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Prevalence and clinical significance of HGV/GBV-C infection in patients with chronic hepatitis B or C.
Jpn J Infect Dis. 2006 Feb; 59(1):25-30.JJ

Abstract

Hepatitis G virus/GB virus-C (HGV/GBV-C) is a newly identified Flavivirus. Its clinical significance in chronic hepatitis B and C remains controversial. Infection with HGV/GBV-C was surveyed in 500 blood donors, 130 patients with chronic hepatitis B and 173 with hepatitis C, with chronic liver disease, cirrhosis, and/or hepatocellular carcinoma (HCC). HGV/GBV-C RNA was detected by reverse transcription-polymerase chain reaction. An antibody to HGV/GBV-C's second envelope protein (anti-E2 Ab) was detected using an enzyme immunoassay. The prevalence of HGV/GBV-C RNA was 3.4% and the exposure rate 10.2% in blood donors. The prevalence of HGV/GBV-C RNA in patients with chronic hepatitis B and hepatitis C was 7.7 and 17.3%, respectively (P = 0.002). The prevalence of the HGV/GBV-C infection in hepatitis B carriers increased with the severity of chronic liver disease and risk of HCC. The age and duration of hepatitis B virus infection were the more important contributing factors. Clinical and virological characteristics were comparable between those with and without coinfection of HGV/GBV-C and hepatitis C. The seroconversion rate was high. Coinfection of HGV/GBV-C with hepatitis B or C does not affect disease severity, but accelerates the progression of chronic liver disease and the development of HCC.

Authors+Show Affiliations

Department of Preventive Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16495630

Citation

Yang, Jeng-Fu, et al. "Prevalence and Clinical Significance of HGV/GBV-C Infection in Patients With Chronic Hepatitis B or C." Japanese Journal of Infectious Diseases, vol. 59, no. 1, 2006, pp. 25-30.
Yang JF, Dai CY, Chuang WL, et al. Prevalence and clinical significance of HGV/GBV-C infection in patients with chronic hepatitis B or C. Jpn J Infect Dis. 2006;59(1):25-30.
Yang, J. F., Dai, C. Y., Chuang, W. L., Lin, W. Y., Lin, Z. Y., Chen, S. C., Hsieh, M. Y., Wang, L. Y., Tsai, J. F., Chang, W. Y., & Yu, M. L. (2006). Prevalence and clinical significance of HGV/GBV-C infection in patients with chronic hepatitis B or C. Japanese Journal of Infectious Diseases, 59(1), 25-30.
Yang JF, et al. Prevalence and Clinical Significance of HGV/GBV-C Infection in Patients With Chronic Hepatitis B or C. Jpn J Infect Dis. 2006;59(1):25-30. PubMed PMID: 16495630.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevalence and clinical significance of HGV/GBV-C infection in patients with chronic hepatitis B or C. AU - Yang,Jeng-Fu, AU - Dai,Chia-Yen, AU - Chuang,Wan-Long, AU - Lin,Wen-Yi, AU - Lin,Zu-Yau, AU - Chen,Shinn-Cherng, AU - Hsieh,Ming-Yuh, AU - Wang,Liang-Yen, AU - Tsai,Jung-Fa, AU - Chang,Wen-Yu, AU - Yu,Ming-Lung, PY - 2006/2/24/pubmed PY - 2006/6/9/medline PY - 2006/2/24/entrez SP - 25 EP - 30 JF - Japanese journal of infectious diseases JO - Jpn J Infect Dis VL - 59 IS - 1 N2 - Hepatitis G virus/GB virus-C (HGV/GBV-C) is a newly identified Flavivirus. Its clinical significance in chronic hepatitis B and C remains controversial. Infection with HGV/GBV-C was surveyed in 500 blood donors, 130 patients with chronic hepatitis B and 173 with hepatitis C, with chronic liver disease, cirrhosis, and/or hepatocellular carcinoma (HCC). HGV/GBV-C RNA was detected by reverse transcription-polymerase chain reaction. An antibody to HGV/GBV-C's second envelope protein (anti-E2 Ab) was detected using an enzyme immunoassay. The prevalence of HGV/GBV-C RNA was 3.4% and the exposure rate 10.2% in blood donors. The prevalence of HGV/GBV-C RNA in patients with chronic hepatitis B and hepatitis C was 7.7 and 17.3%, respectively (P = 0.002). The prevalence of the HGV/GBV-C infection in hepatitis B carriers increased with the severity of chronic liver disease and risk of HCC. The age and duration of hepatitis B virus infection were the more important contributing factors. Clinical and virological characteristics were comparable between those with and without coinfection of HGV/GBV-C and hepatitis C. The seroconversion rate was high. Coinfection of HGV/GBV-C with hepatitis B or C does not affect disease severity, but accelerates the progression of chronic liver disease and the development of HCC. SN - 1344-6304 UR - https://www.unboundmedicine.com/medline/citation/16495630/Prevalence_and_clinical_significance_of_HGV/GBV_C_infection_in_patients_with_chronic_hepatitis_B_or_C_ L2 - http://www.diseaseinfosearch.org/result/3332 DB - PRIME DP - Unbound Medicine ER -