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Acute myeloid leukemia of donor origin after allogeneic bone marrow transplantation for precursor T-cell acute lymphoblastic leukemia: case report and review of the literature.
Am J Hematol. 2006 Mar; 81(3):178-85.AJ

Abstract

We report a case of donor-derived acute myeloid leukemia (AML) occurring in a 33-year-old man after allogeneic bone marrow transplantation (BMT) for precursor T-cell acute lymphoblastic -leukemia (T-ALL). The cells for BMT were from his human leukocyte antigen (HLA)-matched sister. Fluorescence in-situ hybridization (FISH) analysis showed the AML to be of donor origin (i.e., karyotypically female) with an 11q23 (mixed lineage leukemia (MLL) gene) translocation, while the original T-ALL exhibited a male karyotype with abnormalities of chromosomes 6, 8, and a t(10;14)(q24;q11.2). Subsequent molecular short tandem repeat studies confirmed the AML to be of donor origin. Donor-cell leukemia (DCL) after allogeneic BMT is a rare, yet well-documented, event. Our report presents clinicopathologic information about a case of DCL and a review of the recent literature.

Authors+Show Affiliations

Department of Pathology, University of New Mexico, Albuquerque, 87131, USA. kreichard@salud.unm.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

16493618

Citation

Reichard, Kaaren K., et al. "Acute Myeloid Leukemia of Donor Origin After Allogeneic Bone Marrow Transplantation for Precursor T-cell Acute Lymphoblastic Leukemia: Case Report and Review of the Literature." American Journal of Hematology, vol. 81, no. 3, 2006, pp. 178-85.
Reichard KK, Zhang QY, Sanchez L, et al. Acute myeloid leukemia of donor origin after allogeneic bone marrow transplantation for precursor T-cell acute lymphoblastic leukemia: case report and review of the literature. Am J Hematol. 2006;81(3):178-85.
Reichard, K. K., Zhang, Q. Y., Sanchez, L., Hozier, J., Viswanatha, D., & Foucar, K. (2006). Acute myeloid leukemia of donor origin after allogeneic bone marrow transplantation for precursor T-cell acute lymphoblastic leukemia: case report and review of the literature. American Journal of Hematology, 81(3), 178-85.
Reichard KK, et al. Acute Myeloid Leukemia of Donor Origin After Allogeneic Bone Marrow Transplantation for Precursor T-cell Acute Lymphoblastic Leukemia: Case Report and Review of the Literature. Am J Hematol. 2006;81(3):178-85. PubMed PMID: 16493618.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Acute myeloid leukemia of donor origin after allogeneic bone marrow transplantation for precursor T-cell acute lymphoblastic leukemia: case report and review of the literature. AU - Reichard,Kaaren K, AU - Zhang,Qian-Yun, AU - Sanchez,Lorraine, AU - Hozier,John, AU - Viswanatha,David, AU - Foucar,Kathryn, PY - 2006/2/24/pubmed PY - 2006/4/14/medline PY - 2006/2/24/entrez SP - 178 EP - 85 JF - American journal of hematology JO - Am J Hematol VL - 81 IS - 3 N2 - We report a case of donor-derived acute myeloid leukemia (AML) occurring in a 33-year-old man after allogeneic bone marrow transplantation (BMT) for precursor T-cell acute lymphoblastic -leukemia (T-ALL). The cells for BMT were from his human leukocyte antigen (HLA)-matched sister. Fluorescence in-situ hybridization (FISH) analysis showed the AML to be of donor origin (i.e., karyotypically female) with an 11q23 (mixed lineage leukemia (MLL) gene) translocation, while the original T-ALL exhibited a male karyotype with abnormalities of chromosomes 6, 8, and a t(10;14)(q24;q11.2). Subsequent molecular short tandem repeat studies confirmed the AML to be of donor origin. Donor-cell leukemia (DCL) after allogeneic BMT is a rare, yet well-documented, event. Our report presents clinicopathologic information about a case of DCL and a review of the recent literature. SN - 0361-8609 UR - https://www.unboundmedicine.com/medline/citation/16493618/Acute_myeloid_leukemia_of_donor_origin_after_allogeneic_bone_marrow_transplantation_for_precursor_T_cell_acute_lymphoblastic_leukemia:_case_report_and_review_of_the_literature_ L2 - https://doi.org/10.1002/ajh.20389 DB - PRIME DP - Unbound Medicine ER -