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Chaetoglobosin U, a cytochalasan alkaloid from endophytic Chaetomium globosum IFB-E019.
J Nat Prod. 2006 Feb; 69(2):302-4.JN

Abstract

A new cytotoxic cytochalasan-based alkaloid named chaetoglobosin U (1), along with four known analogues, chaetoglobosins C (2), F (3), and E (5) and penochalasin A (4), has been characterized from the EtOAc extract of a solid culture of Chaetomium globosum IFB-E019, an endophytic fungus residing inside the stem of healthy Imperata cylindrica. The structure of chaetoglobosin U was determined through correlative analyses of its UV, IR, CD, MS, and 1D ((1)H and(13)C NMR and DEPT) and 2D NMR (COSY, NOESY, HMQC, and HMBC) data. Chaetoglobosin U (1) exhibited cytotoxic activity against the human nasopharyngeal epidermoid tumor KB cell line with an IC(50) value of 16.0 microM, comparable to that (14.0 microM) of 5-fluorouracil co-assayed as a positive reference. The known analogues 2-5 were moderately active to the cell line, with IC(50) values of 34.0, 52.0, 48.0, and 40.0 microM, respectively.

Authors+Show Affiliations

Ding G
Institute of Functional Biomolecules, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, People's Republic of China.
Song YC
No affiliation info available
Chen JR
No affiliation info available
Xu C
No affiliation info available
Ge HM
No affiliation info available
Wang XT
No affiliation info available
Tan RX
No affiliation info available

MeSH

Antineoplastic AgentsChaetomiumChinaDrug Screening Assays, AntitumorHumansIndole AlkaloidsKB CellsMolecular Structure

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16499339

Citation

Ding, Gang, et al. "Chaetoglobosin U, a Cytochalasan Alkaloid From Endophytic Chaetomium Globosum IFB-E019." Journal of Natural Products, vol. 69, no. 2, 2006, pp. 302-4.
Ding G, Song YC, Chen JR, et al. Chaetoglobosin U, a cytochalasan alkaloid from endophytic Chaetomium globosum IFB-E019. J Nat Prod. 2006;69(2):302-4.
Ding, G., Song, Y. C., Chen, J. R., Xu, C., Ge, H. M., Wang, X. T., & Tan, R. X. (2006). Chaetoglobosin U, a cytochalasan alkaloid from endophytic Chaetomium globosum IFB-E019. Journal of Natural Products, 69(2), 302-4.
Ding G, et al. Chaetoglobosin U, a Cytochalasan Alkaloid From Endophytic Chaetomium Globosum IFB-E019. J Nat Prod. 2006;69(2):302-4. PubMed PMID: 16499339.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Chaetoglobosin U, a cytochalasan alkaloid from endophytic Chaetomium globosum IFB-E019. AU - Ding,Gang, AU - Song,Yong C, AU - Chen,Jing R, AU - Xu,Chen, AU - Ge,Hui M, AU - Wang,Xiao T, AU - Tan,Ren X, PY - 2006/2/28/pubmed PY - 2006/4/4/medline PY - 2006/2/28/entrez SP - 302 EP - 4 JF - Journal of natural products JO - J Nat Prod VL - 69 IS - 2 N2 - A new cytotoxic cytochalasan-based alkaloid named chaetoglobosin U (1), along with four known analogues, chaetoglobosins C (2), F (3), and E (5) and penochalasin A (4), has been characterized from the EtOAc extract of a solid culture of Chaetomium globosum IFB-E019, an endophytic fungus residing inside the stem of healthy Imperata cylindrica. The structure of chaetoglobosin U was determined through correlative analyses of its UV, IR, CD, MS, and 1D ((1)H and(13)C NMR and DEPT) and 2D NMR (COSY, NOESY, HMQC, and HMBC) data. Chaetoglobosin U (1) exhibited cytotoxic activity against the human nasopharyngeal epidermoid tumor KB cell line with an IC(50) value of 16.0 microM, comparable to that (14.0 microM) of 5-fluorouracil co-assayed as a positive reference. The known analogues 2-5 were moderately active to the cell line, with IC(50) values of 34.0, 52.0, 48.0, and 40.0 microM, respectively. SN - 0163-3864 UR - https://www.unboundmedicine.com/medline/citation/16499339/Chaetoglobosin_U_a_cytochalasan_alkaloid_from_endophytic_Chaetomium_globosum_IFB_E019_ DB - PRIME DP - Unbound Medicine ER -