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Dairy products and ovarian cancer: a pooled analysis of 12 cohort studies.

Abstract

BACKGROUND

Dairy foods and their constituents (lactose and calcium) have been hypothesized to promote ovarian carcinogenesis. Although case-control studies have reported conflicting results for dairy foods and lactose, several cohort studies have shown positive associations between skim milk, lactose, and ovarian cancer.

METHODS

A pooled analysis of the primary data from 12 prospective cohort studies was conducted. The study population consisted of 553,217 women among whom 2,132 epithelial ovarian cases were identified. Study-specific relative risks and 95% confidence intervals were calculated by Cox proportional hazards models and then pooled by a random-effects model.

RESULTS

No statistically significant associations were observed between intakes of milk, cheese, yogurt, ice cream, and dietary and total calcium intake and risk of ovarian cancer. Higher lactose intakes comparing > or = 30 versus <10 g/d were associated with a statistically significant higher risk of ovarian cancer, although the trend was not statistically significant (pooled multivariate relative risk, 1.19; 95% confidence interval, 1.01-1.40; P(trend) = 0.19). Associations for endometrioid, mucinous, and serous ovarian cancer were similar to the overall findings.

DISCUSSION

Overall, no associations were observed for intakes of specific dairy foods or calcium and ovarian cancer risk. A modest elevation in the risk of ovarian cancer was seen for lactose intake at the level that was equivalent to three or more servings of milk per day. Because a new dietary guideline recommends two to three servings of dairy products per day, the relation between dairy product consumption and ovarian cancer risk at these consumption levels deserves further examination.

Authors+Show Affiliations

Department of Nutrition, Harvard School of Public Health, Room 339, Building 2, 665 Huntington Avenue, Boston, Massachusetts 02115, USA. pooling@hsphsun2.harvard.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

16492930

Citation

Genkinger, Jeanine M., et al. "Dairy Products and Ovarian Cancer: a Pooled Analysis of 12 Cohort Studies." Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, vol. 15, no. 2, 2006, pp. 364-72.
Genkinger JM, Hunter DJ, Spiegelman D, et al. Dairy products and ovarian cancer: a pooled analysis of 12 cohort studies. Cancer Epidemiol Biomarkers Prev. 2006;15(2):364-72.
Genkinger, J. M., Hunter, D. J., Spiegelman, D., Anderson, K. E., Arslan, A., Beeson, W. L., ... Smith-Warner, S. A. (2006). Dairy products and ovarian cancer: a pooled analysis of 12 cohort studies. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, 15(2), pp. 364-72.
Genkinger JM, et al. Dairy Products and Ovarian Cancer: a Pooled Analysis of 12 Cohort Studies. Cancer Epidemiol Biomarkers Prev. 2006;15(2):364-72. PubMed PMID: 16492930.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dairy products and ovarian cancer: a pooled analysis of 12 cohort studies. AU - Genkinger,Jeanine M, AU - Hunter,David J, AU - Spiegelman,Donna, AU - Anderson,Kristin E, AU - Arslan,Alan, AU - Beeson,W Lawrence, AU - Buring,Julie E, AU - Fraser,Gary E, AU - Freudenheim,Jo L, AU - Goldbohm,R Alexandra, AU - Hankinson,Susan E, AU - Jacobs,David R,Jr AU - Koushik,Anita, AU - Lacey,James V,Jr AU - Larsson,Susanna C, AU - Leitzmann,Michael, AU - McCullough,Marji L, AU - Miller,Anthony B, AU - Rodriguez,Carmen, AU - Rohan,Thomas E, AU - Schouten,Leo J, AU - Shore,Roy, AU - Smit,Ellen, AU - Wolk,Alicja, AU - Zhang,Shumin M, AU - Smith-Warner,Stephanie A, PY - 2006/2/24/pubmed PY - 2006/6/16/medline PY - 2006/2/24/entrez SP - 364 EP - 72 JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology JO - Cancer Epidemiol. Biomarkers Prev. VL - 15 IS - 2 N2 - BACKGROUND: Dairy foods and their constituents (lactose and calcium) have been hypothesized to promote ovarian carcinogenesis. Although case-control studies have reported conflicting results for dairy foods and lactose, several cohort studies have shown positive associations between skim milk, lactose, and ovarian cancer. METHODS: A pooled analysis of the primary data from 12 prospective cohort studies was conducted. The study population consisted of 553,217 women among whom 2,132 epithelial ovarian cases were identified. Study-specific relative risks and 95% confidence intervals were calculated by Cox proportional hazards models and then pooled by a random-effects model. RESULTS: No statistically significant associations were observed between intakes of milk, cheese, yogurt, ice cream, and dietary and total calcium intake and risk of ovarian cancer. Higher lactose intakes comparing > or = 30 versus <10 g/d were associated with a statistically significant higher risk of ovarian cancer, although the trend was not statistically significant (pooled multivariate relative risk, 1.19; 95% confidence interval, 1.01-1.40; P(trend) = 0.19). Associations for endometrioid, mucinous, and serous ovarian cancer were similar to the overall findings. DISCUSSION: Overall, no associations were observed for intakes of specific dairy foods or calcium and ovarian cancer risk. A modest elevation in the risk of ovarian cancer was seen for lactose intake at the level that was equivalent to three or more servings of milk per day. Because a new dietary guideline recommends two to three servings of dairy products per day, the relation between dairy product consumption and ovarian cancer risk at these consumption levels deserves further examination. SN - 1055-9965 UR - https://www.unboundmedicine.com/medline/citation/16492930/full_citation L2 - http://cebp.aacrjournals.org/cgi/pmidlookup?view=long&amp;pmid=16492930 DB - PRIME DP - Unbound Medicine ER -