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[Hypertension, heart failure, myocardial infarction, secondary prevention: the role of perindopril].
Ital Heart J 2005; 6 Suppl 7:40S-47SIH

Abstract

Perindopril is a long-acting, once-daily lipophilic angiotensin-converting enzyme inhibitor with high tissue angiotensin-converting enzyme affinity, lowering angiotensin II and potentiating bradykinin. Efficacy, safety, and tolerability of perindopril are well established in the treatment of hypertension and heart failure. Moreover, large morbidity-mortality trials, such as the EUROPA, PROGRESS, and PREAMI have shown that treatment with perindopril reduces morbidity and mortality and prevents cardiovascular disease in a large range of patients with vascular diseases, whether or not they are hypertensive. Thus, the outcomes of these and other trials support the concept of cardiovascular protective properties of angiotensin-converting enzyme inhibition with perindopril in addition to the obvious blood-pressure-lowering effect. Considering its properties and the clinical evidence on efficacy and tolerability that has been gathered, perindopril should be considered a first-line therapeutic agent in hypertension, heart failure and acute myocardial infarction and a tool of secondary prevention of coronary artery disease.

Authors+Show Affiliations

Istituto di Cardiologia, Universittà degli Studi Policlinico S. Orsola-Malpighi, Bologna. crapezzi@orsola-malpighi.med.unibo.itNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
English Abstract
Journal Article
Review

Language

ita

PubMed ID

16485516

Citation

Rapezzi, Claudio, et al. "[Hypertension, Heart Failure, Myocardial Infarction, Secondary Prevention: the Role of Perindopril]." Italian Heart Journal : Official Journal of the Italian Federation of Cardiology, vol. 6 Suppl 7, 2005, 40S-47S.
Rapezzi C, Ciliberti P, Graziosi M, et al. [Hypertension, heart failure, myocardial infarction, secondary prevention: the role of perindopril]. Ital Heart J. 2005;6 Suppl 7:40S-47S.
Rapezzi, C., Ciliberti, P., Graziosi, M., & Riva, L. (2005). [Hypertension, heart failure, myocardial infarction, secondary prevention: the role of perindopril]. Italian Heart Journal : Official Journal of the Italian Federation of Cardiology, 6 Suppl 7, 40S-47S.
Rapezzi C, et al. [Hypertension, Heart Failure, Myocardial Infarction, Secondary Prevention: the Role of Perindopril]. Ital Heart J. 2005;6 Suppl 7:40S-47S. PubMed PMID: 16485516.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Hypertension, heart failure, myocardial infarction, secondary prevention: the role of perindopril]. AU - Rapezzi,Claudio, AU - Ciliberti,Paolo, AU - Graziosi,Maddalena, AU - Riva,Letizia, PY - 2006/2/21/pubmed PY - 2006/3/11/medline PY - 2006/2/21/entrez SP - 40S EP - 47S JF - Italian heart journal : official journal of the Italian Federation of Cardiology JO - Ital Heart J VL - 6 Suppl 7 N2 - Perindopril is a long-acting, once-daily lipophilic angiotensin-converting enzyme inhibitor with high tissue angiotensin-converting enzyme affinity, lowering angiotensin II and potentiating bradykinin. Efficacy, safety, and tolerability of perindopril are well established in the treatment of hypertension and heart failure. Moreover, large morbidity-mortality trials, such as the EUROPA, PROGRESS, and PREAMI have shown that treatment with perindopril reduces morbidity and mortality and prevents cardiovascular disease in a large range of patients with vascular diseases, whether or not they are hypertensive. Thus, the outcomes of these and other trials support the concept of cardiovascular protective properties of angiotensin-converting enzyme inhibition with perindopril in addition to the obvious blood-pressure-lowering effect. Considering its properties and the clinical evidence on efficacy and tolerability that has been gathered, perindopril should be considered a first-line therapeutic agent in hypertension, heart failure and acute myocardial infarction and a tool of secondary prevention of coronary artery disease. SN - 1129-471X UR - https://www.unboundmedicine.com/medline/citation/16485516/[Hypertension_heart_failure_myocardial_infarction_secondary_prevention:_the_role_of_perindopril]_ L2 - https://medlineplus.gov/heartattack.html DB - PRIME DP - Unbound Medicine ER -