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[Synthesis of camptothecin glycosides by phase transfer-catalysis and its inhibitory activity against topo I].
Yao Xue Xue Bao. 2005 Dec; 40(12):1116-21.YX

Abstract

AIM

To find new anticancer drug based on the structure of 10-hydroxy camptothecin.

METHODS

Six camptothecin glycosides (7-12) were synthesized by phase transfer catalysis. The structures of all compounds synthesized were determined by 1H NMR, IR and MS. Their antitumor activity was evaluated on cancer cells in vitro, and inhibitory activity against Topo I was evaluated by molecular biologic method.

RESULTS AND CONCLUSION

The result indicated that the yield of camptothecin glycosides by phase transfer catalysis is much higher than by the method from literature, camptothecin glycosides have much lower cytotoxicities on cancer cell in vitro, but have better inhibitory activity of topo I.

Authors+Show Affiliations

Li QY
Key Laboratory of Forest Plant Ecology of Northeast Forestry University, Ministry of Education, Harbin 150040, China.
Zhang Y
No affiliation info available
Yao LP
No affiliation info available
Fu YJ
No affiliation info available
Zu YG
No affiliation info available
Chen XQ
No affiliation info available
Zheng CY
No affiliation info available

MeSH

Antineoplastic Agents, PhytogenicCamptothecinDNA Topoisomerases, Type IGlycosidesHumansMolecular ConformationMolecular StructureTumor Cells, Cultured

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

16496676

Citation

Li, Qing-yong, et al. "[Synthesis of Camptothecin Glycosides By Phase Transfer-catalysis and Its Inhibitory Activity Against Topo I]." Yao Xue Xue Bao = Acta Pharmaceutica Sinica, vol. 40, no. 12, 2005, pp. 1116-21.
Li QY, Zhang Y, Yao LP, et al. [Synthesis of camptothecin glycosides by phase transfer-catalysis and its inhibitory activity against topo I]. Yao Xue Xue Bao. 2005;40(12):1116-21.
Li, Q. Y., Zhang, Y., Yao, L. P., Fu, Y. J., Zu, Y. G., Chen, X. Q., & Zheng, C. Y. (2005). [Synthesis of camptothecin glycosides by phase transfer-catalysis and its inhibitory activity against topo I]. Yao Xue Xue Bao = Acta Pharmaceutica Sinica, 40(12), 1116-21.
Li QY, et al. [Synthesis of Camptothecin Glycosides By Phase Transfer-catalysis and Its Inhibitory Activity Against Topo I]. Yao Xue Xue Bao. 2005;40(12):1116-21. PubMed PMID: 16496676.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Synthesis of camptothecin glycosides by phase transfer-catalysis and its inhibitory activity against topo I]. AU - Li,Qing-yong, AU - Zhang,Ying, AU - Yao,Li-ping, AU - Fu,Yu-jie, AU - Zu,Yuan-gang, AU - Chen,Xiao-qiang, AU - Zheng,Chun-ying, PY - 2006/2/25/pubmed PY - 2007/8/7/medline PY - 2006/2/25/entrez SP - 1116 EP - 21 JF - Yao xue xue bao = Acta pharmaceutica Sinica JO - Yao Xue Xue Bao VL - 40 IS - 12 N2 - AIM: To find new anticancer drug based on the structure of 10-hydroxy camptothecin. METHODS: Six camptothecin glycosides (7-12) were synthesized by phase transfer catalysis. The structures of all compounds synthesized were determined by 1H NMR, IR and MS. Their antitumor activity was evaluated on cancer cells in vitro, and inhibitory activity against Topo I was evaluated by molecular biologic method. RESULTS AND CONCLUSION: The result indicated that the yield of camptothecin glycosides by phase transfer catalysis is much higher than by the method from literature, camptothecin glycosides have much lower cytotoxicities on cancer cell in vitro, but have better inhibitory activity of topo I. SN - 0513-4870 UR - https://www.unboundmedicine.com/medline/citation/16496676/[Synthesis_of_camptothecin_glycosides_by_phase_transfer_catalysis_and_its_inhibitory_activity_against_topo_I]_ DB - PRIME DP - Unbound Medicine ER -