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A neuropeptide FF agonist blocks the acquisition of conditioned place preference to morphine in C57Bl/6J mice.
Peptides. 2006 May; 27(5):964-72.P

Abstract

Neuropeptide FF behaves as an opioid-modulating peptide that seems to be involved in morphine tolerance and physical dependence. Nevertheless, the effects of neuropeptide FF agonists on the rewarding properties of morphine remain unknown. C57BL6 mice were conditioned in an unbiased balanced paradigm of conditioned place preference to study the effect of i.c.v. injections of 1DMe (D-Tyr1(NMe)Phe3]NPFF), a stable agonist of the neuropeptide FF system, on the acquisition of place conditioning by morphine or alcohol (ethanol). Morphine (10 mg/kg, i.p.) or ethanol (2 g/kg, i.p.) induced a significant place preference. Injection of 1DMe (1-20 nmol), given 10 min before the i.p. injection of the reinforcing drug during conditioning, inhibited the rewarding effect of morphine but had no effect on the rewarding effect of ethanol. However, a single injection of 1DMe given just before place preference testing was unable to inhibit the rewarding effects of morphine. By itself, 1DMe was inactive but an aversive effect of this agonist could be evidenced if the experimental procedure was biased. These results suggest that neuropeptide FF, injected during conditioning, should influence the development of rewarding effects of morphine and reinforce the hypothesis of strong inhibitory interactions between neuropeptide FF and opioids.

Authors+Show Affiliations

Centre de Recherches sur la Cognition Animale, CNRS UMR 5169, Bât 4R3 b3, Université Paul Sabatier, 118 route de Narbonne, 31062 Toulouse Cedex 4, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16494968

Citation

Marchand, Stéphane, et al. "A Neuropeptide FF Agonist Blocks the Acquisition of Conditioned Place Preference to Morphine in C57Bl/6J Mice." Peptides, vol. 27, no. 5, 2006, pp. 964-72.
Marchand S, Betourne A, Marty V, et al. A neuropeptide FF agonist blocks the acquisition of conditioned place preference to morphine in C57Bl/6J mice. Peptides. 2006;27(5):964-72.
Marchand, S., Betourne, A., Marty, V., Daumas, S., Halley, H., Lassalle, J. M., Zajac, J. M., & Frances, B. (2006). A neuropeptide FF agonist blocks the acquisition of conditioned place preference to morphine in C57Bl/6J mice. Peptides, 27(5), 964-72.
Marchand S, et al. A Neuropeptide FF Agonist Blocks the Acquisition of Conditioned Place Preference to Morphine in C57Bl/6J Mice. Peptides. 2006;27(5):964-72. PubMed PMID: 16494968.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A neuropeptide FF agonist blocks the acquisition of conditioned place preference to morphine in C57Bl/6J mice. AU - Marchand,Stéphane, AU - Betourne,Alexandre, AU - Marty,Virginie, AU - Daumas,Stéphanie, AU - Halley,Hélène, AU - Lassalle,Jean-Michel, AU - Zajac,Jean-Marie, AU - Frances,Bernard, Y1 - 2006/02/21/ PY - 2005/05/23/received PY - 2005/07/21/accepted PY - 2006/2/24/pubmed PY - 2006/7/21/medline PY - 2006/2/24/entrez SP - 964 EP - 72 JF - Peptides JO - Peptides VL - 27 IS - 5 N2 - Neuropeptide FF behaves as an opioid-modulating peptide that seems to be involved in morphine tolerance and physical dependence. Nevertheless, the effects of neuropeptide FF agonists on the rewarding properties of morphine remain unknown. C57BL6 mice were conditioned in an unbiased balanced paradigm of conditioned place preference to study the effect of i.c.v. injections of 1DMe (D-Tyr1(NMe)Phe3]NPFF), a stable agonist of the neuropeptide FF system, on the acquisition of place conditioning by morphine or alcohol (ethanol). Morphine (10 mg/kg, i.p.) or ethanol (2 g/kg, i.p.) induced a significant place preference. Injection of 1DMe (1-20 nmol), given 10 min before the i.p. injection of the reinforcing drug during conditioning, inhibited the rewarding effect of morphine but had no effect on the rewarding effect of ethanol. However, a single injection of 1DMe given just before place preference testing was unable to inhibit the rewarding effects of morphine. By itself, 1DMe was inactive but an aversive effect of this agonist could be evidenced if the experimental procedure was biased. These results suggest that neuropeptide FF, injected during conditioning, should influence the development of rewarding effects of morphine and reinforce the hypothesis of strong inhibitory interactions between neuropeptide FF and opioids. SN - 0196-9781 UR - https://www.unboundmedicine.com/medline/citation/16494968/A_neuropeptide_FF_agonist_blocks_the_acquisition_of_conditioned_place_preference_to_morphine_in_C57Bl/6J_mice_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0196-9781(06)00036-2 DB - PRIME DP - Unbound Medicine ER -