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Low levels of docosahexaenoic acid identified in acute coronary syndrome patients with depression.
Psychiatry Res. 2006 Mar 30; 141(3):279-86.PR

Abstract

As deficiencies in n-3 PUFAs have been linked separately to depression and to cardiovascular disease, they could act as a higher order variable contributing to the established link between depression and cardiovascular disease. We therefore examine the relationship between depression and omega-3 polyunsaturated fatty acids (n-3 PUFA), including total n-3 PUFA, docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), in patients with acute coronary syndrome (ACS). Plasma phospholipid levels of n-3 PUFA were measured in 100 patients hospitalized with ACS. Current major depressive episode was assessed by the Composite International Diagnostic Interview (CIDI). Depression severity was assessed by the 18-item Depression in the Medically Ill (DMI-18) measure. Patients clinically diagnosed with current depression had significantly lower mean total n-3 PUFA and DHA levels. Higher DMI-18 depression severity scores were significantly associated with lower DHA levels, with similar but non-significant trends observed for EPA and total n-3 PUFA levels. The finding that low DHA levels were associated with depression variables in ACS patients may explain links demonstrated between cardiovascular health and depression, and may have prophylactic and treatment implications.

Authors+Show Affiliations

School of Psychiatry, University of New South Wales, Prince of Wales Hospital, Randwick, NSW 2031, Australia. g.parker@unsw.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16499974

Citation

Parker, Gordon B., et al. "Low Levels of Docosahexaenoic Acid Identified in Acute Coronary Syndrome Patients With Depression." Psychiatry Research, vol. 141, no. 3, 2006, pp. 279-86.
Parker GB, Heruc GA, Hilton TM, et al. Low levels of docosahexaenoic acid identified in acute coronary syndrome patients with depression. Psychiatry Res. 2006;141(3):279-86.
Parker, G. B., Heruc, G. A., Hilton, T. M., Olley, A., Brotchie, H., Hadzi-Pavlovic, D., Friend, C., Walsh, W. F., & Stocker, R. (2006). Low levels of docosahexaenoic acid identified in acute coronary syndrome patients with depression. Psychiatry Research, 141(3), 279-86.
Parker GB, et al. Low Levels of Docosahexaenoic Acid Identified in Acute Coronary Syndrome Patients With Depression. Psychiatry Res. 2006 Mar 30;141(3):279-86. PubMed PMID: 16499974.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Low levels of docosahexaenoic acid identified in acute coronary syndrome patients with depression. AU - Parker,Gordon B, AU - Heruc,Gabriella A, AU - Hilton,Therese M, AU - Olley,Amanda, AU - Brotchie,Heather, AU - Hadzi-Pavlovic,Dusan, AU - Friend,Cheryl, AU - Walsh,Warren F, AU - Stocker,Roland, Y1 - 2006/02/24/ PY - 2005/06/27/received PY - 2005/07/29/revised PY - 2005/08/05/accepted PY - 2006/2/28/pubmed PY - 2006/10/6/medline PY - 2006/2/28/entrez SP - 279 EP - 86 JF - Psychiatry research JO - Psychiatry Res VL - 141 IS - 3 N2 - As deficiencies in n-3 PUFAs have been linked separately to depression and to cardiovascular disease, they could act as a higher order variable contributing to the established link between depression and cardiovascular disease. We therefore examine the relationship between depression and omega-3 polyunsaturated fatty acids (n-3 PUFA), including total n-3 PUFA, docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), in patients with acute coronary syndrome (ACS). Plasma phospholipid levels of n-3 PUFA were measured in 100 patients hospitalized with ACS. Current major depressive episode was assessed by the Composite International Diagnostic Interview (CIDI). Depression severity was assessed by the 18-item Depression in the Medically Ill (DMI-18) measure. Patients clinically diagnosed with current depression had significantly lower mean total n-3 PUFA and DHA levels. Higher DMI-18 depression severity scores were significantly associated with lower DHA levels, with similar but non-significant trends observed for EPA and total n-3 PUFA levels. The finding that low DHA levels were associated with depression variables in ACS patients may explain links demonstrated between cardiovascular health and depression, and may have prophylactic and treatment implications. SN - 0165-1781 UR - https://www.unboundmedicine.com/medline/citation/16499974/Low_levels_of_docosahexaenoic_acid_identified_in_acute_coronary_syndrome_patients_with_depression_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0165-1781(05)00237-4 DB - PRIME DP - Unbound Medicine ER -