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Association of renal function and delta-aminolevulinic acid dehydratase polymorphism among Vietnamese and Singapore workers exposed to inorganic lead.
Occup Environ Med 2006; 63(3):180-6OE

Abstract

OBJECTIVES

To investigate the effect of delta-aminolevulinic acid dehydratase (ALAD) polymorphisms on the association between blood lead and renal function among Vietnamese and Singaporean workers who were exposed to low to medium levels of inorganic lead, and to study the distribution of ALAD polymorphism among Vietnamese, Chinese, Malays and Indians.

METHODS

A total of 459 male and female workers were studied. Blood and urine were collected for each worker in order to determine ALAD genotype, blood lead, and urinary delta-aminolevulinic acid (ALAU). Renal function tests included urine albumin (Ualb), urine beta2 microglobulin (Ubeta2m), urinary alpha1 microglobulin (Ualpha1m), N-acetyl-glucosaminidas (NAG), and urine retinol blinding protein (RBP). A multiple regression model with interaction term was applied to fit the entire data and to explore the modifying effect of ALAD polymorphism on the relation of blood lead to each renal function parameter.

RESULTS

ALAD1-1 was the predominant genotype for all the ethnic groups while ALAD2-2 was the rarest. The frequency of ALAD2 allele was higher among Malays (8.8%) and Indians (10.6%) compared to the Chinese (5.0%) and Vietnamese (4.3%). The geometric mean of blood lead for all workers was 19.0 microg/dl. The models for Ubeta2m, Ualpha1m, and NAG showed that the ALAD1-2/2-2 group had higher beta coefficients than the ALAD1-1 group. Corresponding to 10 microg/dl blood lead, ALAD1-1 homozygotes had an increment of 1.288 microg/g Cr, 1.175 mg/g Cr, and 1.995 U/g Cr for Ubeta2m, Ualpha1m, and NAG, respectively. ALAD1-2/2-2 subjects had higher increments of 3.802 microg/g Cr, 2.138 mg/g Cr, and 3.89 U/g Cr for Ubeta2m, Ualpha1m, and NAG, respectively.

CONCLUSION

The frequency of the ALAD2 allele is as low in Vietnamese workers as in Chinese. Workers with the ALAD2 allele appeared more susceptible to the effects of lead (especially at higher levels) on renal function.

Authors+Show Affiliations

Department of Community, Occupational & Family Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore. cofcse@nus.edu.sgNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16497859

Citation

Chia, S-E, et al. "Association of Renal Function and Delta-aminolevulinic Acid Dehydratase Polymorphism Among Vietnamese and Singapore Workers Exposed to Inorganic Lead." Occupational and Environmental Medicine, vol. 63, no. 3, 2006, pp. 180-6.
Chia SE, Zhou HJ, Yap E, et al. Association of renal function and delta-aminolevulinic acid dehydratase polymorphism among Vietnamese and Singapore workers exposed to inorganic lead. Occup Environ Med. 2006;63(3):180-6.
Chia, S. E., Zhou, H. J., Yap, E., Tham, M. T., Dong, N. V., Hong Tu, N. T., & Chia, K. S. (2006). Association of renal function and delta-aminolevulinic acid dehydratase polymorphism among Vietnamese and Singapore workers exposed to inorganic lead. Occupational and Environmental Medicine, 63(3), pp. 180-6.
Chia SE, et al. Association of Renal Function and Delta-aminolevulinic Acid Dehydratase Polymorphism Among Vietnamese and Singapore Workers Exposed to Inorganic Lead. Occup Environ Med. 2006;63(3):180-6. PubMed PMID: 16497859.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association of renal function and delta-aminolevulinic acid dehydratase polymorphism among Vietnamese and Singapore workers exposed to inorganic lead. AU - Chia,S-E, AU - Zhou,H J, AU - Yap,E, AU - Tham,M T, AU - Dong,N-V, AU - Hong Tu,N T, AU - Chia,K-S, PY - 2006/2/25/pubmed PY - 2006/4/1/medline PY - 2006/2/25/entrez SP - 180 EP - 6 JF - Occupational and environmental medicine JO - Occup Environ Med VL - 63 IS - 3 N2 - OBJECTIVES: To investigate the effect of delta-aminolevulinic acid dehydratase (ALAD) polymorphisms on the association between blood lead and renal function among Vietnamese and Singaporean workers who were exposed to low to medium levels of inorganic lead, and to study the distribution of ALAD polymorphism among Vietnamese, Chinese, Malays and Indians. METHODS: A total of 459 male and female workers were studied. Blood and urine were collected for each worker in order to determine ALAD genotype, blood lead, and urinary delta-aminolevulinic acid (ALAU). Renal function tests included urine albumin (Ualb), urine beta2 microglobulin (Ubeta2m), urinary alpha1 microglobulin (Ualpha1m), N-acetyl-glucosaminidas (NAG), and urine retinol blinding protein (RBP). A multiple regression model with interaction term was applied to fit the entire data and to explore the modifying effect of ALAD polymorphism on the relation of blood lead to each renal function parameter. RESULTS: ALAD1-1 was the predominant genotype for all the ethnic groups while ALAD2-2 was the rarest. The frequency of ALAD2 allele was higher among Malays (8.8%) and Indians (10.6%) compared to the Chinese (5.0%) and Vietnamese (4.3%). The geometric mean of blood lead for all workers was 19.0 microg/dl. The models for Ubeta2m, Ualpha1m, and NAG showed that the ALAD1-2/2-2 group had higher beta coefficients than the ALAD1-1 group. Corresponding to 10 microg/dl blood lead, ALAD1-1 homozygotes had an increment of 1.288 microg/g Cr, 1.175 mg/g Cr, and 1.995 U/g Cr for Ubeta2m, Ualpha1m, and NAG, respectively. ALAD1-2/2-2 subjects had higher increments of 3.802 microg/g Cr, 2.138 mg/g Cr, and 3.89 U/g Cr for Ubeta2m, Ualpha1m, and NAG, respectively. CONCLUSION: The frequency of the ALAD2 allele is as low in Vietnamese workers as in Chinese. Workers with the ALAD2 allele appeared more susceptible to the effects of lead (especially at higher levels) on renal function. SN - 1470-7926 UR - https://www.unboundmedicine.com/medline/citation/16497859/Association_of_renal_function_and_delta_aminolevulinic_acid_dehydratase_polymorphism_among_Vietnamese_and_Singapore_workers_exposed_to_inorganic_lead_ L2 - http://oem.bmj.com/cgi/pmidlookup?view=long&pmid=16497859 DB - PRIME DP - Unbound Medicine ER -