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Cytomegalovirus in aqueous humor from an eye with corneal endotheliitis.
Am J Ophthalmol. 2006 Mar; 141(3):564-5.AJ

Abstract

PURPOSE

To report cytomegalovirus (CMV) DNA in aqueous humor from a patient with unilateral corneal endotheliitis.

DESIGN

Case report.

METHODS

A 51-year-old man presented with unilateral corneal endotheliitis with linear keratic precipitates and coin-shaped lesions. Tear and aqueous humor samples were subjected to polymerase chain reaction to look for DNA from herpes simplex virus (HSV), varicella zoster virus (VZV), and CMV.

RESULTS

Aqueous humor from the diseased eye contained DNA from CMV but not HSV or VZV. Its specificity was confirmed by Southern blot tests. Intravenous ganciclovir treatment resulted in the localization of his corneal edema and the reduction in keratic precipitates. There was severe destruction of corneal endothelial cells. CMV DNA was not detected in tears or control samples.

CONCLUSIONS

In this healthy man with corneal endotheliitis, we detected CMV DNA in aqueous humor from the affected eye, but not HSV or VZV. This suggests that CMV may cause corneal endotheliitis in patients without immunodeficiency.

Authors+Show Affiliations

Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kawaramachi Hirokoji, Kamigyo-ku, Kyoto 602-0841, Japan. nkoizumi@ophth.kpu-m.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16490509

Citation

Koizumi, Noriko, et al. "Cytomegalovirus in Aqueous Humor From an Eye With Corneal Endotheliitis." American Journal of Ophthalmology, vol. 141, no. 3, 2006, pp. 564-5.
Koizumi N, Yamasaki K, Kawasaki S, et al. Cytomegalovirus in aqueous humor from an eye with corneal endotheliitis. Am J Ophthalmol. 2006;141(3):564-5.
Koizumi, N., Yamasaki, K., Kawasaki, S., Sotozono, C., Inatomi, T., Mochida, C., & Kinoshita, S. (2006). Cytomegalovirus in aqueous humor from an eye with corneal endotheliitis. American Journal of Ophthalmology, 141(3), 564-5.
Koizumi N, et al. Cytomegalovirus in Aqueous Humor From an Eye With Corneal Endotheliitis. Am J Ophthalmol. 2006;141(3):564-5. PubMed PMID: 16490509.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cytomegalovirus in aqueous humor from an eye with corneal endotheliitis. AU - Koizumi,Noriko, AU - Yamasaki,Kenta, AU - Kawasaki,Satoshi, AU - Sotozono,Chie, AU - Inatomi,Tsutomu, AU - Mochida,Chikako, AU - Kinoshita,Shigeru, PY - 2005/08/08/received PY - 2005/09/15/revised PY - 2005/09/19/accepted PY - 2006/2/24/pubmed PY - 2006/3/28/medline PY - 2006/2/24/entrez SP - 564 EP - 5 JF - American journal of ophthalmology JO - Am. J. Ophthalmol. VL - 141 IS - 3 N2 - PURPOSE: To report cytomegalovirus (CMV) DNA in aqueous humor from a patient with unilateral corneal endotheliitis. DESIGN: Case report. METHODS: A 51-year-old man presented with unilateral corneal endotheliitis with linear keratic precipitates and coin-shaped lesions. Tear and aqueous humor samples were subjected to polymerase chain reaction to look for DNA from herpes simplex virus (HSV), varicella zoster virus (VZV), and CMV. RESULTS: Aqueous humor from the diseased eye contained DNA from CMV but not HSV or VZV. Its specificity was confirmed by Southern blot tests. Intravenous ganciclovir treatment resulted in the localization of his corneal edema and the reduction in keratic precipitates. There was severe destruction of corneal endothelial cells. CMV DNA was not detected in tears or control samples. CONCLUSIONS: In this healthy man with corneal endotheliitis, we detected CMV DNA in aqueous humor from the affected eye, but not HSV or VZV. This suggests that CMV may cause corneal endotheliitis in patients without immunodeficiency. SN - 0002-9394 UR - https://www.unboundmedicine.com/medline/citation/16490509/Cytomegalovirus_in_aqueous_humor_from_an_eye_with_corneal_endotheliitis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002-9394(05)01030-5 DB - PRIME DP - Unbound Medicine ER -