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Nicotine pre-exposure does not potentiate the locomotor or rewarding effects of Delta-9-tetrahydrocannabinol in rats.
Behav Pharmacol. 2006 Mar; 17(2):195-9.BP

Abstract

This study assessed the effects of nicotine pre-exposure on subsequent locomotor and rewarding effects of repeated Delta-9-tetrahydrocannabinol administration in Sprague-Dawley rats. Repeated administration of the same dose of Delta-9-tetrahydrocannabinol (0.01-2 mg/kg) did not produce significant tolerance or behavioral sensitization to Delta-9-tetrahydrocannabinol's locomotor effects. An unbiased place conditioning paradigm was then used to obtain a measure of the rewarding effects of Delta-9-tetrahydrocannabinol. Rats received an injection of either Delta-9-tetrahydrocannabinol (0.01-2 mg/kg) before being placed in one compartment (three trials) or saline before being placed in the other compartment (three trials) of a two-compartment apparatus. Control rats received saline injections associated with both compartments. Significant conditioned place preferences developed with 0.1 mg/kg Delta-9-tetrahydrocannabinol in control rats, but not in nicotine pre-exposed rats. Surprisingly, significant place aversions developed at higher 1 and 2 mg/kg doses of Delta-9-tetrahydrocannabinol in nicotine pre-exposed rats. To the extent that behavioral sensitization may reflect reward processes in drug dependence, the lack of behavioral sensitization on repeated Delta-9-tetrahydrocannabinol administration is consistent with the difficulties usually encountered in demonstrating rewarding or reinforcing effects of Delta-9-tetrahydrocannabinol in rats. The present findings suggest, moreover, that nicotine pre-exposure alters the qualitative nature of rewarding effects and accentuates aversive effects of Delta-9-tetrahydrocannabinol.

Authors+Show Affiliations

Le Foll B
Preclinical Pharmacology Section, Behavioral Neuroscience Research Branch, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland 21224, USA. blefoll@intra.nida.nih.gov
Wiggins M
No affiliation info available
Goldberg SR
No affiliation info available

MeSH

AnimalsDose-Response Relationship, DrugDronabinolDrug InteractionsHallucinogensMaleMotor ActivityNicotineNicotinic AgonistsRatsRats, Sprague-DawleyReward

Pub Type(s)

Journal Article
Research Support, N.I.H., Intramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16495727

Citation

Le Foll, Bernard, et al. "Nicotine Pre-exposure Does Not Potentiate the Locomotor or Rewarding Effects of Delta-9-tetrahydrocannabinol in Rats." Behavioural Pharmacology, vol. 17, no. 2, 2006, pp. 195-9.
Le Foll B, Wiggins M, Goldberg SR. Nicotine pre-exposure does not potentiate the locomotor or rewarding effects of Delta-9-tetrahydrocannabinol in rats. Behav Pharmacol. 2006;17(2):195-9.
Le Foll, B., Wiggins, M., & Goldberg, S. R. (2006). Nicotine pre-exposure does not potentiate the locomotor or rewarding effects of Delta-9-tetrahydrocannabinol in rats. Behavioural Pharmacology, 17(2), 195-9.
Le Foll B, Wiggins M, Goldberg SR. Nicotine Pre-exposure Does Not Potentiate the Locomotor or Rewarding Effects of Delta-9-tetrahydrocannabinol in Rats. Behav Pharmacol. 2006;17(2):195-9. PubMed PMID: 16495727.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Nicotine pre-exposure does not potentiate the locomotor or rewarding effects of Delta-9-tetrahydrocannabinol in rats. AU - Le Foll,Bernard, AU - Wiggins,Marcus, AU - Goldberg,Steven R, PY - 2006/2/24/pubmed PY - 2006/12/9/medline PY - 2006/2/24/entrez SP - 195 EP - 9 JF - Behavioural pharmacology JO - Behav Pharmacol VL - 17 IS - 2 N2 - This study assessed the effects of nicotine pre-exposure on subsequent locomotor and rewarding effects of repeated Delta-9-tetrahydrocannabinol administration in Sprague-Dawley rats. Repeated administration of the same dose of Delta-9-tetrahydrocannabinol (0.01-2 mg/kg) did not produce significant tolerance or behavioral sensitization to Delta-9-tetrahydrocannabinol's locomotor effects. An unbiased place conditioning paradigm was then used to obtain a measure of the rewarding effects of Delta-9-tetrahydrocannabinol. Rats received an injection of either Delta-9-tetrahydrocannabinol (0.01-2 mg/kg) before being placed in one compartment (three trials) or saline before being placed in the other compartment (three trials) of a two-compartment apparatus. Control rats received saline injections associated with both compartments. Significant conditioned place preferences developed with 0.1 mg/kg Delta-9-tetrahydrocannabinol in control rats, but not in nicotine pre-exposed rats. Surprisingly, significant place aversions developed at higher 1 and 2 mg/kg doses of Delta-9-tetrahydrocannabinol in nicotine pre-exposed rats. To the extent that behavioral sensitization may reflect reward processes in drug dependence, the lack of behavioral sensitization on repeated Delta-9-tetrahydrocannabinol administration is consistent with the difficulties usually encountered in demonstrating rewarding or reinforcing effects of Delta-9-tetrahydrocannabinol in rats. The present findings suggest, moreover, that nicotine pre-exposure alters the qualitative nature of rewarding effects and accentuates aversive effects of Delta-9-tetrahydrocannabinol. SN - 0955-8810 UR - https://www.unboundmedicine.com/medline/citation/16495727/Nicotine_pre_exposure_does_not_potentiate_the_locomotor_or_rewarding_effects_of_Delta_9_tetrahydrocannabinol_in_rats_ DB - PRIME DP - Unbound Medicine ER -