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Inspiratory muscle training in patients with heart failure and inspiratory muscle weakness: a randomized trial.
J Am Coll Cardiol 2006; 47(4):757-63JACC

Abstract

OBJECTIVES

This study sought to evaluate the effects of inspiratory muscle training in inspiratory muscle strength, as well as in functional capacity, ventilatory responses to exercise, recovery oxygen uptake kinetics, and quality of life in patients with chronic heart failure (CHF) and inspiratory muscle weakness.

BACKGROUND

Patients with CHF may have reduced strength and endurance in inspiratory muscles, which may contribute to exercise intolerance and is associated with a poor prognosis.

METHODS

Thirty-two patients with CHF and weakness of inspiratory muscles (maximal inspiratory pressure [Pi(max)] <70% of predicted) were randomly assigned to a 12-week program of inspiratory muscle training (IMT, 16 patients) or to a placebo-inspiratory muscle training (P-IMT, 16 patients). The following measures were obtained before and after the program: Pi(max) at rest and 10 min after maximal exercise; peak oxygen uptake, circulatory power, ventilatory oscillations, and oxygen kinetics during early recovery (VO2/t-slope); 6-min walk test; and quality of life scores.

RESULTS

The IMT resulted in a 115% increment Pi(max), 17% increase in peak oxygen uptake, and 19% increase in the 6-min walk distance. Likewise, circulatory power increased and ventilatory oscillations were reduced. The VO2/t-slope was improved during the recovery period, and quality of life scores improved.

CONCLUSIONS

In patients with CHF and inspiratory muscle weakness, IMT results in marked improvement in inspiratory muscle strength, as well as improvement in functional capacity, ventilatory response to exercise, recovery oxygen uptake kinetics, and quality of life.

Authors+Show Affiliations

Department of Physiological Sciences, Fundação Faculdade Federal de Ciências Médicas de Porto Alegre, Porto Alegre, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16487841

Citation

Dall'Ago, Pedro, et al. "Inspiratory Muscle Training in Patients With Heart Failure and Inspiratory Muscle Weakness: a Randomized Trial." Journal of the American College of Cardiology, vol. 47, no. 4, 2006, pp. 757-63.
Dall'Ago P, Chiappa GR, Guths H, et al. Inspiratory muscle training in patients with heart failure and inspiratory muscle weakness: a randomized trial. J Am Coll Cardiol. 2006;47(4):757-63.
Dall'Ago, P., Chiappa, G. R., Guths, H., Stein, R., & Ribeiro, J. P. (2006). Inspiratory muscle training in patients with heart failure and inspiratory muscle weakness: a randomized trial. Journal of the American College of Cardiology, 47(4), pp. 757-63.
Dall'Ago P, et al. Inspiratory Muscle Training in Patients With Heart Failure and Inspiratory Muscle Weakness: a Randomized Trial. J Am Coll Cardiol. 2006 Feb 21;47(4):757-63. PubMed PMID: 16487841.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Inspiratory muscle training in patients with heart failure and inspiratory muscle weakness: a randomized trial. AU - Dall'Ago,Pedro, AU - Chiappa,Gaspar R S, AU - Guths,Henrique, AU - Stein,Ricardo, AU - Ribeiro,Jorge P, Y1 - 2006/01/26/ PY - 2005/05/24/received PY - 2005/08/21/revised PY - 2005/09/26/accepted PY - 2006/2/21/pubmed PY - 2006/4/29/medline PY - 2006/2/21/entrez SP - 757 EP - 63 JF - Journal of the American College of Cardiology JO - J. Am. Coll. Cardiol. VL - 47 IS - 4 N2 - OBJECTIVES: This study sought to evaluate the effects of inspiratory muscle training in inspiratory muscle strength, as well as in functional capacity, ventilatory responses to exercise, recovery oxygen uptake kinetics, and quality of life in patients with chronic heart failure (CHF) and inspiratory muscle weakness. BACKGROUND: Patients with CHF may have reduced strength and endurance in inspiratory muscles, which may contribute to exercise intolerance and is associated with a poor prognosis. METHODS: Thirty-two patients with CHF and weakness of inspiratory muscles (maximal inspiratory pressure [Pi(max)] <70% of predicted) were randomly assigned to a 12-week program of inspiratory muscle training (IMT, 16 patients) or to a placebo-inspiratory muscle training (P-IMT, 16 patients). The following measures were obtained before and after the program: Pi(max) at rest and 10 min after maximal exercise; peak oxygen uptake, circulatory power, ventilatory oscillations, and oxygen kinetics during early recovery (VO2/t-slope); 6-min walk test; and quality of life scores. RESULTS: The IMT resulted in a 115% increment Pi(max), 17% increase in peak oxygen uptake, and 19% increase in the 6-min walk distance. Likewise, circulatory power increased and ventilatory oscillations were reduced. The VO2/t-slope was improved during the recovery period, and quality of life scores improved. CONCLUSIONS: In patients with CHF and inspiratory muscle weakness, IMT results in marked improvement in inspiratory muscle strength, as well as improvement in functional capacity, ventilatory response to exercise, recovery oxygen uptake kinetics, and quality of life. SN - 1558-3597 UR - https://www.unboundmedicine.com/medline/citation/16487841/Inspiratory_muscle_training_in_patients_with_heart_failure_and_inspiratory_muscle_weakness:_a_randomized_trial_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0735-1097(05)02784-1 DB - PRIME DP - Unbound Medicine ER -