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Intrathecal fentanyl as adjunct to hyperbaric bupivacaine in spinal anesthesia for caesarean section.
J Coll Physicians Surg Pak. 2006 Feb; 16(2):87-90.JC

Abstract

OBJECTIVE

To compare the effect of adding fentanyl to intrathecal bupivacaine on the onset, duration and quality of spinal anesthesia and its effect of mother and neonate.

DESIGN

Single blind randomized controlled clinical trial.

PLACE AND DURATION OF STUDY

Department of Anesthesiology, Surgical Intensive Care Unit and Pain Management, Dow University of Health Sciences and Civil Hospital, Karachi, from January 2003 to June 2004.

PATIENTS AND METHODS

Sixty young adult females, ASA physical status I and II, with singleton pregnancy undergoing elective or emergency cesarean section under spinal anesthesia were randomly allocated to receive spinal anesthesia either by using 0.75% hyperbaric bupivacaine 1.5 ml with 0.25 ml normal saline or 0.75% hyperbaric bupivacaine 1.5 ml with 0.25 ml fentanyl (12.5 microg). Blood pressure, heart rate, respiratory rate, oxygen saturation, sensory level, motor block, pain score and side effects were observed every 2 minutes for first 20 minutes, then at-5 minute interval throughout the surgery, thereafter at 30 minutes interval until the patient complained of pain.

RESULTS

Comparing the bupivacaine group, time to achieve highest sensory level was significantly shorter in fentanyl group (*p < 0.05), while the duration of complete analgesia (time from injection to first report of pain) lasted significantly more longer in fentanyl group (184+/-20 minutes) than bupivacaine group (126+/-10 minutes). Duration of effective analgesia was also significantly more prolonged in fentanyl group (p < 0.05). There was no significant difference in the incidence of side effects between the two groups.

CONCLUSION

Addition of fentanyl to intrathecal bupivacaine results in faster onset with improved peri-operative anesthesia without increasing the side effects.

Authors+Show Affiliations

Department of Anesthesiology, Surgical I.C.U and Pain Management, Dow University of Health Sciences and Civil Hospital, Karachi.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

16499796

Citation

Bano, Fauzia, et al. "Intrathecal Fentanyl as Adjunct to Hyperbaric Bupivacaine in Spinal Anesthesia for Caesarean Section." Journal of the College of Physicians and Surgeons--Pakistan : JCPSP, vol. 16, no. 2, 2006, pp. 87-90.
Bano F, Sabbar S, Zafar S, et al. Intrathecal fentanyl as adjunct to hyperbaric bupivacaine in spinal anesthesia for caesarean section. J Coll Physicians Surg Pak. 2006;16(2):87-90.
Bano, F., Sabbar, S., Zafar, S., Rafeeq, N., Iqbal, M. N., Haider, S., Aftab, S., & Sultan, S. T. (2006). Intrathecal fentanyl as adjunct to hyperbaric bupivacaine in spinal anesthesia for caesarean section. Journal of the College of Physicians and Surgeons--Pakistan : JCPSP, 16(2), 87-90.
Bano F, et al. Intrathecal Fentanyl as Adjunct to Hyperbaric Bupivacaine in Spinal Anesthesia for Caesarean Section. J Coll Physicians Surg Pak. 2006;16(2):87-90. PubMed PMID: 16499796.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Intrathecal fentanyl as adjunct to hyperbaric bupivacaine in spinal anesthesia for caesarean section. AU - Bano,Fauzia, AU - Sabbar,Saleem, AU - Zafar,Safia, AU - Rafeeq,Nabeela, AU - Iqbal,Mirza Nasir, AU - Haider,Saeeda, AU - Aftab,Sadqa, AU - Sultan,S Tipu, PY - 2005/06/17/received PY - 2005/11/08/accepted PY - 2006/2/28/pubmed PY - 2006/7/11/medline PY - 2006/2/28/entrez SP - 87 EP - 90 JF - Journal of the College of Physicians and Surgeons--Pakistan : JCPSP JO - J Coll Physicians Surg Pak VL - 16 IS - 2 N2 - OBJECTIVE: To compare the effect of adding fentanyl to intrathecal bupivacaine on the onset, duration and quality of spinal anesthesia and its effect of mother and neonate. DESIGN: Single blind randomized controlled clinical trial. PLACE AND DURATION OF STUDY: Department of Anesthesiology, Surgical Intensive Care Unit and Pain Management, Dow University of Health Sciences and Civil Hospital, Karachi, from January 2003 to June 2004. PATIENTS AND METHODS: Sixty young adult females, ASA physical status I and II, with singleton pregnancy undergoing elective or emergency cesarean section under spinal anesthesia were randomly allocated to receive spinal anesthesia either by using 0.75% hyperbaric bupivacaine 1.5 ml with 0.25 ml normal saline or 0.75% hyperbaric bupivacaine 1.5 ml with 0.25 ml fentanyl (12.5 microg). Blood pressure, heart rate, respiratory rate, oxygen saturation, sensory level, motor block, pain score and side effects were observed every 2 minutes for first 20 minutes, then at-5 minute interval throughout the surgery, thereafter at 30 minutes interval until the patient complained of pain. RESULTS: Comparing the bupivacaine group, time to achieve highest sensory level was significantly shorter in fentanyl group (*p < 0.05), while the duration of complete analgesia (time from injection to first report of pain) lasted significantly more longer in fentanyl group (184+/-20 minutes) than bupivacaine group (126+/-10 minutes). Duration of effective analgesia was also significantly more prolonged in fentanyl group (p < 0.05). There was no significant difference in the incidence of side effects between the two groups. CONCLUSION: Addition of fentanyl to intrathecal bupivacaine results in faster onset with improved peri-operative anesthesia without increasing the side effects. SN - 1022-386X UR - https://www.unboundmedicine.com/medline/citation/16499796/Intrathecal_fentanyl_as_adjunct_to_hyperbaric_bupivacaine_in_spinal_anesthesia_for_caesarean_section_ L2 - https://medlineplus.gov/cesareansection.html DB - PRIME DP - Unbound Medicine ER -