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Random number generation during sleep deprivation: effects of caffeine on response maintenance and stereotypy.
J Sleep Res. 2006 Mar; 15(1):31-40.JS

Abstract

Neurophysiological and functional imaging studies have demonstrated that frontal regions of the brain are particularly responsive to homeostatic sleep pressure. Previous neuropsychological studies indicate that sleep deprivation causes impairments in prefrontal cortical function. Random number generation (RNG) is thought to provide a sensitive index of executive functions that rely on the prefrontal cortex. The present study tested the hypothesis that sleep deprivation would impair RNG and that caffeine would mitigate this impairment. Healthy young men (n = 21) participated in two 40-h sleep deprivations 1 week apart. During each sleep deprivation period subjects received either caffeine or placebo according to a randomized, double-blind cross-over design, and they completed an oral RNG task at 3-h intervals. Comparison of test sessions at analogous times of day revealed that sleep deprivation was associated with significant drops in the number of responses, a threefold increase in the percentage of rule violations, 59% greater response redundancy and a 20% increase in stereotypy of adjacent response pairs. Sleep deprivation did not consistently alter counting tendency. Caffeine ameliorated the decrease in the number of responses but did not mitigate other deficits in RNG that arose during sleep deprivation. These findings are consistent with prior reports of diminished vigilance and increased perseveration during extended wakefulness. They support the conclusion that caffeine preserves simple aspects of cognitive performance during sleep deprivation, whereas caffeine may not prevent detrimental effects of sleep deprivation on some complex cognitive functions.

Authors+Show Affiliations

Section of Psychopharmacology and Sleep Research, Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland. jgottselig@rics.bwh.harvard.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16490000

Citation

Gottselig, Julie M., et al. "Random Number Generation During Sleep Deprivation: Effects of Caffeine On Response Maintenance and Stereotypy." Journal of Sleep Research, vol. 15, no. 1, 2006, pp. 31-40.
Gottselig JM, Adam M, Rétey JV, et al. Random number generation during sleep deprivation: effects of caffeine on response maintenance and stereotypy. J Sleep Res. 2006;15(1):31-40.
Gottselig, J. M., Adam, M., Rétey, J. V., Khatami, R., Achermann, P., & Landolt, H. P. (2006). Random number generation during sleep deprivation: effects of caffeine on response maintenance and stereotypy. Journal of Sleep Research, 15(1), 31-40.
Gottselig JM, et al. Random Number Generation During Sleep Deprivation: Effects of Caffeine On Response Maintenance and Stereotypy. J Sleep Res. 2006;15(1):31-40. PubMed PMID: 16490000.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Random number generation during sleep deprivation: effects of caffeine on response maintenance and stereotypy. AU - Gottselig,Julie M, AU - Adam,Martin, AU - Rétey,Julia V, AU - Khatami,Ramin, AU - Achermann,Peter, AU - Landolt,Hans-Peter, PY - 2006/2/24/pubmed PY - 2006/7/13/medline PY - 2006/2/24/entrez SP - 31 EP - 40 JF - Journal of sleep research JO - J Sleep Res VL - 15 IS - 1 N2 - Neurophysiological and functional imaging studies have demonstrated that frontal regions of the brain are particularly responsive to homeostatic sleep pressure. Previous neuropsychological studies indicate that sleep deprivation causes impairments in prefrontal cortical function. Random number generation (RNG) is thought to provide a sensitive index of executive functions that rely on the prefrontal cortex. The present study tested the hypothesis that sleep deprivation would impair RNG and that caffeine would mitigate this impairment. Healthy young men (n = 21) participated in two 40-h sleep deprivations 1 week apart. During each sleep deprivation period subjects received either caffeine or placebo according to a randomized, double-blind cross-over design, and they completed an oral RNG task at 3-h intervals. Comparison of test sessions at analogous times of day revealed that sleep deprivation was associated with significant drops in the number of responses, a threefold increase in the percentage of rule violations, 59% greater response redundancy and a 20% increase in stereotypy of adjacent response pairs. Sleep deprivation did not consistently alter counting tendency. Caffeine ameliorated the decrease in the number of responses but did not mitigate other deficits in RNG that arose during sleep deprivation. These findings are consistent with prior reports of diminished vigilance and increased perseveration during extended wakefulness. They support the conclusion that caffeine preserves simple aspects of cognitive performance during sleep deprivation, whereas caffeine may not prevent detrimental effects of sleep deprivation on some complex cognitive functions. SN - 0962-1105 UR - https://www.unboundmedicine.com/medline/citation/16490000/Random_number_generation_during_sleep_deprivation:_effects_of_caffeine_on_response_maintenance_and_stereotypy_ L2 - https://doi.org/10.1111/j.1365-2869.2006.00497.x DB - PRIME DP - Unbound Medicine ER -