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Allyl sulfur compounds from garlic modulate aberrant crypt formation.
J Nutr 2006; 136(3 Suppl):852S-854SJN

Abstract

The health benefits of garlic, including inhibition of carcinogenesis, are supported by several epidemiologic and laboratory findings. Garlic's sulfur components have been reported to suppress experimentally induced tumor incidence in several organs, including the colon. Studies in humans also suggest that dietary garlic constituents reduce the risk of colorectal adenomatous polyps, which are considered precursors to colon cancer. Aberrant crypt foci (ACF) are proposed to be early preneoplastic lesions of adenoma-carcinoma in humans and chemically induced colon cancer in rodents. In preclinical studies, both water- and lipid-soluble allyl sulfur compounds arising from processed garlic inhibited ACF. The response to these allyl sulfur compounds appears to depend on several factors, including the speciation, quantity, and duration provided.

Authors+Show Affiliations

Nutritional Sciences Research Group, Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, U S Department of Health and Human Services, Rockville, MD 20892-7328, USA. rosssha@mail.nih.govNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

16484579

Citation

Ross, Sharon A., et al. "Allyl Sulfur Compounds From Garlic Modulate Aberrant Crypt Formation." The Journal of Nutrition, vol. 136, no. 3 Suppl, 2006, 852S-854S.
Ross SA, Finley JW, Milner JA. Allyl sulfur compounds from garlic modulate aberrant crypt formation. J Nutr. 2006;136(3 Suppl):852S-854S.
Ross, S. A., Finley, J. W., & Milner, J. A. (2006). Allyl sulfur compounds from garlic modulate aberrant crypt formation. The Journal of Nutrition, 136(3 Suppl), 852S-854S. doi:10.1093/jn/136.3.852S.
Ross SA, Finley JW, Milner JA. Allyl Sulfur Compounds From Garlic Modulate Aberrant Crypt Formation. J Nutr. 2006;136(3 Suppl):852S-854S. PubMed PMID: 16484579.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Allyl sulfur compounds from garlic modulate aberrant crypt formation. AU - Ross,Sharon A, AU - Finley,John W, AU - Milner,John A, PY - 2006/2/18/pubmed PY - 2006/5/4/medline PY - 2006/2/18/entrez SP - 852S EP - 854S JF - The Journal of nutrition JO - J. Nutr. VL - 136 IS - 3 Suppl N2 - The health benefits of garlic, including inhibition of carcinogenesis, are supported by several epidemiologic and laboratory findings. Garlic's sulfur components have been reported to suppress experimentally induced tumor incidence in several organs, including the colon. Studies in humans also suggest that dietary garlic constituents reduce the risk of colorectal adenomatous polyps, which are considered precursors to colon cancer. Aberrant crypt foci (ACF) are proposed to be early preneoplastic lesions of adenoma-carcinoma in humans and chemically induced colon cancer in rodents. In preclinical studies, both water- and lipid-soluble allyl sulfur compounds arising from processed garlic inhibited ACF. The response to these allyl sulfur compounds appears to depend on several factors, including the speciation, quantity, and duration provided. SN - 0022-3166 UR - https://www.unboundmedicine.com/medline/citation/16484579/Allyl_sulfur_compounds_from_garlic_modulate_aberrant_crypt_formation_ L2 - https://academic.oup.com/jn/article-lookup/doi/10.1093/jn/136.3.852S DB - PRIME DP - Unbound Medicine ER -