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Regional sharing for adult status 1 candidates: reduction in waitlist mortality.
Liver Transpl. 2006 Mar; 12(3):470-4.LT

Abstract

The intent of regional sharing for status 1 candidates is to promote timely access to donor livers. Presumably this decreases waitlist mortality. Little published data exists that supports this policy. Organ Procurement and Transplantation Network data was used to calculate region 4 and national adult waitlist death and transplant rates 4 yr prior to (period A) and after (period B) implementation of the sharing agreement in July 1999. Death and transplant rates were calculated using a competing risk analysis. Regional sharing resulted in a reduction in adult status 1 waitlist death rate and an increase in transplant rate for region 4 candidates at 7 and 14 days (P > 0.05) without a change in the death rate at 90 days for the non-status 1 candidates. National data showed a significant increase in transplant rate at 7 days and reduction in waitlist death rate at 14 days after listing (P < 0.05). Status 1 waiting time was decreased from 10 to 3 days (P < 0.05). Adult patient survival was not significantly different between the periods. In conclusion, regional sharing for status 1 candidates results in an increased transplant rate and a reduction in waitlist mortality. Sharing did not impact waitlist mortality for non-status 1 candidates.

Authors+Show Affiliations

Transplant Center, University of Texas Health Science Center, San Antonio, TX 78229, USA. washburn@uthscsa.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

16498664

Citation

Washburn, Kenneth, et al. "Regional Sharing for Adult Status 1 Candidates: Reduction in Waitlist Mortality." Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, vol. 12, no. 3, 2006, pp. 470-4.
Washburn K, Harper A, Klintmalm G, et al. Regional sharing for adult status 1 candidates: reduction in waitlist mortality. Liver Transpl. 2006;12(3):470-4.
Washburn, K., Harper, A., Klintmalm, G., Goss, J., & Halff, G. (2006). Regional sharing for adult status 1 candidates: reduction in waitlist mortality. Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, 12(3), 470-4.
Washburn K, et al. Regional Sharing for Adult Status 1 Candidates: Reduction in Waitlist Mortality. Liver Transpl. 2006;12(3):470-4. PubMed PMID: 16498664.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Regional sharing for adult status 1 candidates: reduction in waitlist mortality. AU - Washburn,Kenneth, AU - Harper,Ann, AU - Klintmalm,Goran, AU - Goss,John, AU - Halff,Glenn, PY - 2006/2/25/pubmed PY - 2006/8/5/medline PY - 2006/2/25/entrez SP - 470 EP - 4 JF - Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society JO - Liver Transpl VL - 12 IS - 3 N2 - The intent of regional sharing for status 1 candidates is to promote timely access to donor livers. Presumably this decreases waitlist mortality. Little published data exists that supports this policy. Organ Procurement and Transplantation Network data was used to calculate region 4 and national adult waitlist death and transplant rates 4 yr prior to (period A) and after (period B) implementation of the sharing agreement in July 1999. Death and transplant rates were calculated using a competing risk analysis. Regional sharing resulted in a reduction in adult status 1 waitlist death rate and an increase in transplant rate for region 4 candidates at 7 and 14 days (P > 0.05) without a change in the death rate at 90 days for the non-status 1 candidates. National data showed a significant increase in transplant rate at 7 days and reduction in waitlist death rate at 14 days after listing (P < 0.05). Status 1 waiting time was decreased from 10 to 3 days (P < 0.05). Adult patient survival was not significantly different between the periods. In conclusion, regional sharing for status 1 candidates results in an increased transplant rate and a reduction in waitlist mortality. Sharing did not impact waitlist mortality for non-status 1 candidates. SN - 1527-6465 UR - https://www.unboundmedicine.com/medline/citation/16498664/Regional_sharing_for_adult_status_1_candidates:_reduction_in_waitlist_mortality_ L2 - https://doi.org/10.1002/lt.20768 DB - PRIME DP - Unbound Medicine ER -