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Aged garlic extract is a potential therapy for sickle-cell anemia.
J Nutr. 2006 03; 136(3 Suppl):803S-805S.JN

Abstract

Sickle-cell anemia is one of the most prevalent hereditary disorders with prominent morbidity and mortality. Oxidative phenomena play a significant role in the disorder's pathophysiology. A forumlation of garlic (Allium sativum), AGE, has been reported to exert an antioxidant effect in vitro. We evaluated the antioxidant effect of AGE on sickle red blood cells (RBCs). Five patients (two men and three women, mean age 40+/-15 years, range 24-58 years) with sickle-cell anemia participated in the study. AGE was administered at a dose of 5 mL daily. Whole blood samples were obtained at baseline and at 4 wk, primarily for Heinz body analysis. In all patients, the number of Heinz bodies decreased over the 4-wk period (58.9+/-20.0% at baseline to 29.8+/-15.3% at follow-up; P=0.03). These data suggest that AGE has a significant antioxidant activity on sickle RBCs. AGE may be further evaluated as a potential therapeutic agent to ameliorate complications of sickle-cell anemia.

Authors+Show Affiliations

Department of Medicine, Harbor-UCLA Medical Center, UCLA School of Medicine, Torrance, CA 90502, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

16484568

Citation

Takasu, Junichiro, et al. "Aged Garlic Extract Is a Potential Therapy for Sickle-cell Anemia." The Journal of Nutrition, vol. 136, no. 3 Suppl, 2006, 803S-805S.
Takasu J, Uykimpang R, Sunga MA, et al. Aged garlic extract is a potential therapy for sickle-cell anemia. J Nutr. 2006;136(3 Suppl):803S-805S.
Takasu, J., Uykimpang, R., Sunga, M. A., Amagase, H., & Niihara, Y. (2006). Aged garlic extract is a potential therapy for sickle-cell anemia. The Journal of Nutrition, 136(3 Suppl), 803S-805S. https://doi.org/10.1093/jn/136.3.803S
Takasu J, et al. Aged Garlic Extract Is a Potential Therapy for Sickle-cell Anemia. J Nutr. 2006;136(3 Suppl):803S-805S. PubMed PMID: 16484568.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Aged garlic extract is a potential therapy for sickle-cell anemia. AU - Takasu,Junichiro, AU - Uykimpang,Rolando, AU - Sunga,Maria Alenor, AU - Amagase,Harunobu, AU - Niihara,Yutaka, PY - 2006/2/18/pubmed PY - 2006/5/4/medline PY - 2006/2/18/entrez SP - 803S EP - 805S JF - The Journal of nutrition JO - J Nutr VL - 136 IS - 3 Suppl N2 - Sickle-cell anemia is one of the most prevalent hereditary disorders with prominent morbidity and mortality. Oxidative phenomena play a significant role in the disorder's pathophysiology. A forumlation of garlic (Allium sativum), AGE, has been reported to exert an antioxidant effect in vitro. We evaluated the antioxidant effect of AGE on sickle red blood cells (RBCs). Five patients (two men and three women, mean age 40+/-15 years, range 24-58 years) with sickle-cell anemia participated in the study. AGE was administered at a dose of 5 mL daily. Whole blood samples were obtained at baseline and at 4 wk, primarily for Heinz body analysis. In all patients, the number of Heinz bodies decreased over the 4-wk period (58.9+/-20.0% at baseline to 29.8+/-15.3% at follow-up; P=0.03). These data suggest that AGE has a significant antioxidant activity on sickle RBCs. AGE may be further evaluated as a potential therapeutic agent to ameliorate complications of sickle-cell anemia. SN - 0022-3166 UR - https://www.unboundmedicine.com/medline/citation/16484568/Aged_garlic_extract_is_a_potential_therapy_for_sickle_cell_anemia_ L2 - https://academic.oup.com/jn/article-lookup/doi/10.1093/jn/136.3.803S DB - PRIME DP - Unbound Medicine ER -