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Glutaraldehyde and glyoxal cross-linked chitosan microspheres for controlled delivery of centchroman.
Carbohydr Res. 2006 May 01; 341(6):744-56.CR

Abstract

Glutaraldehyde and glyoxal cross-linked microspheres were prepared using chitosan with different molecular weights (MWs) and degrees of deacetylation (DDAs) for sustained release of centchroman under physiological conditions. The DDA in chitosan was determined by different methods, and the samples were categorized as chitosan with low (48%), medium (62%), and high (75%) DDA. The size and shape of the microspheres were determined by scanning electron microscopy (SEM), and hydrophobicity was determined by adsorption of Rose Bengal dye on microspheres cross-linked with glutaraldehyde or glyoxal. The effect of MW, DDA, and degree of cross-linking in microspheres was studied on the degree of swelling, as well as by the loading and release of centchroman. The glyoxal cross-linked microspheres were more compact and hydrophobic and showed better sustained release in companion to chitosan microspheres and glutaraldehyde cross-linked microspheres. The linear fractional release of centchroman with the square root of time indicated a Fickian behavior of centchroman, and the microspheres also showed zero-order release kinetics for centchroman.

Authors+Show Affiliations

Department of Chemistry, Polymer Research Laboratory, Indian Institute of Technology, Roorkee 247 667, India. kcgptfcy@iitr.ernet.inNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16499893

Citation

Gupta, K C., and Fawzi Habeeb Jabrail. "Glutaraldehyde and Glyoxal Cross-linked Chitosan Microspheres for Controlled Delivery of Centchroman." Carbohydrate Research, vol. 341, no. 6, 2006, pp. 744-56.
Gupta KC, Jabrail FH. Glutaraldehyde and glyoxal cross-linked chitosan microspheres for controlled delivery of centchroman. Carbohydr Res. 2006;341(6):744-56.
Gupta, K. C., & Jabrail, F. H. (2006). Glutaraldehyde and glyoxal cross-linked chitosan microspheres for controlled delivery of centchroman. Carbohydrate Research, 341(6), 744-56.
Gupta KC, Jabrail FH. Glutaraldehyde and Glyoxal Cross-linked Chitosan Microspheres for Controlled Delivery of Centchroman. Carbohydr Res. 2006 May 1;341(6):744-56. PubMed PMID: 16499893.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Glutaraldehyde and glyoxal cross-linked chitosan microspheres for controlled delivery of centchroman. AU - Gupta,K C, AU - Jabrail,Fawzi Habeeb, Y1 - 2006/02/24/ PY - 2005/10/15/received PY - 2006/01/25/revised PY - 2006/02/07/accepted PY - 2006/2/28/pubmed PY - 2006/8/5/medline PY - 2006/2/28/entrez SP - 744 EP - 56 JF - Carbohydrate research JO - Carbohydr Res VL - 341 IS - 6 N2 - Glutaraldehyde and glyoxal cross-linked microspheres were prepared using chitosan with different molecular weights (MWs) and degrees of deacetylation (DDAs) for sustained release of centchroman under physiological conditions. The DDA in chitosan was determined by different methods, and the samples were categorized as chitosan with low (48%), medium (62%), and high (75%) DDA. The size and shape of the microspheres were determined by scanning electron microscopy (SEM), and hydrophobicity was determined by adsorption of Rose Bengal dye on microspheres cross-linked with glutaraldehyde or glyoxal. The effect of MW, DDA, and degree of cross-linking in microspheres was studied on the degree of swelling, as well as by the loading and release of centchroman. The glyoxal cross-linked microspheres were more compact and hydrophobic and showed better sustained release in companion to chitosan microspheres and glutaraldehyde cross-linked microspheres. The linear fractional release of centchroman with the square root of time indicated a Fickian behavior of centchroman, and the microspheres also showed zero-order release kinetics for centchroman. SN - 0008-6215 UR - https://www.unboundmedicine.com/medline/citation/16499893/Glutaraldehyde_and_glyoxal_cross_linked_chitosan_microspheres_for_controlled_delivery_of_centchroman_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0008-6215(06)00061-9 DB - PRIME DP - Unbound Medicine ER -