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Alcohol intake and ovarian cancer risk: a pooled analysis of 10 cohort studies.
Br J Cancer. 2006 Mar 13; 94(5):757-62.BJ

Abstract

Alcohol has been hypothesized to promote ovarian carcinogenesis by its potential to increase circulating levels of estrogen and other hormones; through its oxidation byproduct, acetaldehyde, which may act as a cocarcinogen; and by depletion of folate and other nutrients. Case-control and cohort studies have reported conflicting results relating alcohol intake to ovarian cancer risk. We conducted a pooled analysis of the primary data from ten prospective cohort studies. The analysis included 529 638 women among whom 2001 incident epithelial ovarian cases were documented. After study-specific relative risks (RR) and 95% confidence intervals (CI) were calculated by Cox proportional hazards models, and then were pooled using a random effects model; no associations were observed for intakes of total alcohol (pooled multivariate RR=1.12, 95% CI 0.86-1.44 comparing > or =30 to 0 g day(-1) of alcohol) or alcohol from wine, beer or spirits and ovarian cancer risk. The association with alcohol consumption was not modified by oral contraceptive use, hormone replacement therapy, parity, menopausal status, folate intake, body mass index, or smoking. Associations for endometrioid, mucinous, and serous ovarian cancer were similar to the overall findings. This pooled analysis does not support an association between moderate alcohol intake and ovarian cancer risk.

Authors+Show Affiliations

Department of Nutrition, Harvard School of Public Health, Boston, MA, USA. pooling@hsphsun2.harvard.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

16495916

Citation

Genkinger, J M., et al. "Alcohol Intake and Ovarian Cancer Risk: a Pooled Analysis of 10 Cohort Studies." British Journal of Cancer, vol. 94, no. 5, 2006, pp. 757-62.
Genkinger JM, Hunter DJ, Spiegelman D, et al. Alcohol intake and ovarian cancer risk: a pooled analysis of 10 cohort studies. Br J Cancer. 2006;94(5):757-62.
Genkinger, J. M., Hunter, D. J., Spiegelman, D., Anderson, K. E., Buring, J. E., Freudenheim, J. L., Goldbohm, R. A., Harnack, L., Hankinson, S. E., Larsson, S. C., Leitzmann, M., McCullough, M. L., Marshall, J., Miller, A. B., Rodriguez, C., Rohan, T. E., Schatzkin, A., Schouten, L. J., Wolk, A., ... Smith-Warner, S. A. (2006). Alcohol intake and ovarian cancer risk: a pooled analysis of 10 cohort studies. British Journal of Cancer, 94(5), 757-62.
Genkinger JM, et al. Alcohol Intake and Ovarian Cancer Risk: a Pooled Analysis of 10 Cohort Studies. Br J Cancer. 2006 Mar 13;94(5):757-62. PubMed PMID: 16495916.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Alcohol intake and ovarian cancer risk: a pooled analysis of 10 cohort studies. AU - Genkinger,J M, AU - Hunter,D J, AU - Spiegelman,D, AU - Anderson,K E, AU - Buring,J E, AU - Freudenheim,J L, AU - Goldbohm,R A, AU - Harnack,L, AU - Hankinson,S E, AU - Larsson,S C, AU - Leitzmann,M, AU - McCullough,M L, AU - Marshall,J, AU - Miller,A B, AU - Rodriguez,C, AU - Rohan,T E, AU - Schatzkin,A, AU - Schouten,L J, AU - Wolk,A, AU - Zhang,S M, AU - Smith-Warner,S A, PY - 2006/2/24/pubmed PY - 2006/4/6/medline PY - 2006/2/24/entrez SP - 757 EP - 62 JF - British journal of cancer JO - Br. J. Cancer VL - 94 IS - 5 N2 - Alcohol has been hypothesized to promote ovarian carcinogenesis by its potential to increase circulating levels of estrogen and other hormones; through its oxidation byproduct, acetaldehyde, which may act as a cocarcinogen; and by depletion of folate and other nutrients. Case-control and cohort studies have reported conflicting results relating alcohol intake to ovarian cancer risk. We conducted a pooled analysis of the primary data from ten prospective cohort studies. The analysis included 529 638 women among whom 2001 incident epithelial ovarian cases were documented. After study-specific relative risks (RR) and 95% confidence intervals (CI) were calculated by Cox proportional hazards models, and then were pooled using a random effects model; no associations were observed for intakes of total alcohol (pooled multivariate RR=1.12, 95% CI 0.86-1.44 comparing > or =30 to 0 g day(-1) of alcohol) or alcohol from wine, beer or spirits and ovarian cancer risk. The association with alcohol consumption was not modified by oral contraceptive use, hormone replacement therapy, parity, menopausal status, folate intake, body mass index, or smoking. Associations for endometrioid, mucinous, and serous ovarian cancer were similar to the overall findings. This pooled analysis does not support an association between moderate alcohol intake and ovarian cancer risk. SN - 0007-0920 UR - https://www.unboundmedicine.com/medline/citation/16495916/Alcohol_intake_and_ovarian_cancer_risk:_a_pooled_analysis_of_10_cohort_studies_ L2 - http://dx.doi.org/10.1038/sj.bjc.6603020 DB - PRIME DP - Unbound Medicine ER -