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Anti-trichomonal, biochemical and toxicological activities of methanolic extract and some carbazole alkaloids isolated from the leaves of Murraya koenigii growing in Nigeria.
Phytomedicine. 2006 Mar; 13(4):246-54.P

Abstract

The methanolic extract of Murraya koenigii leaf was screened for toxicological and biochemical effects on rats because of the folkloric uses as an anti-dysentery and anti-diabetes. The extract was moderately toxic (LD(50)=316.23 mg/kg body weight) to rats and had appreciable effect on the liver and kidney at higher doses leading to liver inflammation. It had little or no effect on haematology and relative organ weight of lungs, heart and spleen. Acute doses (500 mg/kg) reduced significantly serum globulin, albumin, urea, glucose, total protein, aspartate transaminase (AST), and increased cholesterol and alanine transaminase (ALT) indicating hepatic injury. However, chronic administration for 14 days gave a significant (p<0.05) reduction in the serum cholesterol, glucose, urea, bilirubin, ALT and AST showing that the plant has hypoglycaemic and hepatoprotective effects after prolonged use. The activity demonstrated by some of the isolated carbazole alkaloids and their derivatives against Trichomonas gallinae confirmed that the anti-trichomonal activity of the leaf may be due to its carbazole alkaloids. The order of activity was C(18)>C(23)>C(13). Girinimbine and girinimbilol with IC(50) values of 1.08 and 1.20 microg/ml were the most active. Acetylation of girinimbilol and mahanimbilol improved their activities to 0.60 and 1.08 microg/ml.

Authors+Show Affiliations

Department of Pharmacognosy, Faculty of Pharmacy, Obafemi Awolowo University, Ile-Ife, Nigeria. caadebajo@yahoo.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

16492527

Citation

Adebajo, A C., et al. "Anti-trichomonal, Biochemical and Toxicological Activities of Methanolic Extract and some Carbazole Alkaloids Isolated From the Leaves of Murraya Koenigii Growing in Nigeria." Phytomedicine : International Journal of Phytotherapy and Phytopharmacology, vol. 13, no. 4, 2006, pp. 246-54.
Adebajo AC, Ayoola OF, Iwalewa EO, et al. Anti-trichomonal, biochemical and toxicological activities of methanolic extract and some carbazole alkaloids isolated from the leaves of Murraya koenigii growing in Nigeria. Phytomedicine. 2006;13(4):246-54.
Adebajo, A. C., Ayoola, O. F., Iwalewa, E. O., Akindahunsi, A. A., Omisore, N. O., Adewunmi, C. O., & Adenowo, T. K. (2006). Anti-trichomonal, biochemical and toxicological activities of methanolic extract and some carbazole alkaloids isolated from the leaves of Murraya koenigii growing in Nigeria. Phytomedicine : International Journal of Phytotherapy and Phytopharmacology, 13(4), 246-54.
Adebajo AC, et al. Anti-trichomonal, Biochemical and Toxicological Activities of Methanolic Extract and some Carbazole Alkaloids Isolated From the Leaves of Murraya Koenigii Growing in Nigeria. Phytomedicine. 2006;13(4):246-54. PubMed PMID: 16492527.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anti-trichomonal, biochemical and toxicological activities of methanolic extract and some carbazole alkaloids isolated from the leaves of Murraya koenigii growing in Nigeria. AU - Adebajo,A C, AU - Ayoola,O F, AU - Iwalewa,E O, AU - Akindahunsi,A A, AU - Omisore,N O A, AU - Adewunmi,C O, AU - Adenowo,T K, Y1 - 2005/09/19/ PY - 2004/11/23/received PY - 2004/12/27/accepted PY - 2006/2/24/pubmed PY - 2006/5/10/medline PY - 2006/2/24/entrez SP - 246 EP - 54 JF - Phytomedicine : international journal of phytotherapy and phytopharmacology JO - Phytomedicine VL - 13 IS - 4 N2 - The methanolic extract of Murraya koenigii leaf was screened for toxicological and biochemical effects on rats because of the folkloric uses as an anti-dysentery and anti-diabetes. The extract was moderately toxic (LD(50)=316.23 mg/kg body weight) to rats and had appreciable effect on the liver and kidney at higher doses leading to liver inflammation. It had little or no effect on haematology and relative organ weight of lungs, heart and spleen. Acute doses (500 mg/kg) reduced significantly serum globulin, albumin, urea, glucose, total protein, aspartate transaminase (AST), and increased cholesterol and alanine transaminase (ALT) indicating hepatic injury. However, chronic administration for 14 days gave a significant (p<0.05) reduction in the serum cholesterol, glucose, urea, bilirubin, ALT and AST showing that the plant has hypoglycaemic and hepatoprotective effects after prolonged use. The activity demonstrated by some of the isolated carbazole alkaloids and their derivatives against Trichomonas gallinae confirmed that the anti-trichomonal activity of the leaf may be due to its carbazole alkaloids. The order of activity was C(18)>C(23)>C(13). Girinimbine and girinimbilol with IC(50) values of 1.08 and 1.20 microg/ml were the most active. Acetylation of girinimbilol and mahanimbilol improved their activities to 0.60 and 1.08 microg/ml. SN - 0944-7113 UR - https://www.unboundmedicine.com/medline/citation/16492527/Anti_trichomonal_biochemical_and_toxicological_activities_of_methanolic_extract_and_some_carbazole_alkaloids_isolated_from_the_leaves_of_Murraya_koenigii_growing_in_Nigeria_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0944-7113(05)00155-8 DB - PRIME DP - Unbound Medicine ER -