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Tacalcitol and narrow-band phototherapy in patients with vitiligo.
Clin Exp Dermatol. 2006 Mar; 31(2):200-5.CE

Abstract

BACKGROUND

Vitiligo is a skin disease characterized by loss of normal pigmentation in the skin. Several treatments exist but none is really effective. Recently, perturbations of calcium homeostasis in vitiliginous epidermis have been described.

AIM

Based on these findings, the aim of this prospective, randomized, open-label study was to compare the effectiveness of narrow-band ultraviolet B (NB-UVB) phototherapy alone and the combination of NB-UVB and topical application of the vitamin D(3) analogue tacalcitol in the treatment of vitiligo.

METHODS

In total, 32 subjects with generalized vitiligo and symmetrical lesions were enrolled in the study. Subjects were instructed to apply tacalcitol ointment daily to the lesion on the side randomly selected to receive combination therapy. All subjects received NB-UVB phototherapy on a twice-weekly schedule.

RESULTS

Addition of topical tacalcitol to NB-UVB treatment improved the extent of repigmentation and increased the response rate in patients with vitiligo compared with NB-UVB treatment alone.

CONCLUSION

Application of tacalcitol ointment in combination with twice-weekly NB-UVB phototherapy is an effective alternative treatment for patients with generalized vitiligo.

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Authors+Show Affiliations

Leone G
Phototherapy Unit, S. Gallicano Dermatological Institute, IRCCS, Rome, Italy.
Pacifico A
No affiliation info available
Iacovelli P
No affiliation info available
Paro Vidolin A
No affiliation info available
Picardo M
No affiliation info available

MeSH

Administration, CutaneousAdolescentAdultCombined Modality TherapyDermatologic AgentsDihydroxycholecalciferolsFemaleHumansMaleMiddle AgedOintmentsProspective StudiesSkin PigmentationTreatment OutcomeUltraviolet TherapyVitiligo

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

16487090

Citation

Leone, G, et al. "Tacalcitol and Narrow-band Phototherapy in Patients With Vitiligo." Clinical and Experimental Dermatology, vol. 31, no. 2, 2006, pp. 200-5.
Leone G, Pacifico A, Iacovelli P, et al. Tacalcitol and narrow-band phototherapy in patients with vitiligo. Clin Exp Dermatol. 2006;31(2):200-5.
Leone, G., Pacifico, A., Iacovelli, P., Paro Vidolin, A., & Picardo, M. (2006). Tacalcitol and narrow-band phototherapy in patients with vitiligo. Clinical and Experimental Dermatology, 31(2), 200-5.
Leone G, et al. Tacalcitol and Narrow-band Phototherapy in Patients With Vitiligo. Clin Exp Dermatol. 2006;31(2):200-5. PubMed PMID: 16487090.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Tacalcitol and narrow-band phototherapy in patients with vitiligo. AU - Leone,G, AU - Pacifico,A, AU - Iacovelli,P, AU - Paro Vidolin,A, AU - Picardo,M, PY - 2006/2/21/pubmed PY - 2006/8/30/medline PY - 2006/2/21/entrez SP - 200 EP - 5 JF - Clinical and experimental dermatology JO - Clin Exp Dermatol VL - 31 IS - 2 N2 - BACKGROUND: Vitiligo is a skin disease characterized by loss of normal pigmentation in the skin. Several treatments exist but none is really effective. Recently, perturbations of calcium homeostasis in vitiliginous epidermis have been described. AIM: Based on these findings, the aim of this prospective, randomized, open-label study was to compare the effectiveness of narrow-band ultraviolet B (NB-UVB) phototherapy alone and the combination of NB-UVB and topical application of the vitamin D(3) analogue tacalcitol in the treatment of vitiligo. METHODS: In total, 32 subjects with generalized vitiligo and symmetrical lesions were enrolled in the study. Subjects were instructed to apply tacalcitol ointment daily to the lesion on the side randomly selected to receive combination therapy. All subjects received NB-UVB phototherapy on a twice-weekly schedule. RESULTS: Addition of topical tacalcitol to NB-UVB treatment improved the extent of repigmentation and increased the response rate in patients with vitiligo compared with NB-UVB treatment alone. CONCLUSION: Application of tacalcitol ointment in combination with twice-weekly NB-UVB phototherapy is an effective alternative treatment for patients with generalized vitiligo. SN - 0307-6938 UR - https://www.unboundmedicine.com/medline/citation/16487090/Tacalcitol_and_narrow_band_phototherapy_in_patients_with_vitiligo_ L2 - https://doi.org/10.1111/j.1365-2230.2005.02037.x DB - PRIME DP - Unbound Medicine ER -