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Characteristics of left ventricular diastolic dysfunction in the community: an echocardiographic survey.
Heart 2006; 92(9):1259-64H

Abstract

OBJECTIVE

To determine the prevalence and predictors of left ventricular (LV) diastolic dysfunction in older adults.

DESIGN, SETTING AND PARTICIPANTS

A cross-sectional survey of 1275 randomly selected residents of Canberra, aged 60 to 86 years (mean age 69.4; 50% men), conducted between February 2002 and June 2003.

MAIN OUTCOME MEASURES

Prevalence of LV diastolic dysfunction as characterised by comprehensive Doppler echocardiography.

RESULTS

The prevalence of any diastolic dysfunction was 34.7% (95% CI 32.1% to 37.4%) and that of moderate to severe diastolic dysfunction was 7.3% (95% CI 5.9% to 8.9%). Of subjects with moderate to severe diastolic dysfunction, 77.4% had an LV ejection fraction (EF) > 50% and 76.3% were in a preclinical stage of disease. Predictors of diastolic dysfunction were higher age (p < 0.0001), reduced EF (p < 0.0001), obesity (p < 0.0001) and a history of hypertension (p < 0.0001), diabetes (p = 0.02) and myocardial infarction (p = 0.003). Moderate to severe diastolic dysfunction with normal EF, although predominantly preclinical, was independently associated with increased LV mass (p < 0.0001), left atrial volume (p < 0.0001), and circulating amino-terminal pro-B-type natriuretic peptide concentrations (p < 0.0001), and with decreased quality of life (p < 0.005).

CONCLUSION

Diastolic dysfunction is common in the community and often unaccompanied by overt congestive heart failure. Despite the lack of symptoms, advanced diastolic dysfunction with normal EF is associated with reduced quality of life and structural abnormalities that reflect increased cardiovascular risk.

Authors+Show Affiliations

National Centre for Epidemiology and Population Health, Australian National University and Department of Cardiology, The Canberra Hospital, Canberra, ACT, Australia. abhayaratna.walter@mayo.eduNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16488928

Citation

Abhayaratna, W P., et al. "Characteristics of Left Ventricular Diastolic Dysfunction in the Community: an Echocardiographic Survey." Heart (British Cardiac Society), vol. 92, no. 9, 2006, pp. 1259-64.
Abhayaratna WP, Marwick TH, Smith WT, et al. Characteristics of left ventricular diastolic dysfunction in the community: an echocardiographic survey. Heart. 2006;92(9):1259-64.
Abhayaratna, W. P., Marwick, T. H., Smith, W. T., & Becker, N. G. (2006). Characteristics of left ventricular diastolic dysfunction in the community: an echocardiographic survey. Heart (British Cardiac Society), 92(9), pp. 1259-64.
Abhayaratna WP, et al. Characteristics of Left Ventricular Diastolic Dysfunction in the Community: an Echocardiographic Survey. Heart. 2006;92(9):1259-64. PubMed PMID: 16488928.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Characteristics of left ventricular diastolic dysfunction in the community: an echocardiographic survey. AU - Abhayaratna,W P, AU - Marwick,T H, AU - Smith,W T, AU - Becker,N G, Y1 - 2006/02/17/ PY - 2006/2/21/pubmed PY - 2006/9/13/medline PY - 2006/2/21/entrez SP - 1259 EP - 64 JF - Heart (British Cardiac Society) JO - Heart VL - 92 IS - 9 N2 - OBJECTIVE: To determine the prevalence and predictors of left ventricular (LV) diastolic dysfunction in older adults. DESIGN, SETTING AND PARTICIPANTS: A cross-sectional survey of 1275 randomly selected residents of Canberra, aged 60 to 86 years (mean age 69.4; 50% men), conducted between February 2002 and June 2003. MAIN OUTCOME MEASURES: Prevalence of LV diastolic dysfunction as characterised by comprehensive Doppler echocardiography. RESULTS: The prevalence of any diastolic dysfunction was 34.7% (95% CI 32.1% to 37.4%) and that of moderate to severe diastolic dysfunction was 7.3% (95% CI 5.9% to 8.9%). Of subjects with moderate to severe diastolic dysfunction, 77.4% had an LV ejection fraction (EF) > 50% and 76.3% were in a preclinical stage of disease. Predictors of diastolic dysfunction were higher age (p < 0.0001), reduced EF (p < 0.0001), obesity (p < 0.0001) and a history of hypertension (p < 0.0001), diabetes (p = 0.02) and myocardial infarction (p = 0.003). Moderate to severe diastolic dysfunction with normal EF, although predominantly preclinical, was independently associated with increased LV mass (p < 0.0001), left atrial volume (p < 0.0001), and circulating amino-terminal pro-B-type natriuretic peptide concentrations (p < 0.0001), and with decreased quality of life (p < 0.005). CONCLUSION: Diastolic dysfunction is common in the community and often unaccompanied by overt congestive heart failure. Despite the lack of symptoms, advanced diastolic dysfunction with normal EF is associated with reduced quality of life and structural abnormalities that reflect increased cardiovascular risk. SN - 1468-201X UR - https://www.unboundmedicine.com/medline/citation/16488928/Characteristics_of_left_ventricular_diastolic_dysfunction_in_the_community:_an_echocardiographic_survey_ L2 - http://heart.bmj.com/cgi/pmidlookup?view=long&amp;pmid=16488928 DB - PRIME DP - Unbound Medicine ER -