by high-sensitive CRP assay. Body mass index, waist circumference, triglycerides (TGs), high-density lipoprotein cholesterol, fasting glucose, systolic and diastolic blood pressures, insulin, and CRP were measured in 1046 Korean adults (560 males; age, 18-64 years) in 2003 to 2004. There were statistically significant positive correlations for log CRP with body mass index, waist circumference, log TG, log insulin, and log homeostasis model assessment in both sexes after adjusting for age and smoking status. High-density lipoprotein cholesterol showed a significant negative correlation with log CRP in both sexes. For both sexes, the mean level of log CRP increased with increasing number of risk factors of metabolic syndrome (P for trend <.01 for males and <.001 for females). Stepwise multivariate linear regression analysis showed that waist circumference contributed the largest portion of the variance in CRP levels in both sexes. Log homeostasis model assessment and log TG were independently associated with log CRP levels only in females. These results indicate that CRP, a marker of inflammation that underlies atherosclerosis, is associated with the clustering of each metabolic syndrome risk factor and, furthermore, that abdominal obesity is the strongest predictor of CRP level in the Korean adult population.

Authors+Show Affiliations

Department of Family Medicine, Dankook University College of Medicine, Cheonan 330-715, South Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16483888

Citation

Choi, Eun Young, et al. "Association of C-reactive Protein With the Metabolic Risk Factors Among Young and Middle-aged Koreans." Metabolism: Clinical and Experimental, vol. 55, no. 3, 2006, pp. 415-21.
Choi EY, Park EH, Cheong YS, et al. Association of C-reactive protein with the metabolic risk factors among young and middle-aged Koreans. Metabolism. 2006;55(3):415-21.
Choi, E. Y., Park, E. H., Cheong, Y. S., Rheem, I., Park, S. G., & Yoo, S. (2006). Association of C-reactive protein with the metabolic risk factors among young and middle-aged Koreans. Metabolism: Clinical and Experimental, 55(3), 415-21.
Choi EY, et al. Association of C-reactive Protein With the Metabolic Risk Factors Among Young and Middle-aged Koreans. Metabolism. 2006;55(3):415-21. PubMed PMID: 16483888.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association of C-reactive protein with the metabolic risk factors among young and middle-aged Koreans. AU - Choi,Eun Young, AU - Park,Eal Hwan, AU - Cheong,Yoo Seock, AU - Rheem,Insoo, AU - Park,Seouk Gun, AU - Yoo,Sunmi, PY - 2006/2/18/pubmed PY - 2006/6/6/medline PY - 2006/2/18/entrez SP - 415 EP - 21 JF - Metabolism: clinical and experimental JO - Metabolism VL - 55 IS - 3 N2 - We investigated the relationship between the clustering of risk factors for metabolic syndrome and the plasma C-reactive protein (CRP) concentration as measured by high-sensitive CRP assay. Body mass index, waist circumference, triglycerides (TGs), high-density lipoprotein cholesterol, fasting glucose, systolic and diastolic blood pressures, insulin, and CRP were measured in 1046 Korean adults (560 males; age, 18-64 years) in 2003 to 2004. There were statistically significant positive correlations for log CRP with body mass index, waist circumference, log TG, log insulin, and log homeostasis model assessment in both sexes after adjusting for age and smoking status. High-density lipoprotein cholesterol showed a significant negative correlation with log CRP in both sexes. For both sexes, the mean level of log CRP increased with increasing number of risk factors of metabolic syndrome (P for trend <.01 for males and <.001 for females). Stepwise multivariate linear regression analysis showed that waist circumference contributed the largest portion of the variance in CRP levels in both sexes. Log homeostasis model assessment and log TG were independently associated with log CRP levels only in females. These results indicate that CRP, a marker of inflammation that underlies atherosclerosis, is associated with the clustering of each metabolic syndrome risk factor and, furthermore, that abdominal obesity is the strongest predictor of CRP level in the Korean adult population. SN - 0026-0495 UR - https://www.unboundmedicine.com/medline/citation/16483888/Association_of_C_reactive_protein_with_the_metabolic_risk_factors_among_young_and_middle_aged_Koreans_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0026-0495(05)00400-2 DB - PRIME DP - Unbound Medicine ER -