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New strategies for management of oral mucositis in cancer patients.
J Support Oncol 2006; 4(2 Suppl 1):9-13JS

Abstract

Oral mucositis can be a significant problem for cancer patients and is frequently seen in the patient population receiving high-dose head and neck radiation therapy (85%-100%), stem cell transplantation (75%-100%), and myelosuppressive chemotherapy for solid tumors (5%-40%). Current guidelines published through the joint efforts of the Multinational Association of Supportive Care in Cancer and the International Society for Oral Oncology recommend strategies for the prevention and treatment of mucositis in the setting of radiation therapy, chemotherapy, and combined chemoradiation therapy. An improved understanding of its pathologic basis has led to the development of targeted agents to combat mucositis. One of these drugs, palifermin, is a keratinocyte growth factor agent approved for patients with hematologic malignancies receiving myelotoxic therapy requiring hematopoietic stem cell support. Another agent is AES-14, an uptake-enhanced L-glutamine suspension that has shown efficacy in phase III trials in reducing the risk of developing oral mucositis in breast cancer patients receiving chemotherapy. As the understanding of the pathobiology of mucositis improves, clinicians should be able to customize future therapies based on each patients risk for developing the condition.

Authors+Show Affiliations

Head & Neck/Oral Oncology Program, Neag Comprehensive Cancer Center, Department of Oral Health and Diagnostic Science, School of Dental Medicine, University of Connecticut Health Center, Farmington 06030-1605, USA. peterson@nso.uchc.edu

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16499139

Citation

Peterson, Douglas E.. "New Strategies for Management of Oral Mucositis in Cancer Patients." The Journal of Supportive Oncology, vol. 4, no. 2 Suppl 1, 2006, pp. 9-13.
Peterson DE. New strategies for management of oral mucositis in cancer patients. J Support Oncol. 2006;4(2 Suppl 1):9-13.
Peterson, D. E. (2006). New strategies for management of oral mucositis in cancer patients. The Journal of Supportive Oncology, 4(2 Suppl 1), pp. 9-13.
Peterson DE. New Strategies for Management of Oral Mucositis in Cancer Patients. J Support Oncol. 2006;4(2 Suppl 1):9-13. PubMed PMID: 16499139.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - New strategies for management of oral mucositis in cancer patients. A1 - Peterson,Douglas E, PY - 2006/2/28/pubmed PY - 2006/4/18/medline PY - 2006/2/28/entrez SP - 9 EP - 13 JF - The journal of supportive oncology JO - J Support Oncol VL - 4 IS - 2 Suppl 1 N2 - Oral mucositis can be a significant problem for cancer patients and is frequently seen in the patient population receiving high-dose head and neck radiation therapy (85%-100%), stem cell transplantation (75%-100%), and myelosuppressive chemotherapy for solid tumors (5%-40%). Current guidelines published through the joint efforts of the Multinational Association of Supportive Care in Cancer and the International Society for Oral Oncology recommend strategies for the prevention and treatment of mucositis in the setting of radiation therapy, chemotherapy, and combined chemoradiation therapy. An improved understanding of its pathologic basis has led to the development of targeted agents to combat mucositis. One of these drugs, palifermin, is a keratinocyte growth factor agent approved for patients with hematologic malignancies receiving myelotoxic therapy requiring hematopoietic stem cell support. Another agent is AES-14, an uptake-enhanced L-glutamine suspension that has shown efficacy in phase III trials in reducing the risk of developing oral mucositis in breast cancer patients receiving chemotherapy. As the understanding of the pathobiology of mucositis improves, clinicians should be able to customize future therapies based on each patients risk for developing the condition. SN - 1544-6794 UR - https://www.unboundmedicine.com/medline/citation/16499139/New_strategies_for_management_of_oral_mucositis_in_cancer_patients_ L2 - http://www.diseaseinfosearch.org/result/5395 DB - PRIME DP - Unbound Medicine ER -