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Intraepidermal nerve fibre density, quantitative sensory testing and nerve conduction studies in a patient material with symptoms and signs of sensory polyneuropathy.
Eur J Neurol. 2006 Feb; 13(2):105-11.EJ

Abstract

Small diameter nerve fibre (SDNF) neuropathy is an axonal sensory neuropathy affecting unmyelinated (C) and thin myelinated (A-delta) fibres. We have evaluated 75 patients with symptoms and signs suggesting SDNF dysfunction with or without symptoms and signs of co-existing large diameter nerve fibre involvement. The patients were examined clinically and underwent skin biopsy, quantitative sensory testing (QST) and nerve conduction studies (NCS). The purpose of this study was to compare the relationship between the different methods and in particular measurements of thermal thresholds and intraepidermal nerve fibre (IENF) density in the same site of the distal leg. The main subdivision of the patient material was made according to the overall NCS pattern. Patients with normal NCS (38) had 6.4 +/- 3.8 and patients with abnormal NCS (37) had 4.4 +/- 3.4 IENF per mm (P = 0.02). Limen (difference between warm and cold perception thresholds) was significantly higher (more abnormal) in those with abnormal than in those with normal NCS (22.1 +/- 9.1 vs. 13.4 +/- 5.6, P < 0.0001). Cold perception threshold was more abnormal (P < 0.0001) than warm perception threshold (P = 0.002). Correlation between IENF and QST was statistically significant only when NCS was abnormal, and thus dependent of a more severe neuropathic process in SDNFs.

Authors+Show Affiliations

Department of Neurology, University Hospital of North Norway, Tromsø, Norway. sissel.loseth@unn.noNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16490039

Citation

Løseth, S, et al. "Intraepidermal Nerve Fibre Density, Quantitative Sensory Testing and Nerve Conduction Studies in a Patient Material With Symptoms and Signs of Sensory Polyneuropathy." European Journal of Neurology, vol. 13, no. 2, 2006, pp. 105-11.
Løseth S, Lindal S, Stålberg E, et al. Intraepidermal nerve fibre density, quantitative sensory testing and nerve conduction studies in a patient material with symptoms and signs of sensory polyneuropathy. Eur J Neurol. 2006;13(2):105-11.
Løseth, S., Lindal, S., Stålberg, E., & Mellgren, S. I. (2006). Intraepidermal nerve fibre density, quantitative sensory testing and nerve conduction studies in a patient material with symptoms and signs of sensory polyneuropathy. European Journal of Neurology, 13(2), 105-11.
Løseth S, et al. Intraepidermal Nerve Fibre Density, Quantitative Sensory Testing and Nerve Conduction Studies in a Patient Material With Symptoms and Signs of Sensory Polyneuropathy. Eur J Neurol. 2006;13(2):105-11. PubMed PMID: 16490039.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Intraepidermal nerve fibre density, quantitative sensory testing and nerve conduction studies in a patient material with symptoms and signs of sensory polyneuropathy. AU - Løseth,S, AU - Lindal,S, AU - Stålberg,E, AU - Mellgren,S I, PY - 2006/2/24/pubmed PY - 2006/5/10/medline PY - 2006/2/24/entrez SP - 105 EP - 11 JF - European journal of neurology JO - Eur J Neurol VL - 13 IS - 2 N2 - Small diameter nerve fibre (SDNF) neuropathy is an axonal sensory neuropathy affecting unmyelinated (C) and thin myelinated (A-delta) fibres. We have evaluated 75 patients with symptoms and signs suggesting SDNF dysfunction with or without symptoms and signs of co-existing large diameter nerve fibre involvement. The patients were examined clinically and underwent skin biopsy, quantitative sensory testing (QST) and nerve conduction studies (NCS). The purpose of this study was to compare the relationship between the different methods and in particular measurements of thermal thresholds and intraepidermal nerve fibre (IENF) density in the same site of the distal leg. The main subdivision of the patient material was made according to the overall NCS pattern. Patients with normal NCS (38) had 6.4 +/- 3.8 and patients with abnormal NCS (37) had 4.4 +/- 3.4 IENF per mm (P = 0.02). Limen (difference between warm and cold perception thresholds) was significantly higher (more abnormal) in those with abnormal than in those with normal NCS (22.1 +/- 9.1 vs. 13.4 +/- 5.6, P < 0.0001). Cold perception threshold was more abnormal (P < 0.0001) than warm perception threshold (P = 0.002). Correlation between IENF and QST was statistically significant only when NCS was abnormal, and thus dependent of a more severe neuropathic process in SDNFs. SN - 1351-5101 UR - https://www.unboundmedicine.com/medline/citation/16490039/Intraepidermal_nerve_fibre_density_quantitative_sensory_testing_and_nerve_conduction_studies_in_a_patient_material_with_symptoms_and_signs_of_sensory_polyneuropathy_ L2 - https://doi.org/10.1111/j.1468-1331.2006.01232.x DB - PRIME DP - Unbound Medicine ER -