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Monthly consistency of macular pigment optical density and serum concentrations of lutein and zeaxanthin.
Curr Eye Res. 2006 Feb; 31(2):199-213.CE

Abstract

PURPOSE

This study was undertaken to assess serial month-to-month consistency of macular pigment (MP) optical density and serum concentrations of lutein (L) and zeaxanthin (Z). Four healthy subjects aged between 23 and 51 years volunteered to participate in this study.

METHODS

MP optical density (measured psychophysically using heterochromatic flicker photometry [HFP]), and serum concentrations of L and Z (quantified using high-performance liquid chromatography [HPLC]), were recorded every month for 24 consecutive months.

RESULTS

Mean MP optical density (+/-SD) was 0.361 (0.086) and 0.369 (0.074) for right and left eyes, respectively. There was no statistically significant seasonal variation in MP optical density for the group (two-way ANOVA: p>0.05). Serum concentrations of L and Z demonstrated a statistically significant subject-season interaction effect (two-way ANOVA: p<0.01). Serial serum concentrations of L and Z were positively correlated within all four subjects (r=0.370 to 0.786), and significantly so for three subjects (p<0.05). There was no obvious relationship, synchronous or lagged, between serum concentrations of L (or Z) and MP optical density (r=-0.036 to 0.368).

CONCLUSIONS

MP optical density was relatively stable for all subjects over the 24-month period. Fluctuations in serum concentrations of L and Z, in the absence of dietary modification or supplementation, are associated with stable MP optical density.

Authors+Show Affiliations

Macular Pigment Research Laboratory, Department of Chemical and Life Sciences, Waterford Institute of Technology, and Department of Ophthalmology, Waterford Regional Hospital, Ireland. jnolan@wit.ieNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16500771

Citation

Nolan, John M., et al. "Monthly Consistency of Macular Pigment Optical Density and Serum Concentrations of Lutein and Zeaxanthin." Current Eye Research, vol. 31, no. 2, 2006, pp. 199-213.
Nolan JM, Stack J, Mellerio J, et al. Monthly consistency of macular pigment optical density and serum concentrations of lutein and zeaxanthin. Curr Eye Res. 2006;31(2):199-213.
Nolan, J. M., Stack, J., Mellerio, J., Godhinio, M., O'Donovan, O., Neelam, K., & Beatty, S. (2006). Monthly consistency of macular pigment optical density and serum concentrations of lutein and zeaxanthin. Current Eye Research, 31(2), 199-213.
Nolan JM, et al. Monthly Consistency of Macular Pigment Optical Density and Serum Concentrations of Lutein and Zeaxanthin. Curr Eye Res. 2006;31(2):199-213. PubMed PMID: 16500771.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Monthly consistency of macular pigment optical density and serum concentrations of lutein and zeaxanthin. AU - Nolan,John M, AU - Stack,Jim, AU - Mellerio,John, AU - Godhinio,Margery, AU - O'Donovan,Orla, AU - Neelam,Kumari, AU - Beatty,Stephen, PY - 2006/2/28/pubmed PY - 2006/4/19/medline PY - 2006/2/28/entrez SP - 199 EP - 213 JF - Current eye research JO - Curr. Eye Res. VL - 31 IS - 2 N2 - PURPOSE: This study was undertaken to assess serial month-to-month consistency of macular pigment (MP) optical density and serum concentrations of lutein (L) and zeaxanthin (Z). Four healthy subjects aged between 23 and 51 years volunteered to participate in this study. METHODS: MP optical density (measured psychophysically using heterochromatic flicker photometry [HFP]), and serum concentrations of L and Z (quantified using high-performance liquid chromatography [HPLC]), were recorded every month for 24 consecutive months. RESULTS: Mean MP optical density (+/-SD) was 0.361 (0.086) and 0.369 (0.074) for right and left eyes, respectively. There was no statistically significant seasonal variation in MP optical density for the group (two-way ANOVA: p>0.05). Serum concentrations of L and Z demonstrated a statistically significant subject-season interaction effect (two-way ANOVA: p<0.01). Serial serum concentrations of L and Z were positively correlated within all four subjects (r=0.370 to 0.786), and significantly so for three subjects (p<0.05). There was no obvious relationship, synchronous or lagged, between serum concentrations of L (or Z) and MP optical density (r=-0.036 to 0.368). CONCLUSIONS: MP optical density was relatively stable for all subjects over the 24-month period. Fluctuations in serum concentrations of L and Z, in the absence of dietary modification or supplementation, are associated with stable MP optical density. SN - 0271-3683 UR - https://www.unboundmedicine.com/medline/citation/16500771/Monthly_consistency_of_macular_pigment_optical_density_and_serum_concentrations_of_lutein_and_zeaxanthin_ L2 - http://www.tandfonline.com/doi/full/10.1080/02713680500514677 DB - PRIME DP - Unbound Medicine ER -