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Helicobacter pylori infection in 1st degree relatives of Chinese gastric cancer patients.
Scand J Gastroenterol. 2006 Mar; 41(3):274-9.SJ

Abstract

OBJECTIVE

Familial aggregation of gastric cancer has been linked to familial clustering of Helicobacter pylori infection. Patterns and risk factors associated with H. pylori infection were investigated in 1st degree relatives of Chinese gastric cancer patients.

MATERIAL AND METHODS

Gastric cancer relatives were invited for screening endoscopy. H. pylori infection was diagnosed by endoscopic and serological methods.

RESULTS

Among the 270 cancer relatives examined, 161 (59.6%) were found to be infected with H. pylori. The prevalence of infection in cancer relatives was significantly higher than age- and gender-matched dyspeptic control (45.5%, p=0.0006). The mean age of H. pylori-infected relatives was significantly older than that of non-infected relatives (43.9 versus 38.3 years; p<0.001). The prevalence of H. pylori infection was higher in those with more siblings (p=0.013, chi(2) test for trend). Moreover, individuals whose siblings had stomach cancer were more likely to have H. pylori infection than those with a parental history of cancer (68.2% versus 51.8%, p=0.007). In contrast, the youngest sibling had a significantly lower H. pylori infection rate than other siblings (39.2% versus 64.2%, p=0.001). Using multiple logistic regression, it was found that age >45 years (OR=1.8; 95% CI, 1.02-3.3) and a history of gastric cancer in siblings (OR=1.9; 95% CI, 1.06-3.3) were independent risk factors for H. pylori infection, and that the youngest sibling in the family had a reduced risk (OR=0.45; 95% CI, 0.24-0.84).

CONCLUSIONS

This study identifies the patterns and risk factors for H. pylori in gastric cancer relatives, which may shed light on the evolving epidemiology of H. pylori infection in Chinese patients.

Authors+Show Affiliations

Institute of Digestive Diseases, Shatin, Hong Kong. wkleung@cuhk.edu.hkNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16497613

Citation

Leung, Wai K., et al. "Helicobacter Pylori Infection in 1st Degree Relatives of Chinese Gastric Cancer Patients." Scandinavian Journal of Gastroenterology, vol. 41, no. 3, 2006, pp. 274-9.
Leung WK, Ng EK, Lam CC, et al. Helicobacter pylori infection in 1st degree relatives of Chinese gastric cancer patients. Scand J Gastroenterol. 2006;41(3):274-9.
Leung, W. K., Ng, E. K., Lam, C. C., Chan, K. F., Chan, W. Y., Auyeung, A. C., Wu, J. C., Ching, J. Y., Lau, J. Y., & Sung, J. J. (2006). Helicobacter pylori infection in 1st degree relatives of Chinese gastric cancer patients. Scandinavian Journal of Gastroenterology, 41(3), 274-9.
Leung WK, et al. Helicobacter Pylori Infection in 1st Degree Relatives of Chinese Gastric Cancer Patients. Scand J Gastroenterol. 2006;41(3):274-9. PubMed PMID: 16497613.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Helicobacter pylori infection in 1st degree relatives of Chinese gastric cancer patients. AU - Leung,Wai K, AU - Ng,Enders K W, AU - Lam,Candice C H, AU - Chan,Kui-Fat, AU - Chan,Wing Y, AU - Auyeung,Alex C M, AU - Wu,Justin C Y, AU - Ching,Jessica Y L, AU - Lau,James Y W, AU - Sung,Joseph J Y, PY - 2006/2/25/pubmed PY - 2006/7/21/medline PY - 2006/2/25/entrez SP - 274 EP - 9 JF - Scandinavian journal of gastroenterology JO - Scand. J. Gastroenterol. VL - 41 IS - 3 N2 - OBJECTIVE: Familial aggregation of gastric cancer has been linked to familial clustering of Helicobacter pylori infection. Patterns and risk factors associated with H. pylori infection were investigated in 1st degree relatives of Chinese gastric cancer patients. MATERIAL AND METHODS: Gastric cancer relatives were invited for screening endoscopy. H. pylori infection was diagnosed by endoscopic and serological methods. RESULTS: Among the 270 cancer relatives examined, 161 (59.6%) were found to be infected with H. pylori. The prevalence of infection in cancer relatives was significantly higher than age- and gender-matched dyspeptic control (45.5%, p=0.0006). The mean age of H. pylori-infected relatives was significantly older than that of non-infected relatives (43.9 versus 38.3 years; p<0.001). The prevalence of H. pylori infection was higher in those with more siblings (p=0.013, chi(2) test for trend). Moreover, individuals whose siblings had stomach cancer were more likely to have H. pylori infection than those with a parental history of cancer (68.2% versus 51.8%, p=0.007). In contrast, the youngest sibling had a significantly lower H. pylori infection rate than other siblings (39.2% versus 64.2%, p=0.001). Using multiple logistic regression, it was found that age >45 years (OR=1.8; 95% CI, 1.02-3.3) and a history of gastric cancer in siblings (OR=1.9; 95% CI, 1.06-3.3) were independent risk factors for H. pylori infection, and that the youngest sibling in the family had a reduced risk (OR=0.45; 95% CI, 0.24-0.84). CONCLUSIONS: This study identifies the patterns and risk factors for H. pylori in gastric cancer relatives, which may shed light on the evolving epidemiology of H. pylori infection in Chinese patients. SN - 0036-5521 UR - https://www.unboundmedicine.com/medline/citation/16497613/Helicobacter_pylori_infection_in_1st_degree_relatives_of_Chinese_gastric_cancer_patients_ L2 - http://www.tandfonline.com/doi/full/10.1080/00365520510024269 DB - PRIME DP - Unbound Medicine ER -