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Aged garlic extract has chemopreventative effects on 1,2-dimethylhydrazine-induced colon tumors in rats.
J Nutr 2006; 136(3 Suppl):847S-851SJN

Abstract

Garlic has been reported to have chemopreventive effects against a variety of cancers. However, different garlic preparations contain different constituents. We investigated the chemopreventive effect of aged garlic extract (AGE), an odorless product from prolonged extraction of fresh garlic, on colon carcinogenesis and cell proliferation in 1,2-dimethylhydrazine (DMH)-induced colon neoplastic rats. Rats were given weekly subcutaneous injections of DMH (20 mg/kg) for 20 wk, and fed either a basal diet or one containing 4% AGE. Serum from AGE-treated rats contained detectable S-allylcysteine. The AGE diet significantly reduced the number of colon tumors and aberrant crypt foci compared to the basal diet. Cell proliferation of normal-appearing colonic mucosa was assessed by MIB-5 immunohistochemistry. AGE treatment significantly decreased the mean MIB-5-labeling index. These findings suggest AGE has a chemopreventive effect on colon carcinogenesis through suppression of cell proliferation.

Authors+Show Affiliations

Department of Surgery 1, University of Occupational and Environmental Health, Kitakyushu, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16484578

Citation

Katsuki, Takefumi, et al. "Aged Garlic Extract Has Chemopreventative Effects On 1,2-dimethylhydrazine-induced Colon Tumors in Rats." The Journal of Nutrition, vol. 136, no. 3 Suppl, 2006, 847S-851S.
Katsuki T, Hirata K, Ishikawa H, et al. Aged garlic extract has chemopreventative effects on 1,2-dimethylhydrazine-induced colon tumors in rats. J Nutr. 2006;136(3 Suppl):847S-851S.
Katsuki, T., Hirata, K., Ishikawa, H., Matsuura, N., Sumi, S., & Itoh, H. (2006). Aged garlic extract has chemopreventative effects on 1,2-dimethylhydrazine-induced colon tumors in rats. The Journal of Nutrition, 136(3 Suppl), 847S-851S. doi:10.1093/jn/136.3.847S.
Katsuki T, et al. Aged Garlic Extract Has Chemopreventative Effects On 1,2-dimethylhydrazine-induced Colon Tumors in Rats. J Nutr. 2006;136(3 Suppl):847S-851S. PubMed PMID: 16484578.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Aged garlic extract has chemopreventative effects on 1,2-dimethylhydrazine-induced colon tumors in rats. AU - Katsuki,Takefumi, AU - Hirata,Keiji, AU - Ishikawa,Hideki, AU - Matsuura,Nariaki, AU - Sumi,Shin-ichiro, AU - Itoh,Hideaki, PY - 2006/2/18/pubmed PY - 2006/5/4/medline PY - 2006/2/18/entrez SP - 847S EP - 851S JF - The Journal of nutrition JO - J. Nutr. VL - 136 IS - 3 Suppl N2 - Garlic has been reported to have chemopreventive effects against a variety of cancers. However, different garlic preparations contain different constituents. We investigated the chemopreventive effect of aged garlic extract (AGE), an odorless product from prolonged extraction of fresh garlic, on colon carcinogenesis and cell proliferation in 1,2-dimethylhydrazine (DMH)-induced colon neoplastic rats. Rats were given weekly subcutaneous injections of DMH (20 mg/kg) for 20 wk, and fed either a basal diet or one containing 4% AGE. Serum from AGE-treated rats contained detectable S-allylcysteine. The AGE diet significantly reduced the number of colon tumors and aberrant crypt foci compared to the basal diet. Cell proliferation of normal-appearing colonic mucosa was assessed by MIB-5 immunohistochemistry. AGE treatment significantly decreased the mean MIB-5-labeling index. These findings suggest AGE has a chemopreventive effect on colon carcinogenesis through suppression of cell proliferation. SN - 0022-3166 UR - https://www.unboundmedicine.com/medline/citation/16484578/Aged_garlic_extract_has_chemopreventative_effects_on_12_dimethylhydrazine_induced_colon_tumors_in_rats_ L2 - https://academic.oup.com/jn/article-lookup/doi/10.1093/jn/136.3.847S DB - PRIME DP - Unbound Medicine ER -