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Relation of C-reactive protein to oxidative stress and to endothelial activation in essential hypertension.
Am J Hypertens. 2006 Mar; 19(3):313-8.AJ

Abstract

BACKGROUND

C-reactive protein (CRP) predicts cardiovascular outcome. Oxidative stress is considered to be involved in endothelial alteration. We hypothesized that in essential hypertension (EH), oxidative stress, as measured by 8-iso-prostaglandin-F(2alpha) (8-iso-PGF(2alpha)), should be associated with increased CRP and endothelial activation, as evaluated by soluble intercellular adhesion molecule-1 (ICAM-1) and vascular adhesion molecule-1 (VCAM-1) plasma levels.

METHODS

In 83 subjects with mild EH and in 50 healthy control subjects we measured, in basal conditions, plasma levels of hs-CRP, 8-iso-PGF(2alpha), ICAM-1 and VCAM-1, and tumor necrosis factor-alpha (TNF-alpha).

RESULTS

Subjects with EH had higher levels of 8-iso-PGF(2alpha) (P < .0001), CRP (P < .001), ICAM-1 and VCAM-1 (P < .001), and TNF-alpha (P < .001) than did control subjects. We divided successively EH according to CRP values (<1, 1-3, >3 mg/L), and we observed increasing and significantly different levels of the endothelial parameters and of TNF-alpha along with increasing CRP. Linear analysis of correlation pointed out significant correlation of CRP with 8-iso-PGF(2alpha) (r = 0.730, P < .001), ICAM-1 and VCAM-1 (r = 0.642 and 0.468, P < .001 respectively), and TNF-alpha (r = 0.609, P < .001). Multiple regression analysis using CRP as a dependent variable confirmed the relationship of CRP with systolic blood pressure (beta 0.216, P = 0.039) and with 8-iso-PGF(2alpha) (beta 0.602, P = .0001).

CONCLUSIONS

Our data demonstrate that in EH, inflammatory molecules such as CRP and TNF-alpha are increased and related to both oxidative stress and endothelial activation.

Authors+Show Affiliations

Divisione di Medicina Interna, Nefrologia ed Ipertensione Dipartimento di Medicina Interna, Malattie Cardiovascolari e Nefrourologiche-Cattedra di Medicina Interna, Università di Palermo, Palermo, Italy. sancott@tin.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16500520

Citation

Cottone, Santina, et al. "Relation of C-reactive Protein to Oxidative Stress and to Endothelial Activation in Essential Hypertension." American Journal of Hypertension, vol. 19, no. 3, 2006, pp. 313-8.
Cottone S, Mulè G, Nardi E, et al. Relation of C-reactive protein to oxidative stress and to endothelial activation in essential hypertension. Am J Hypertens. 2006;19(3):313-8.
Cottone, S., Mulè, G., Nardi, E., Vadalà, A., Guarneri, M., Briolotta, C., Arsena, R., Palermo, A., Riccobene, R., & Cerasola, G. (2006). Relation of C-reactive protein to oxidative stress and to endothelial activation in essential hypertension. American Journal of Hypertension, 19(3), 313-8.
Cottone S, et al. Relation of C-reactive Protein to Oxidative Stress and to Endothelial Activation in Essential Hypertension. Am J Hypertens. 2006;19(3):313-8. PubMed PMID: 16500520.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relation of C-reactive protein to oxidative stress and to endothelial activation in essential hypertension. AU - Cottone,Santina, AU - Mulè,Giuseppe, AU - Nardi,Emilio, AU - Vadalà,Anna, AU - Guarneri,Marco, AU - Briolotta,Chiara, AU - Arsena,Rosalia, AU - Palermo,Alessandro, AU - Riccobene,Raffaella, AU - Cerasola,Giovanni, PY - 2005/04/21/received PY - 2005/08/30/revised PY - 2005/09/17/accepted PY - 2006/2/28/pubmed PY - 2006/5/4/medline PY - 2006/2/28/entrez SP - 313 EP - 8 JF - American journal of hypertension JO - Am J Hypertens VL - 19 IS - 3 N2 - BACKGROUND: C-reactive protein (CRP) predicts cardiovascular outcome. Oxidative stress is considered to be involved in endothelial alteration. We hypothesized that in essential hypertension (EH), oxidative stress, as measured by 8-iso-prostaglandin-F(2alpha) (8-iso-PGF(2alpha)), should be associated with increased CRP and endothelial activation, as evaluated by soluble intercellular adhesion molecule-1 (ICAM-1) and vascular adhesion molecule-1 (VCAM-1) plasma levels. METHODS: In 83 subjects with mild EH and in 50 healthy control subjects we measured, in basal conditions, plasma levels of hs-CRP, 8-iso-PGF(2alpha), ICAM-1 and VCAM-1, and tumor necrosis factor-alpha (TNF-alpha). RESULTS: Subjects with EH had higher levels of 8-iso-PGF(2alpha) (P < .0001), CRP (P < .001), ICAM-1 and VCAM-1 (P < .001), and TNF-alpha (P < .001) than did control subjects. We divided successively EH according to CRP values (<1, 1-3, >3 mg/L), and we observed increasing and significantly different levels of the endothelial parameters and of TNF-alpha along with increasing CRP. Linear analysis of correlation pointed out significant correlation of CRP with 8-iso-PGF(2alpha) (r = 0.730, P < .001), ICAM-1 and VCAM-1 (r = 0.642 and 0.468, P < .001 respectively), and TNF-alpha (r = 0.609, P < .001). Multiple regression analysis using CRP as a dependent variable confirmed the relationship of CRP with systolic blood pressure (beta 0.216, P = 0.039) and with 8-iso-PGF(2alpha) (beta 0.602, P = .0001). CONCLUSIONS: Our data demonstrate that in EH, inflammatory molecules such as CRP and TNF-alpha are increased and related to both oxidative stress and endothelial activation. SN - 0895-7061 UR - https://www.unboundmedicine.com/medline/citation/16500520/Relation_of_C_reactive_protein_to_oxidative_stress_and_to_endothelial_activation_in_essential_hypertension_ L2 - https://academic.oup.com/ajh/article-lookup/doi/10.1016/j.amjhyper.2005.09.005 DB - PRIME DP - Unbound Medicine ER -