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Cancer chemoprevention by garlic and garlic-containing sulfur and selenium compounds.
J Nutr 2006; 136(3 Suppl):864S-869SJN

Abstract

As early as 1550 B.C., Egyptians realized the benefits of garlic as a remedy for a variety of diseases. Many epidemiological studies support the protective role of garlic and related allium foods against the development of certain human cancers. Natural garlic and garlic cultivated with selenium fertilization have been shown in laboratory animals to have protective roles in cancer prevention. Certain organoselenium compounds and their sulfur analogs have been identified in plants. Organoselenium compounds synthesized in our laboratory were compared with their sulfur analogs for chemopreventive efficacy. Diallyl selenide was at least 300-fold more effective than diallyl sulfide in protecting against 7,12-dimethylbenz[a]anthracene (DMBA)-induced mammary adenocarcinomas in rats. In addition, benzyl selenocyanate inhibited the development of DMBA-induced mammary adenocarcinomas and azoxymethane-induced colon cancer in rats and benzo[a]pyrene-induced forestomach tumors in mice. The sulfur analog, benzyl thiocyanate, had no effect under the same experimental conditions. Furthermore, we showed that 1,4-phenylenebis(methylene)selenocyanate, but not its sulfur analog, significantly inhibited DMBA-DNA adduct formation and suppressed DMBA-induced mammary carcinogenesis. Collectively, these results indicate that structurally distinctive organoselenium compounds are superior to their corresponding sulfur analogs in cancer chemoprevention. Additionally, synthetic aromatic selenocyanates are more effective cancer chemopreventive agents than the naturally occurring selenoamino acids. Because plants are capable of utilizing selenium in a manner similar to that in sulfur assimilation pathways, future studies should aim at determining whether, under appropriate conditions, these potent cancer chemopreventive synthetic selenium compounds can be synthesized by garlic and related allium foods.

Authors+Show Affiliations

Biochemistry and Molecular Biology, Penn State College of Medicine, Hershey, PA 17033, USA. kee2@psu.eduNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

16484582

Citation

El-Bayoumy, Karam, et al. "Cancer Chemoprevention By Garlic and Garlic-containing Sulfur and Selenium Compounds." The Journal of Nutrition, vol. 136, no. 3 Suppl, 2006, 864S-869S.
El-Bayoumy K, Sinha R, Pinto JT, et al. Cancer chemoprevention by garlic and garlic-containing sulfur and selenium compounds. J Nutr. 2006;136(3 Suppl):864S-869S.
El-Bayoumy, K., Sinha, R., Pinto, J. T., & Rivlin, R. S. (2006). Cancer chemoprevention by garlic and garlic-containing sulfur and selenium compounds. The Journal of Nutrition, 136(3 Suppl), 864S-869S. doi:10.1093/jn/136.3.864S.
El-Bayoumy K, et al. Cancer Chemoprevention By Garlic and Garlic-containing Sulfur and Selenium Compounds. J Nutr. 2006;136(3 Suppl):864S-869S. PubMed PMID: 16484582.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cancer chemoprevention by garlic and garlic-containing sulfur and selenium compounds. AU - El-Bayoumy,Karam, AU - Sinha,Raghu, AU - Pinto,John T, AU - Rivlin,Richard S, PY - 2006/2/18/pubmed PY - 2006/5/4/medline PY - 2006/2/18/entrez SP - 864S EP - 869S JF - The Journal of nutrition JO - J. Nutr. VL - 136 IS - 3 Suppl N2 - As early as 1550 B.C., Egyptians realized the benefits of garlic as a remedy for a variety of diseases. Many epidemiological studies support the protective role of garlic and related allium foods against the development of certain human cancers. Natural garlic and garlic cultivated with selenium fertilization have been shown in laboratory animals to have protective roles in cancer prevention. Certain organoselenium compounds and their sulfur analogs have been identified in plants. Organoselenium compounds synthesized in our laboratory were compared with their sulfur analogs for chemopreventive efficacy. Diallyl selenide was at least 300-fold more effective than diallyl sulfide in protecting against 7,12-dimethylbenz[a]anthracene (DMBA)-induced mammary adenocarcinomas in rats. In addition, benzyl selenocyanate inhibited the development of DMBA-induced mammary adenocarcinomas and azoxymethane-induced colon cancer in rats and benzo[a]pyrene-induced forestomach tumors in mice. The sulfur analog, benzyl thiocyanate, had no effect under the same experimental conditions. Furthermore, we showed that 1,4-phenylenebis(methylene)selenocyanate, but not its sulfur analog, significantly inhibited DMBA-DNA adduct formation and suppressed DMBA-induced mammary carcinogenesis. Collectively, these results indicate that structurally distinctive organoselenium compounds are superior to their corresponding sulfur analogs in cancer chemoprevention. Additionally, synthetic aromatic selenocyanates are more effective cancer chemopreventive agents than the naturally occurring selenoamino acids. Because plants are capable of utilizing selenium in a manner similar to that in sulfur assimilation pathways, future studies should aim at determining whether, under appropriate conditions, these potent cancer chemopreventive synthetic selenium compounds can be synthesized by garlic and related allium foods. SN - 0022-3166 UR - https://www.unboundmedicine.com/medline/citation/16484582/Cancer_chemoprevention_by_garlic_and_garlic_containing_sulfur_and_selenium_compounds_ L2 - https://academic.oup.com/jn/article-lookup/doi/10.1093/jn/136.3.864S DB - PRIME DP - Unbound Medicine ER -