[Synthesis of camptothecin glycosides by phase transfer-catalysis and its inhibitory activity against topo I].Yao Xue Xue Bao. 2005 Dec; 40(12):1116-21.YX
Abstract
AIM
To find new anticancer drug based on the structure of 10-hydroxy camptothecin.
METHODS
Six camptothecin glycosides (7-12) were synthesized by phase transfer catalysis. The structures of all compounds synthesized were determined by 1H NMR, IR and MS. Their antitumor activity was evaluated on cancer cells in vitro, and inhibitory activity against Topo I was evaluated by molecular biologic method.
RESULTS AND CONCLUSION
The result indicated that the yield of camptothecin glycosides by phase transfer catalysis is much higher than by the method from literature, camptothecin glycosides have much lower cytotoxicities on cancer cell in vitro, but have better inhibitory activity of topo I.
MeSH
Pub Type(s)
English Abstract
Journal Article
Research Support, Non-U.S. Gov't
Language
chi
PubMed ID
16496676
Citation
Li, Qing-yong, et al. "[Synthesis of Camptothecin Glycosides By Phase Transfer-catalysis and Its Inhibitory Activity Against Topo I]." Yao Xue Xue Bao = Acta Pharmaceutica Sinica, vol. 40, no. 12, 2005, pp. 1116-21.
Li QY, Zhang Y, Yao LP, et al. [Synthesis of camptothecin glycosides by phase transfer-catalysis and its inhibitory activity against topo I]. Yao Xue Xue Bao. 2005;40(12):1116-21.
Li, Q. Y., Zhang, Y., Yao, L. P., Fu, Y. J., Zu, Y. G., Chen, X. Q., & Zheng, C. Y. (2005). [Synthesis of camptothecin glycosides by phase transfer-catalysis and its inhibitory activity against topo I]. Yao Xue Xue Bao = Acta Pharmaceutica Sinica, 40(12), 1116-21.
Li QY, et al. [Synthesis of Camptothecin Glycosides By Phase Transfer-catalysis and Its Inhibitory Activity Against Topo I]. Yao Xue Xue Bao. 2005;40(12):1116-21. PubMed PMID: 16496676.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR
T1 - [Synthesis of camptothecin glycosides by phase transfer-catalysis and its inhibitory activity against topo I].
AU - Li,Qing-yong,
AU - Zhang,Ying,
AU - Yao,Li-ping,
AU - Fu,Yu-jie,
AU - Zu,Yuan-gang,
AU - Chen,Xiao-qiang,
AU - Zheng,Chun-ying,
PY - 2006/2/25/pubmed
PY - 2007/8/7/medline
PY - 2006/2/25/entrez
SP - 1116
EP - 21
JF - Yao xue xue bao = Acta pharmaceutica Sinica
JO - Yao Xue Xue Bao
VL - 40
IS - 12
N2 - AIM: To find new anticancer drug based on the structure of 10-hydroxy camptothecin. METHODS: Six camptothecin glycosides (7-12) were synthesized by phase transfer catalysis. The structures of all compounds synthesized were determined by 1H NMR, IR and MS. Their antitumor activity was evaluated on cancer cells in vitro, and inhibitory activity against Topo I was evaluated by molecular biologic method. RESULTS AND CONCLUSION: The result indicated that the yield of camptothecin glycosides by phase transfer catalysis is much higher than by the method from literature, camptothecin glycosides have much lower cytotoxicities on cancer cell in vitro, but have better inhibitory activity of topo I.
SN - 0513-4870
UR - https://www.unboundmedicine.com/medline/citation/16496676/[Synthesis_of_camptothecin_glycosides_by_phase_transfer_catalysis_and_its_inhibitory_activity_against_topo_I]_
DB - PRIME
DP - Unbound Medicine
ER -