Tags

Type your tag names separated by a space and hit enter

Fatty acids in serum cholesteryl esters in relation to asthma and lung function in children.

Abstract

BACKGROUND

Dietary fatty acid intake has been proposed to contribute to asthma development with n-6 polyunsaturated fatty acids (PUFA) having a detrimental and n-3 PUFA a protective effect.

OBJECTIVE

The aim of our analysis was to explore the relationship between fatty acid composition of serum cholesteryl esters as marker of dietary intake and prevalence of asthma, impaired lung function and bronchial hyper-responsiveness in children.

METHODS

The study population consisted of 242 girls and 284 boys aged 8-11 years, living in Munich, Germany. Data were collected by parental questionnaire, lung function measurement and skin prick test according to the International Study of Asthma and Allergies in Childhood phase II protocol. Confounder-adjusted odds ratios (OR) with 95% confidence intervals (CI) were calculated for the association between quartiles of fatty acid concentration and health outcomes with the first quartile as reference.

RESULTS

n-3 PUFA: levels of eicosapentaenoic acid were not related to asthma and impaired lung function. Linolenic acid levels were positively associated with current asthma (OR for fourth quartile 3.35, 95% CI 1.29-8.66). Forced expiratory volume in 1 s (FEV(1)) values decreased with increasing levels of linolenic acid (p for trend=0.057). n-6 PUFA: there was a strong positive association between arachidonic acid levels and current asthma (OR(4th quartile) 4.54, 1.77-11.62) and a negative association with FEV(1) (P=0.036). In contrast, linoleic acid was negatively related to current asthma (OR(4th quartile) 0.34, 0.14-0.87) and FEV(1) values increased with increasing levels of linoleic acid (P=0.022). The ratio of measured n-6 to n-3 PUFA as well as levels of palmitic and oleic acid were not consistently related to asthma or lung function.

CONCLUSION

Our data do not support the hypothesis of a protective role of n-3 PUFA. Elevated arachidonic acid levels in children with asthma may be because of a disturbed balance in the metabolism of n-6 PUFA or may be secondary to inflammation in these patients.

Links

  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Department of Epidemiology, University of Ulm, Ulm, Germany.

    , , , , ,

    Source

    MeSH

    Arachidonic Acid
    Asthma
    Bronchial Hyperreactivity
    Case-Control Studies
    Child
    Cholesterol Esters
    Fatty Acids, Omega-3
    Fatty Acids, Omega-6
    Female
    Forced Expiratory Volume
    Humans
    Lung
    Male
    Oleic Acid
    Palmitic Acid
    Vital Capacity

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    16499639

    Citation

    Bolte, G, et al. "Fatty Acids in Serum Cholesteryl Esters in Relation to Asthma and Lung Function in Children." Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology, vol. 36, no. 3, 2006, pp. 293-302.
    Bolte G, Kompauer I, Fobker M, et al. Fatty acids in serum cholesteryl esters in relation to asthma and lung function in children. Clin Exp Allergy. 2006;36(3):293-302.
    Bolte, G., Kompauer, I., Fobker, M., Cullen, P., Keil, U., Mutius, E., & Weiland, S. K. (2006). Fatty acids in serum cholesteryl esters in relation to asthma and lung function in children. Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology, 36(3), pp. 293-302.
    Bolte G, et al. Fatty Acids in Serum Cholesteryl Esters in Relation to Asthma and Lung Function in Children. Clin Exp Allergy. 2006;36(3):293-302. PubMed PMID: 16499639.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Fatty acids in serum cholesteryl esters in relation to asthma and lung function in children. AU - Bolte,G, AU - Kompauer,I, AU - Fobker,M, AU - Cullen,P, AU - Keil,U, AU - Mutius,E, AU - Weiland,S K, PY - 2006/2/28/pubmed PY - 2006/8/22/medline PY - 2006/2/28/entrez SP - 293 EP - 302 JF - Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology JO - Clin. Exp. Allergy VL - 36 IS - 3 N2 - BACKGROUND: Dietary fatty acid intake has been proposed to contribute to asthma development with n-6 polyunsaturated fatty acids (PUFA) having a detrimental and n-3 PUFA a protective effect. OBJECTIVE: The aim of our analysis was to explore the relationship between fatty acid composition of serum cholesteryl esters as marker of dietary intake and prevalence of asthma, impaired lung function and bronchial hyper-responsiveness in children. METHODS: The study population consisted of 242 girls and 284 boys aged 8-11 years, living in Munich, Germany. Data were collected by parental questionnaire, lung function measurement and skin prick test according to the International Study of Asthma and Allergies in Childhood phase II protocol. Confounder-adjusted odds ratios (OR) with 95% confidence intervals (CI) were calculated for the association between quartiles of fatty acid concentration and health outcomes with the first quartile as reference. RESULTS: n-3 PUFA: levels of eicosapentaenoic acid were not related to asthma and impaired lung function. Linolenic acid levels were positively associated with current asthma (OR for fourth quartile 3.35, 95% CI 1.29-8.66). Forced expiratory volume in 1 s (FEV(1)) values decreased with increasing levels of linolenic acid (p for trend=0.057). n-6 PUFA: there was a strong positive association between arachidonic acid levels and current asthma (OR(4th quartile) 4.54, 1.77-11.62) and a negative association with FEV(1) (P=0.036). In contrast, linoleic acid was negatively related to current asthma (OR(4th quartile) 0.34, 0.14-0.87) and FEV(1) values increased with increasing levels of linoleic acid (P=0.022). The ratio of measured n-6 to n-3 PUFA as well as levels of palmitic and oleic acid were not consistently related to asthma or lung function. CONCLUSION: Our data do not support the hypothesis of a protective role of n-3 PUFA. Elevated arachidonic acid levels in children with asthma may be because of a disturbed balance in the metabolism of n-6 PUFA or may be secondary to inflammation in these patients. SN - 0954-7894 UR - https://www.unboundmedicine.com/medline/citation/16499639/Fatty_acids_in_serum_cholesteryl_esters_in_relation_to_asthma_and_lung_function_in_children_ L2 - https://doi.org/10.1111/j.1365-2222.2006.02441.x DB - PRIME DP - Unbound Medicine ER -