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Head and neck amyloidosis: a clinicopathologic study of 15 cases.
Oral Oncol. 2006 Apr; 42(4):421-9.OO

Abstract

Amyloidosis refers to the idiopathic, extracellular deposition of fibrillar proteins, termed amyloid, in tissues. Although amyloidosis is a rare disease, the head and neck region has been reported as a frequent site of amyloid deposits, accounting for approximately 19% of reported amyloid cases in one review. Fifteen cases of head and neck amyloid, excluding the brain, with clinical follow-up were identified in the Surgical Pathology files from 1985 to 2005 at Emory University Hospital. The histopathology, histochemistry, and patient follow-up were reviewed. Nine men and six women with an age range of 18-76 years (mean 55.7 years) were identified. The initial clinical presentation was dependent on the site of amyloid deposits. The clinical types of amyloidosis included localized amyloid deposits in the larynx and tongue, plasma cell dyscrasia associated AL amyloidosis, and hemodialysis-associated amyloidosis. Secondary amyloidosis developed in one patient with carcinoid tumor.

Authors+Show Affiliations

Department of Pathology, University of Manitoba, MS477D Thorlakson Building, 820 Sherbrook Street, Winnepeg, Manitoba, Canada R3A 1R9.No affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

16488655

Citation

Penner, Carla R., and Susan Muller. "Head and Neck Amyloidosis: a Clinicopathologic Study of 15 Cases." Oral Oncology, vol. 42, no. 4, 2006, pp. 421-9.
Penner CR, Muller S. Head and neck amyloidosis: a clinicopathologic study of 15 cases. Oral Oncol. 2006;42(4):421-9.
Penner, C. R., & Muller, S. (2006). Head and neck amyloidosis: a clinicopathologic study of 15 cases. Oral Oncology, 42(4), 421-9.
Penner CR, Muller S. Head and Neck Amyloidosis: a Clinicopathologic Study of 15 Cases. Oral Oncol. 2006;42(4):421-9. PubMed PMID: 16488655.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Head and neck amyloidosis: a clinicopathologic study of 15 cases. AU - Penner,Carla R, AU - Muller,Susan, Y1 - 2006/02/20/ PY - 2005/09/19/received PY - 2005/09/21/accepted PY - 2006/2/21/pubmed PY - 2006/12/12/medline PY - 2006/2/21/entrez SP - 421 EP - 9 JF - Oral oncology JO - Oral Oncol. VL - 42 IS - 4 N2 - Amyloidosis refers to the idiopathic, extracellular deposition of fibrillar proteins, termed amyloid, in tissues. Although amyloidosis is a rare disease, the head and neck region has been reported as a frequent site of amyloid deposits, accounting for approximately 19% of reported amyloid cases in one review. Fifteen cases of head and neck amyloid, excluding the brain, with clinical follow-up were identified in the Surgical Pathology files from 1985 to 2005 at Emory University Hospital. The histopathology, histochemistry, and patient follow-up were reviewed. Nine men and six women with an age range of 18-76 years (mean 55.7 years) were identified. The initial clinical presentation was dependent on the site of amyloid deposits. The clinical types of amyloidosis included localized amyloid deposits in the larynx and tongue, plasma cell dyscrasia associated AL amyloidosis, and hemodialysis-associated amyloidosis. Secondary amyloidosis developed in one patient with carcinoid tumor. SN - 1368-8375 UR - https://www.unboundmedicine.com/medline/citation/16488655/Head_and_neck_amyloidosis:_a_clinicopathologic_study_of_15_cases_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1368-8375(05)00278-2 DB - PRIME DP - Unbound Medicine ER -