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Live high-train low for 24 days increases hemoglobin mass and red cell volume in elite endurance athletes.
J Appl Physiol (1985). 2006 Jun; 100(6):1938-45.JA

Abstract

The effect of live high-train low on hemoglobin mass (Hbmass) and red cell volume (RCV) in elite endurance athletes is still controversial. We expected that Hb(mass) and RCV would increase, when using a presumably adequate hypoxic dose. An altitude group (AG) of 10 Swiss national team orienteers (5 men and 5 women) lived at 2,500 m (18 h per day) and trained at 1,800 and 1,000 m above sea level for 24 days. Before and after altitude, Hbmass, RCV (carbon monoxide rebreathing method), blood, iron, and performance parameters were determined. Seven Swiss national team cross-country skiers (3 men and 4 women) served as "sea level" (500-1,600 m) control group (CG) for the changes in Hbmass and RCV. The AG increased Hbmass (805+/-209 vs. 848+/-225 g; P<0.01) and RCV (2,353+/-611 vs. 2,470+/-653 ml; P<0.01), whereas there was no change for the CG (Hbmass: 849+/-197 vs. 858+/-205 g; RCV: 2,373+/-536 vs. 2,387+/-551 ml). Serum erythropoietin (P<0.001), reticulocytes (P<0.001), transferrin (P<0.001), soluble transferrin receptor (P<0.05), and hematocrit (P<0.01) increased, whereas ferritin (P<0.05) decreased in the AG. These changes were associated with an increased maximal oxygen uptake (3,515+/-837 vs. 3,660+/-770 ml/min; P<0.05) and improved 5,000-m running times (1,098+/-104 vs. 1,080+/-98 s; P<0.01) from pre- to postaltitude. Living at 2,500 m and training at lower altitudes for 24 days increases Hbmass and RCV. These changes may contribute to enhance performance of elite endurance athletes.

Authors+Show Affiliations

Swiss Federal Institute of Sports, Section for Elite Sport, 2532 Magglingen, Switzerland. jon.wehrlin@baspo.admin.chNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article

Language

eng

PubMed ID

16497842

Citation

Wehrlin, Jon Peter, et al. "Live High-train Low for 24 Days Increases Hemoglobin Mass and Red Cell Volume in Elite Endurance Athletes." Journal of Applied Physiology (Bethesda, Md. : 1985), vol. 100, no. 6, 2006, pp. 1938-45.
Wehrlin JP, Zuest P, Hallén J, et al. Live high-train low for 24 days increases hemoglobin mass and red cell volume in elite endurance athletes. J Appl Physiol. 2006;100(6):1938-45.
Wehrlin, J. P., Zuest, P., Hallén, J., & Marti, B. (2006). Live high-train low for 24 days increases hemoglobin mass and red cell volume in elite endurance athletes. Journal of Applied Physiology (Bethesda, Md. : 1985), 100(6), 1938-45.
Wehrlin JP, et al. Live High-train Low for 24 Days Increases Hemoglobin Mass and Red Cell Volume in Elite Endurance Athletes. J Appl Physiol. 2006;100(6):1938-45. PubMed PMID: 16497842.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Live high-train low for 24 days increases hemoglobin mass and red cell volume in elite endurance athletes. AU - Wehrlin,Jon Peter, AU - Zuest,Peter, AU - Hallén,Jostein, AU - Marti,Bernard, Y1 - 2006/02/23/ PY - 2006/2/25/pubmed PY - 2006/8/5/medline PY - 2006/2/25/entrez SP - 1938 EP - 45 JF - Journal of applied physiology (Bethesda, Md. : 1985) JO - J. Appl. Physiol. VL - 100 IS - 6 N2 - The effect of live high-train low on hemoglobin mass (Hbmass) and red cell volume (RCV) in elite endurance athletes is still controversial. We expected that Hb(mass) and RCV would increase, when using a presumably adequate hypoxic dose. An altitude group (AG) of 10 Swiss national team orienteers (5 men and 5 women) lived at 2,500 m (18 h per day) and trained at 1,800 and 1,000 m above sea level for 24 days. Before and after altitude, Hbmass, RCV (carbon monoxide rebreathing method), blood, iron, and performance parameters were determined. Seven Swiss national team cross-country skiers (3 men and 4 women) served as "sea level" (500-1,600 m) control group (CG) for the changes in Hbmass and RCV. The AG increased Hbmass (805+/-209 vs. 848+/-225 g; P<0.01) and RCV (2,353+/-611 vs. 2,470+/-653 ml; P<0.01), whereas there was no change for the CG (Hbmass: 849+/-197 vs. 858+/-205 g; RCV: 2,373+/-536 vs. 2,387+/-551 ml). Serum erythropoietin (P<0.001), reticulocytes (P<0.001), transferrin (P<0.001), soluble transferrin receptor (P<0.05), and hematocrit (P<0.01) increased, whereas ferritin (P<0.05) decreased in the AG. These changes were associated with an increased maximal oxygen uptake (3,515+/-837 vs. 3,660+/-770 ml/min; P<0.05) and improved 5,000-m running times (1,098+/-104 vs. 1,080+/-98 s; P<0.01) from pre- to postaltitude. Living at 2,500 m and training at lower altitudes for 24 days increases Hbmass and RCV. These changes may contribute to enhance performance of elite endurance athletes. SN - 8750-7587 UR - https://www.unboundmedicine.com/medline/citation/16497842/Live_high_train_low_for_24_days_increases_hemoglobin_mass_and_red_cell_volume_in_elite_endurance_athletes_ L2 - http://www.physiology.org/doi/full/10.1152/japplphysiol.01284.2005?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -