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Short-term electroacupuncture at Zusanli resets the arterial baroreflex neural arc toward lower sympathetic nerve activity.
. 2006 Jul; 291(1):H318-26.

Abstract

Although electroacupuncture reduces sympathetic nerve activity (SNA) and arterial pressure (AP), the effects of electroacupuncture on the arterial baroreflex remain to be systematically analyzed. We investigated the effects of electroacupuncture of Zusanli on the arterial baroreflex using an equilibrium diagram comprised of neural and peripheral arcs. In anesthetized, vagotomized, and aortic-denervated rabbits, we isolated carotid sinuses and changed intra-carotid sinus pressure (CSP) from 40 to 160 mmHg in increments of 20 mmHg/min while recording cardiac SNA and AP. Electroacupuncture of Zusanli was applied with a pulse duration of 5 ms and a frequency of 1 Hz. An electric current 10 times the minimal threshold current required for visible muscle twitches was used and was determined to be 4.8 +/- 0.3 mA. Electroacupuncture for 8 min decreased SNA and AP (n = 6). It shifted the neural arc (i.e., CSP-SNA relationship) to lower SNA but did not affect the peripheral arc (i.e., SNA-AP relationship) (n = 8). SNA and AP at the closed-loop operating point, determined by the intersection of the neural and peripheral arcs, decreased from 100 +/- 4 to 80 +/- 9 arbitrary units and from 108 +/- 9 to 99 +/- 8 mmHg (each P < 0.005), respectively. Peroneal denervation eliminated the shift of neural arc by electroacupuncture (n = 6). Decreasing the pulse duration to <2.5 ms eliminated the effects of SNA and AP reduction. In conclusion, short-term electroacupuncture resets the neural arc to lower SNA, which moves the operating point toward lower AP and SNA under baroreflex closed-loop conditions.

Authors+Show Affiliations

Department of Cardiovascular Dynamics, Advanced Medical Engineering Center, National Cardiovascular Center Research Institute, Suita, Osaka 565-8565, Japan. dmichi@ri.ncvc.go.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16501021

Citation

Michikami, Daisaku, et al. "Short-term Electroacupuncture at Zusanli Resets the Arterial Baroreflex Neural Arc Toward Lower Sympathetic Nerve Activity." American Journal of Physiology. Heart and Circulatory Physiology, vol. 291, no. 1, 2006, pp. H318-26.
Michikami D, Kamiya A, Kawada T, et al. Short-term electroacupuncture at Zusanli resets the arterial baroreflex neural arc toward lower sympathetic nerve activity. Am J Physiol Heart Circ Physiol. 2006;291(1):H318-26.
Michikami, D., Kamiya, A., Kawada, T., Inagaki, M., Shishido, T., Yamamoto, K., Ariumi, H., Iwase, S., Sugenoya, J., Sunagawa, K., & Sugimachi, M. (2006). Short-term electroacupuncture at Zusanli resets the arterial baroreflex neural arc toward lower sympathetic nerve activity. American Journal of Physiology. Heart and Circulatory Physiology, 291(1), H318-26.
Michikami D, et al. Short-term Electroacupuncture at Zusanli Resets the Arterial Baroreflex Neural Arc Toward Lower Sympathetic Nerve Activity. Am J Physiol Heart Circ Physiol. 2006;291(1):H318-26. PubMed PMID: 16501021.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Short-term electroacupuncture at Zusanli resets the arterial baroreflex neural arc toward lower sympathetic nerve activity. AU - Michikami,Daisaku, AU - Kamiya,Atsunori, AU - Kawada,Toru, AU - Inagaki,Masashi, AU - Shishido,Toshiaki, AU - Yamamoto,Kenta, AU - Ariumi,Hideto, AU - Iwase,Satoshi, AU - Sugenoya,Junichi, AU - Sunagawa,Kenji, AU - Sugimachi,Masaru, Y1 - 2006/02/24/ PY - 2006/2/28/pubmed PY - 2006/8/2/medline PY - 2006/2/28/entrez SP - H318 EP - 26 JF - American journal of physiology. Heart and circulatory physiology JO - Am. J. Physiol. Heart Circ. Physiol. VL - 291 IS - 1 N2 - Although electroacupuncture reduces sympathetic nerve activity (SNA) and arterial pressure (AP), the effects of electroacupuncture on the arterial baroreflex remain to be systematically analyzed. We investigated the effects of electroacupuncture of Zusanli on the arterial baroreflex using an equilibrium diagram comprised of neural and peripheral arcs. In anesthetized, vagotomized, and aortic-denervated rabbits, we isolated carotid sinuses and changed intra-carotid sinus pressure (CSP) from 40 to 160 mmHg in increments of 20 mmHg/min while recording cardiac SNA and AP. Electroacupuncture of Zusanli was applied with a pulse duration of 5 ms and a frequency of 1 Hz. An electric current 10 times the minimal threshold current required for visible muscle twitches was used and was determined to be 4.8 +/- 0.3 mA. Electroacupuncture for 8 min decreased SNA and AP (n = 6). It shifted the neural arc (i.e., CSP-SNA relationship) to lower SNA but did not affect the peripheral arc (i.e., SNA-AP relationship) (n = 8). SNA and AP at the closed-loop operating point, determined by the intersection of the neural and peripheral arcs, decreased from 100 +/- 4 to 80 +/- 9 arbitrary units and from 108 +/- 9 to 99 +/- 8 mmHg (each P < 0.005), respectively. Peroneal denervation eliminated the shift of neural arc by electroacupuncture (n = 6). Decreasing the pulse duration to <2.5 ms eliminated the effects of SNA and AP reduction. In conclusion, short-term electroacupuncture resets the neural arc to lower SNA, which moves the operating point toward lower AP and SNA under baroreflex closed-loop conditions. SN - 0363-6135 UR - https://www.unboundmedicine.com/medline/citation/16501021/Short_term_electroacupuncture_at_Zusanli_resets_the_arterial_baroreflex_neural_arc_toward_lower_sympathetic_nerve_activity_ L2 - https://journals.physiology.org/doi/10.1152/ajpheart.00975.2005?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -