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Eremophilane sesquiterpenes from Ligularia myriocephala.
Planta Med. 2006 Feb; 72(2):175-9.PM

Abstract

Five new eremophilenolides, 1beta-angeloyloxy-6beta,10beta-dihydroxy-8beta-methoxyeremophil-7(11)-en-8alpha,12-olide (1), 1beta-angeloyloxy-6beta,10alpha-dihydroxy-8alpha-methoxyeremophil-7(11)-en-8beta,12-olide (2), 1beta,6beta-diangeloyloxy-8beta,10beta-dihydroxyeremophil-(11)-en-8alpha,12-olide (3), 1beta,6beta-diangeloyloxy-8alpha,10 alpha-dihydroxyeremophil-7(11)-en-8beta,12-olide (4), 1beta-angeloyloxy-8-oxoeremophil-6,9-dien-12-oic acid methyl ester (5) and one known compound, 8beta,10beta-dihydroxyeremophilenolide (6) were isolated from the extract of the whole plant of Ligularia myriocephala Ling. Their structures and stereochemistry were elucidated by various spectroscopic methods including intensive 2D-NMR techniques (COSY, gHMQC, gHMBC and (1)H- (1)H NOESY) and HR-ESI-MS. A single-crystal X-ray experiment was performed for compound 1.

Authors+Show Affiliations

Liu JX
Key Laboratory for Natural Medicine of the Gansu Province, Lanzhou Institute of Chemical Physics, Graduate School of the Chinese Academy of Sciences, Chinese Academy of Sciences, Lanzhou 730000, P. R. China.
Wei XN
No affiliation info available
Shi YP
No affiliation info available

MeSH

AsteraceaeCrystallography, X-RayMolecular ConformationNuclear Magnetic Resonance, BiomolecularPlant ExtractsSesquiterpenesTriterpenes

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16491455

Citation

Liu, Jun-Xi, et al. "Eremophilane Sesquiterpenes From Ligularia Myriocephala." Planta Medica, vol. 72, no. 2, 2006, pp. 175-9.
Liu JX, Wei XN, Shi YP. Eremophilane sesquiterpenes from Ligularia myriocephala. Planta Med. 2006;72(2):175-9.
Liu, J. X., Wei, X. N., & Shi, Y. P. (2006). Eremophilane sesquiterpenes from Ligularia myriocephala. Planta Medica, 72(2), 175-9.
Liu JX, Wei XN, Shi YP. Eremophilane Sesquiterpenes From Ligularia Myriocephala. Planta Med. 2006;72(2):175-9. PubMed PMID: 16491455.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Eremophilane sesquiterpenes from Ligularia myriocephala. AU - Liu,Jun-Xi, AU - Wei,Xiao-Ning, AU - Shi,Yan-Ping, PY - 2006/2/24/pubmed PY - 2006/4/20/medline PY - 2006/2/24/entrez SP - 175 EP - 9 JF - Planta medica JO - Planta Med VL - 72 IS - 2 N2 - Five new eremophilenolides, 1beta-angeloyloxy-6beta,10beta-dihydroxy-8beta-methoxyeremophil-7(11)-en-8alpha,12-olide (1), 1beta-angeloyloxy-6beta,10alpha-dihydroxy-8alpha-methoxyeremophil-7(11)-en-8beta,12-olide (2), 1beta,6beta-diangeloyloxy-8beta,10beta-dihydroxyeremophil-(11)-en-8alpha,12-olide (3), 1beta,6beta-diangeloyloxy-8alpha,10 alpha-dihydroxyeremophil-7(11)-en-8beta,12-olide (4), 1beta-angeloyloxy-8-oxoeremophil-6,9-dien-12-oic acid methyl ester (5) and one known compound, 8beta,10beta-dihydroxyeremophilenolide (6) were isolated from the extract of the whole plant of Ligularia myriocephala Ling. Their structures and stereochemistry were elucidated by various spectroscopic methods including intensive 2D-NMR techniques (COSY, gHMQC, gHMBC and (1)H- (1)H NOESY) and HR-ESI-MS. A single-crystal X-ray experiment was performed for compound 1. SN - 0032-0943 UR - https://www.unboundmedicine.com/medline/citation/16491455/Eremophilane_sesquiterpenes_from_Ligularia_myriocephala_ DB - PRIME DP - Unbound Medicine ER -