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Oxidative stress in patients with acne vulgaris.
Mediators Inflamm. 2005 Dec 14; 2005(6):380-4.MI

Abstract

Acne vulgaris is one of the common dermatological diseases and its pathogenesis is multifactorial. In this study, we aim to determine the effects of oxidative stress in acne vulgaris. Forty-three consecutive acne patients and 46 controls were enrolled. The parameters of oxidative stress such as catalase (CAT), glucose-6-phosphate dehydrogenase (G6PD), superoxide dismutase (SOD), and malondialdehyde (MDA) in the venous blood of cases were measured spectrophotometrically. The values compared with control group, the relation between the severity and distribution of acne, and the correlation of each enzyme level were researched. CAT and G6PD levels in patients were found to be statistically decreased, and SOD and MDA levels were found to be statistically increased (P < .001). However, any statistical difference and correlation could not be found between the severity and distribution of lesions and the mean levels of enzymes. In addition, we found that each enzyme is correlated with one another. Our findings show that oxidative stress exists in the acne patients. It will be useful to apply at least one antioxidant featured drug along with the combined acne treatment.

Authors+Show Affiliations

Department of Dermatology, Kahramanmaras Sutcuimam Medical Faculty, Turkey. ozerari@gmail.comNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16489259

Citation

Arican, Ozer, et al. "Oxidative Stress in Patients With Acne Vulgaris." Mediators of Inflammation, vol. 2005, no. 6, 2005, pp. 380-4.
Arican O, Kurutas EB, Sasmaz S. Oxidative stress in patients with acne vulgaris. Mediators Inflamm. 2005;2005(6):380-4.
Arican, O., Kurutas, E. B., & Sasmaz, S. (2005). Oxidative stress in patients with acne vulgaris. Mediators of Inflammation, 2005(6), 380-4.
Arican O, Kurutas EB, Sasmaz S. Oxidative Stress in Patients With Acne Vulgaris. Mediators Inflamm. 2005 Dec 14;2005(6):380-4. PubMed PMID: 16489259.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Oxidative stress in patients with acne vulgaris. AU - Arican,Ozer, AU - Kurutas,Ergul Belge, AU - Sasmaz,Sezai, PY - 2006/2/21/pubmed PY - 2006/12/28/medline PY - 2006/2/21/entrez SP - 380 EP - 4 JF - Mediators of inflammation JO - Mediators Inflamm VL - 2005 IS - 6 N2 - Acne vulgaris is one of the common dermatological diseases and its pathogenesis is multifactorial. In this study, we aim to determine the effects of oxidative stress in acne vulgaris. Forty-three consecutive acne patients and 46 controls were enrolled. The parameters of oxidative stress such as catalase (CAT), glucose-6-phosphate dehydrogenase (G6PD), superoxide dismutase (SOD), and malondialdehyde (MDA) in the venous blood of cases were measured spectrophotometrically. The values compared with control group, the relation between the severity and distribution of acne, and the correlation of each enzyme level were researched. CAT and G6PD levels in patients were found to be statistically decreased, and SOD and MDA levels were found to be statistically increased (P < .001). However, any statistical difference and correlation could not be found between the severity and distribution of lesions and the mean levels of enzymes. In addition, we found that each enzyme is correlated with one another. Our findings show that oxidative stress exists in the acne patients. It will be useful to apply at least one antioxidant featured drug along with the combined acne treatment. SN - 0962-9351 UR - https://www.unboundmedicine.com/medline/citation/16489259/Oxidative_stress_in_patients_with_acne_vulgaris_ L2 - https://doi.org/10.1155/MI.2005.380 DB - PRIME DP - Unbound Medicine ER -